Development Level

Tbio 42 | 11,445
Tchem 3 | 1,598
Tclin 3 | 613
Tdark 2 | 6,588

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal embryo size 5 | 220
preweaning lethality, incomple... 4 | 499
abnormal embryo turning 3 | 31
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
embryonic growth retardation 2 | 106
increased circulating alkaline... 2 | 122
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal embryo development 1 | 7
abnormal eye morphology 1 | 68
abnormal forebrain morphology 1 | 10
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain morphology 1 | 10
abnormal limb morphology 1 | 13
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal skin appearance 1 | 3
absent startle reflex 1 | 24
anophthalmia 1 | 33
decreased circulating alkaline... 1 | 46
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
edema 1 | 59
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
short tibia 1 | 97
thrombocytopenia 1 | 56

Disease

Carcinoma 39 | 11,493
ovarian cancer 34 | 8,520
medulloblastoma, large-cell 21 | 6,241
Obesity 19 | 678
ependymoma 19 | 4,679
osteosarcoma 18 | 7,950
Intellectual disability 17 | 1,016
psoriasis 17 | 6,694
Retinitis Pigmentosa 16 | 226
glioblastoma 16 | 5,792
atypical teratoid / rhabdoid tumor 15 | 5,112
Bardet-Biedl syndrome 14 | 51
Ciliopathy 14 | 71
Bardet-Biedl syndrome 1 13 | 22
Autosomal recessive predisposition 12 | 1,442
Polydactyly 12 | 107
astrocytic glioma 12 | 2,597
Cone dystrophy 11 | 71
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Pick disease 11 | 1,894
Poor school performance 11 | 645
oligodendroglioma 11 | 2,850
Breast cancer 10 | 3,578
Congenital hypoplasia of penis 10 | 176
Electroretinogram abnormal 10 | 95
Hypogonadism 10 | 173
Kidney cancer 10 | 2,613
Nystagmus 10 | 317
adult high grade glioma 10 | 3,801
Fundus dystrophy 9 | 83
lung cancer 9 | 4,740
Hypertensive disease 8 | 292
Increase in blood pressure 8 | 119
Retinal Degeneration 8 | 106
Short stature 8 | 531
Ulnar polydactyly of fingers 8 | 47
acute quadriplegic myopathy 8 | 1,158
diabetes mellitus 8 | 1,728
invasive ductal carcinoma 8 | 2,951
Astrocytoma, Pilocytic 7 | 3,081
Cognitive delay 7 | 608
Congenital hypoplasia of ovary 7 | 30
Global developmental delay 7 | 608
Hypoplastic ovary 7 | 30
Mental and motor retardation 7 | 608
Multicystic Dysplastic Kidney 7 | 52
Multiple myeloma 7 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
medulloblastoma 6 | 720
non-small cell lung cancer 6 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
progressive supranuclear palsy 6 | 676
tuberculosis 6 | 2,010
Abnormality of retinal pigmentation 5 | 111
Autosomal recessive polycystic kidney disease 5 | 41
Cataract 5 | 297
Glaucoma 5 | 239
Retinal pigment epithelial abnormality 5 | 111
Small genitalia 5 | 13
Syndactyly 5 | 88
Waldenstrons macroglobulinemia 5 | 765
breast carcinoma 5 | 1,638
dermatomyositis 5 | 966
group 3 medulloblastoma 5 | 4,104
group 4 medulloblastoma 5 | 1,855
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
Anteverted nostril 4 | 191
Blind Vision 4 | 111
Blindness, Legal 4 | 110
Broad flat nasal bridge 4 | 236
Conductive hearing loss 4 | 123
Congenital anomaly of testis 4 | 52
Difficulties with night vision 4 | 87
Hyperinsulinism 4 | 133
Joubert syndrome 4 | 66
Keratoconus 4 | 113
Lens Opacities 4 | 231
Nasal bridge wide 4 | 236
Nephronophthisis 4 | 80
Night Blindness 4 | 101
Ophthalmoplegia 4 | 106
Optic Atrophy 4 | 242
Photophobia 4 | 121
Polycystic Kidney - body part 4 | 18
Polycystic Kidney Diseases 4 | 20
Polydactyly of toes 4 | 12
Sensorineural Hearing Loss (disorder) 4 | 284
astrocytoma 4 | 1,146
gastric cancer 4 | 459
juvenile dermatomyositis 4 | 1,187
lung carcinoma 4 | 2,843
posterior fossa group B ependymoma 4 | 416

Tissue

Endocrine System 49 | 18,159
Nervous System 49 | 16,725
Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Male tissues 48 | 17,142
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Respiratory system 47 | 16,393
Cardiovascular System 45 | 15,192

Target Family

Non-IDG 35 | 12,091
Enzyme 7 | 4,145
GPCR 4 | 408
Ion Channel 4 | 344

Reactome Pathway

Cargo trafficking to the peric... 50 | 50
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rab-3A-interacting protein RAB3IP Tbio Non-IDG -1.03500 11.6 89
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ASAP1 Tbio Non-IDG -1.76454 62.6 183
T-complex protein 1 subunit alpha TCP1 Tbio Non-IDG -2.26984 173.7 468
Polycystin-2 PKD2 Tchem Ion Channel -2.63806 461.3 231
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Bardet-Biedl syndrome 2 protein BBS2 Tbio Non-IDG -2.84516 693.9 69
BBSome-interacting protein 1 BBIP1 Tdark Non-IDG -0.24402 2.13 30
Somatostatin receptor type 3 SSTR3 Tclin GPCR -1.89900 68.6 106
Exocyst complex component 7 EXOC7 Tbio Non-IDG -1.80594 64.5 160