Development Level

Tbio 442 | 11,445
Tchem 81 | 1,598
Tdark 43 | 6,588
Tclin 24 | 613

Collection

Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 73 | 979
embryonic lethality prior to o... 28 | 239
embryonic lethality prior to t... 24 | 278
preweaning lethality, incomple... 18 | 499
abnormal embryo size 16 | 220
male infertility 14 | 123
embryonic growth retardation 10 | 106
decreased body weight 9 | 161
decreased circulating choleste... 9 | 93
increased mean corpuscular vol... 9 | 92
cataract 8 | 92
abnormal bone structure 7 | 187
abnormal heart morphology 7 | 162
abnormal lens morphology 7 | 81
female infertility 7 | 60
decreased bone mineral content 6 | 151
decreased lean body mass 6 | 135
decreased total body fat amoun... 6 | 207
abnormal behavior 5 | 298
edema 5 | 59
increased circulating HDL chol... 5 | 80
increased fasted circulating g... 5 | 76
increased mean corpuscular hem... 5 | 96
prolonged QT interval 5 | 38
prolonged ST segment 5 | 36
small testis 5 | 58
abnormal embryo turning 4 | 31
abnormal seminal vesicle morph... 4 | 114
abnormal tail morphology 4 | 25
decreased body length 4 | 101
decreased bone mineral density 4 | 126
decreased circulating LDL chol... 4 | 38
decreased circulating glucose ... 4 | 126
decreased circulating serum al... 4 | 82
decreased circulating total pr... 4 | 49
decreased vertical activity 4 | 208
enlarged heart 4 | 210
enlarged lymph nodes 4 | 37
hypoactivity 4 | 132
prenatal lethality prior to he... 4 | 87
abnormal behavioral response t... 3 | 66
abnormal head morphology 3 | 10
abnormal placenta size 3 | 20
abnormal spleen morphology 3 | 55
cardiovascular system phenotyp... 3 | 36
decreased caudal vertebrae num... 3 | 53
decreased circulating alanine ... 3 | 47
decreased circulating calcium ... 3 | 36
decreased circulating triglyce... 3 | 79
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 31
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased leukocyte cell numbe... 3 | 47
increased mean platelet volume 3 | 45
increased neutrophil cell numb... 3 | 46
microphthalmia 3 | 26
short tibia 3 | 97
abnormal blood vessel morpholo... 2 | 5
abnormal coat-hair pigmentatio... 2 | 64
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal eye morphology 2 | 68
abnormal joint morphology 2 | 23
abnormal kidney morphology 2 | 65
abnormal locomotor behavior 2 | 24
abnormal lung morphology 2 | 26
abnormal neural tube closure 2 | 46
abnormal placenta morphology 2 | 5
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal skin coloration 2 | 25
abnormal skin morphology 2 | 50
abnormal testis morphology 2 | 43
absent pinna reflex 2 | 23
anophthalmia 2 | 33
corneal opacity 2 | 32
decreased circulating HDL chol... 2 | 68
decreased circulating fructosa... 2 | 30
decreased circulating iron lev... 2 | 32
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased red blood cell distr... 2 | 41
increased bone mineral content 2 | 108
increased circulating chloride... 2 | 41
increased circulating fructosa... 2 | 13
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased monocyte cell number 2 | 63
increased red blood cell distr... 2 | 34
pallor 2 | 34
small superior vagus ganglion 2 | 74
syndactyly 2 | 23
thrombocytosis 2 | 27

Disease

ovarian cancer 382 | 8,520
Carcinoma 365 | 11,493
osteosarcoma 293 | 7,950
medulloblastoma, large-cell 273 | 6,241
lung cancer 271 | 4,740
psoriasis 270 | 6,694
group 3 medulloblastoma 261 | 4,104
glioblastoma 252 | 5,792
atypical teratoid / rhabdoid tumor 231 | 5,112
Breast cancer 214 | 3,578
primitive neuroectodermal tumor 194 | 3,035
malignant mesothelioma 187 | 3,232
non-small cell lung cancer 179 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 178 | 3,291
Cancer 175 | 2,499
ependymoma 162 | 4,679
adult high grade glioma 161 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 157 | 2,989
invasive ductal carcinoma 137 | 2,951
lung adenocarcinoma 136 | 2,716
adrenocortical carcinoma 131 | 1,428
colon cancer 111 | 1,478
Kidney cancer 109 | 2,613
oligodendroglioma 108 | 2,850
ductal carcinoma in situ 105 | 1,745
Multiple myeloma 97 | 1,332
nasopharyngeal carcinoma 96 | 1,058
breast carcinoma 88 | 1,638
pancreatic cancer 82 | 2,398
astrocytic glioma 77 | 2,597
Astrocytoma, Pilocytic 72 | 3,081
Waldenstrons macroglobulinemia 72 | 765
intraductal papillary-mucinous adenoma (IPMA) 71 | 2,955
Atopic dermatitis 68 | 952
Pick disease 68 | 1,894
Endometriosis 67 | 540
subependymal giant cell astrocytoma 65 | 2,287
Intellectual disability 62 | 1,016
dermatomyositis 56 | 966
astrocytoma 54 | 1,146
Autosomal recessive predisposition 53 | 1,442
tuberculosis 52 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,962
Short stature 50 | 531
diabetes mellitus 49 | 1,728
Small head 48 | 374
ulcerative colitis 47 | 1,819
Cognitive delay 46 | 608
Global developmental delay 46 | 608
Mental and motor retardation 46 | 608
Dull intelligence 45 | 645
Low intelligence 45 | 645
Mental Retardation 45 | 645
Mental deficiency 45 | 645
Poor school performance 45 | 645
pediatric high grade glioma 44 | 1,064
Rheumatoid arthritis 43 | 1,191
pituitary cancer 43 | 1,972
Breast Neoplasms 42 | 445
Mammary Neoplasms 42 | 425
acute quadriplegic myopathy 42 | 1,158
interstitial cystitis 41 | 2,312
non primary Sjogren syndrome sicca 38 | 891
Microcephaly 37 | 166
group 4 medulloblastoma 37 | 1,855
lung carcinoma 36 | 2,843
primary Sjogren syndrome 36 | 735
Schizophrenia 34 | 1,160
juvenile dermatomyositis 33 | 1,187
Fetal Growth Retardation 31 | 189
Hypoplastic mandible condyle 31 | 275
Infant, Small for Gestational Age 31 | 176
Intrauterine retardation 31 | 176
Mandibular hypoplasia 31 | 275
Micrognathism 31 | 275
acute myeloid leukemia 30 | 783
Epilepsy 28 | 792
cystic fibrosis 28 | 1,696
Prostatic Neoplasms 27 | 495
Seizures 27 | 596
cutaneous lupus erythematosus 27 | 1,057
esophageal adenocarcinoma 27 | 737
active Crohn's disease 25 | 922
posterior fossa group A ependymoma 25 | 468
progressive supranuclear palsy 24 | 676
Seckel syndrome 23 | 34
Stomach Neoplasms 23 | 300
Colorectal Neoplasms 22 | 243
gastric carcinoma 22 | 807
medulloblastoma 22 | 720
pancreatic carcinoma 22 | 562
spina bifida 22 | 1,074
Glaucoma 21 | 239
HIV Infections 21 | 102
Liver cancer 21 | 604
Lung Neoplasms 21 | 232
Melanoma 21 | 711
tuberculosis and treatment for 6 months 21 | 409
Amyotrophic lateral sclerosis 20 | 451
Anemia 20 | 365

Tissue

Endocrine System 585 | 18,159
Female tissues 580 | 17,400
Blood and immune system 579 | 16,909
Digestive Tract 578 | 17,369
Skin and soft tissues 578 | 17,230
Male tissues 576 | 17,142
Nervous System 576 | 16,725
Urinary Tract 576 | 16,678
Liver and Pancreas 575 | 16,750
Respiratory system 575 | 16,393
Cardiovascular System 563 | 15,192

Target Family

Non-IDG 378 | 12,091
Enzyme 135 | 4,145
Kinase 49 | 634
Transcription Factor 16 | 1,400
Epigenetic 10 | 242
TF/Epigenetic 2 | 38

Reactome Pathway

Cell Cycle 590 | 590
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
Nesprin-2 SYNE2 Tbio Non-IDG -2.62747 380.6 39
Centrosomal protein of 57 kDa CEP57 Tbio Non-IDG -0.98216 11.8 177
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
Condensin-2 complex subunit G2 NCAPG2 Tbio Non-IDG -0.75957 5.48 110
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
HAUS augmin-like complex subunit 2 HAUS2 Tbio Non-IDG 0.71 0.12 44
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283