Development Level

Tbio 15 | 11,445
Tchem 10 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
small superior vagus ganglion 2 | 74
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
decreased bone mineral content 1 | 151
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged uterus 1 | 11
increased eosinophil cell numb... 1 | 11
increased neutrophil cell numb... 1 | 46
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 16 | 11,493
ovarian cancer 16 | 8,520
psoriasis 16 | 6,694
Cancer 15 | 2,499
glioblastoma 13 | 5,792
lung cancer 12 | 4,740
lung carcinoma 11 | 2,843
Astrocytoma, Pilocytic 10 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
osteosarcoma 10 | 7,950
malignant mesothelioma 9 | 3,232
atypical teratoid / rhabdoid tumor 8 | 5,112
ependymoma 8 | 4,679
medulloblastoma, large-cell 8 | 6,241
ulcerative colitis 8 | 1,819
Breast cancer 7 | 3,578
cutaneous lupus erythematosus 7 | 1,057
diabetes mellitus 7 | 1,728
group 4 medulloblastoma 7 | 1,855
pituitary cancer 7 | 1,972
subependymal giant cell astrocytoma 7 | 2,287
Hypersensitivity reaction type II disease 6 | 253
adult high grade glioma 6 | 3,801
invasive ductal carcinoma 6 | 2,951
non-small cell lung cancer 6 | 2,890
pancreatic cancer 6 | 2,398
tuberculosis 6 | 2,010
Arthritis 5 | 290
Colorectal Neoplasms 5 | 243
Kidney cancer 5 | 2,613
Lung Neoplasms 5 | 232
Melanoma 5 | 711
Multiple Sclerosis 5 | 540
Neoplasm Metastasis 5 | 168
Prostatic Neoplasms 5 | 495
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
adrenocortical carcinoma 5 | 1,428
cystic fibrosis 5 | 1,696
gastric carcinoma 5 | 807
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
Autoimmune lymphoproliferative syndrome 4 | 11
Brain Injuries 4 | 65
Duchenne muscular dystrophy 4 | 601
Liver disease 4 | 237
Renal Cell Carcinoma 4 | 214
Reperfusion Injury 4 | 86
Vasculitis 4 | 80
aldosterone-producing adenoma 4 | 665
colon cancer 4 | 1,478
dermatomyositis 4 | 966
hepatocellular carcinoma 4 | 547
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
non-small cell lung carcinoma 4 | 317
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Adenocarcinoma 3 | 122
Asthma 3 | 385
Atherosclerosis 3 | 291
Autosomal recessive predisposition 3 | 1,442
Bipolar Disorder 3 | 666
Carcinoma, Hepatocellular 3 | 228
Carcinoma, Non-Small-Cell Lung 3 | 107
Cerebrovascular disease 3 | 238
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Edema 3 | 81
Eosinophilia 3 | 28
Esophageal Neoplasms 3 | 69
Fatigue 3 | 182
Gaucher disease type 3 3 | 67
Hepatomegaly 3 | 285
Human immunodeficiency virus infectious disease 3 | 138
Inflammatory bowel disease 3 | 151
Leukemia, Myelocytic, Acute 3 | 120
Leukemia, Myeloid, Acute 3 | 105
Liver carcinoma 3 | 240
Lung disease 3 | 142
Myocardial Reperfusion Injury 3 | 37
Pancreatic Neoplasm 3 | 85
Pancreatic Neoplasms 3 | 85
Peripheral Nervous System Diseases 3 | 52
Peripheral Neuropathy 3 | 134
Retinal Detachment 3 | 51
Splenomegaly 3 | 190
Toxic encephalopathy 3 | 141
Vascular disease 3 | 319
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
pediatric high grade glioma 3 | 1,064
primary pancreatic ductal adenocarcinoma 3 | 1,109
primitive neuroectodermal tumor 3 | 3,035
Breast Neoplasms 2 | 445
Mammary Neoplasms 2 | 425

Tissue

Blood and immune system 25 | 16,909
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678
Liver and Pancreas 24 | 16,750
Cardiovascular System 23 | 15,192

Target Family

Non-IDG 18 | 12,091
Kinase 4 | 634
Enzyme 3 | 4,145

Reactome Pathway

Caspase activation via extrins... 25 | 25
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Melanoma-associated antigen D1 MAGED1 Tbio Non-IDG -1.55131 46.3 245
TIR domain-containing adapter molecule 2 TICAM2 Tbio Non-IDG -1.18212 14.6 258
Death-associated protein kinase 2 DAPK2 Tchem Kinase -1.39206 28.7 440
Lymphocyte antigen 96 LY96 Tchem Non-IDG -2.77678 541.2 369
Death-associated protein kinase 3 DAPK3 Tchem Kinase -1.64668 50.7 291
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Death-associated protein kinase 1 DAPK1 Tchem Kinase -2.34153 226.1 276
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.33991 211.8 375
Caspase-3 CASP3 Tchem Enzyme -4.32112 18132.3 1689