Development Level

Tbio 44 | 10,625
Tclin 3 | 602
Tdark 3 | 7,003
Tchem 1 | 1,890

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 8 | 633
embryonic lethality prior to t... 4 | 187
abnormal embryo size 3 | 112
abnormal embryo turning 2 | 15
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
embryonic lethality prior to o... 2 | 148
increased or absent threshold ... 2 | 128
increased prepulse inhibition 2 | 21
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal embryo development 1 | 2
abnormal gait 1 | 51
abnormal pericardium morpholog... 1 | 11
abnormal retina morphology 1 | 100
cardiovascular system phenotyp... 1 | 35
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating insulin ... 1 | 75
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased respiratory quotient 1 | 12
enlarged liver 1 | 3
impaired glucose tolerance 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased fasted circulating g... 1 | 68
increased heart rate variabili... 1 | 4
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
short tibia 1 | 82
thrombocytopenia 1 | 46

Disease

ovarian cancer 35 | 8,484
medulloblastoma, large-cell 21 | 6,234
osteosarcoma 19 | 7,933
psoriasis 18 | 6,685
glioblastoma 17 | 5,572
Obesity 16 | 616
Ciliopathy 14 | 57
Polydactyly 14 | 93
posterior fossa group B ependymoma 14 | 1,530
Bardet-Biedl Syndrome 13 | 40
Retinitis pigmentosa 13 | 153
Intellectual disability 12 | 573
astrocytic glioma 12 | 2,241
atypical teratoid / rhabdoid tumor 12 | 4,369
Cone dystrophy 11 | 57
Pick disease 11 | 1,893
oligodendroglioma 11 | 2,849
Breast cancer 10 | 3,094
Fundus dystrophy 10 | 77
acute quadriplegic myopathy 9 | 1,157
lung cancer 9 | 4,466
Carcinoma 8 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
invasive ductal carcinoma 8 | 2,950
medulloblastoma 8 | 1,524
pilocytic astrocytoma 8 | 3,086
Multiple myeloma 7 | 1,327
ependymoma 7 | 2,514
pediatric high grade glioma 7 | 2,712
breast carcinoma 6 | 1,614
dermatomyositis 6 | 933
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
non-small cell lung cancer 6 | 2,798
progressive supranuclear palsy 6 | 674
Joubert syndrome 5 | 61
Nephronophthisis 5 | 74
Polycystic kidney disease 5 | 54
Waldenstrons macroglobulinemia 5 | 765
adult high grade glioma 5 | 2,148
diabetes mellitus 5 | 1,663
group 4 medulloblastoma 5 | 1,875
juvenile dermatomyositis 5 | 1,189
malignant mesothelioma 5 | 3,162
non primary Sjogren syndrome sicca 5 | 840
pancreatic cancer 5 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
primitive neuroectodermal tumor 5 | 3,031
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis and treatment for 6 months 5 | 686
astrocytoma 4 | 1,493
atypical teratoid/rhabdoid tumor 4 | 1,095
gastric cancer 4 | 430
lung carcinoma 4 | 2,844
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis 4 | 1,557
Choroidal sclerosis 3 | 4
Hypogonadism 3 | 70
Kidney disease 3 | 396
Rheumatoid Arthritis 3 | 1,160
Situs Inversus 3 | 48
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
chronic rhinosinusitis 3 | 512
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 2,254
lung adenocarcinoma 3 | 2,713
pituitary cancer 3 | 1,972
Alzheimer's disease 2 | 644
Asphyxiating thoracic dystrophy 2 | 32
Blindness 2 | 84
Cancer 2 | 2,346
Cystic kidney disease 2 | 25
Duchenne muscular dystrophy 2 | 602
Ellis-Van Creveld syndrome 2 | 18
HIV Infections 2 | 100
Night Blindness 2 | 39
Peripheral Neuropathy 2 | 303
Polycystic Kidney, Autosomal Dominant 2 | 6
Polycystic liver disease 2 | 10
Retinal Degeneration 2 | 49
Senior-Loken syndrome 2 | 21
active Crohn's disease 2 | 918
colon cancer 2 | 1,475
cone-rod dystrophy 2 | 56
gastric carcinoma 2 | 832
hepatocellular carcinoma 2 | 532
interstitial cystitis 2 | 2,299
nasopharyngeal carcinoma 2 | 1,056
pancreatic carcinoma 2 | 567
posterior fossa group A ependymoma 2 | 1,511
primary Sjogren syndrome 2 | 789
primary pancreatic ductal adenocarcinoma 2 | 1,271
renal-hepatic-pancreatic dysplasia 2 | 8
sarcoidosis 2 | 358
spina bifida 2 | 1,064
ulcerative colitis 2 | 2,087
Ameloblastoma 1 | 25
Cervix carcinoma 1 | 6
Mucopolysaccharidosis VI 1 | 6
Skin Neoplasms 1 | 49

Tissue

Blood and immune system 51 | 17,995
Nervous System 51 | 18,561
Cardiovascular System 50 | 17,958
Digestive Tract 50 | 18,473
Endocrine System 50 | 18,512
Female tissues 50 | 18,647
Liver and Pancreas 50 | 18,136
Urinary Tract 50 | 18,444
Male tissues 49 | 17,969
Respiratory system 49 | 17,484
Skin and soft tissues 49 | 18,115

Target Family

Non-IDG 35 | 11,971
Enzyme 8 | 4,146
GPCR 4 | 406
Ion Channel 4 | 341

Reactome Pathway

Cargo trafficking to the peric... 51 | 51
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exocyst complex component 7 EXOC7 Tbio Non-IDG -1.72231 55.8 158
Bardet-Biedl syndrome 7 protein BBS7 Tbio Non-IDG -1.02867 11.1 125
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Rab11 family-interacting protein 3 RAB11FIP3 Tbio Non-IDG -0.81358 5.58 60
T-complex protein 1 subunit delta CCT4 Tbio Non-IDG -1.76354 56.6 151
T-complex protein 1 subunit theta CCT8 Tbio Non-IDG -1.45966 29.4 180
T-complex protein 1 subunit epsilon CCT5 Tbio Non-IDG -1.39059 24.5 183
Exocyst complex component 8 EXOC8 Tbio Non-IDG -1.17455 14.6 65
Bardet-Biedl syndrome 12 protein BBS12 Tbio Non-IDG -0.93991 8.12 37
Cystin-1 CYS1 Tdark Non-IDG -2.37852 217.0 4