Development Level

Tbio 77 | 11,651
Tclin 9 | 612
Tchem 8 | 1,388
Tdark 3 | 6,593

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
decreased total body fat amoun... 4 | 207
preweaning lethality, complete... 4 | 979
decreased vertical activity 3 | 208
increased circulating HDL chol... 3 | 80
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal heart shape 2 | 5
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
decreased bone mineral density 2 | 126
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
enlarged heart 2 | 210
hydrometra 2 | 53
increased circulating choleste... 2 | 66
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal eye size 1 | 7
abnormal liver size 1 | 5
abnormal nail morphology 1 | 8
abnormal pericardium morpholog... 1 | 26
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal urinary bladder morph... 1 | 11
absent pinna reflex 1 | 23
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating serum al... 1 | 82
decreased circulating unsatura... 1 | 2
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased large unstained cell... 1 | 11
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged seminal vesicle 1 | 10
hydrops fetalis 1 | 1
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
small seminal vesicle 1 | 10
small spleen 1 | 19
small thymus 1 | 16
thrombocytosis 1 | 27

Disease

Carcinoma 67 | 11,493
ovarian cancer 65 | 8,520
osteosarcoma 53 | 7,950
psoriasis 48 | 6,694
glioblastoma 42 | 5,792
medulloblastoma, large-cell 42 | 6,241
atypical teratoid / rhabdoid tumor 34 | 5,112
lung cancer 33 | 4,740
ependymoma 28 | 4,679
malignant mesothelioma 26 | 3,232
Astrocytoma, Pilocytic 25 | 3,081
Cancer 25 | 2,499
invasive ductal carcinoma 24 | 2,951
adult high grade glioma 23 | 3,801
astrocytic glioma 23 | 2,597
lung carcinoma 23 | 2,843
Breast cancer 22 | 3,578
subependymal giant cell astrocytoma 22 | 2,287
Pick disease 21 | 1,894
oligodendroglioma 21 | 2,850
Multiple myeloma 20 | 1,332
non-small cell lung cancer 20 | 2,890
group 3 medulloblastoma 19 | 4,104
Kidney cancer 18 | 2,613
pancreatic cancer 18 | 2,398
Schizophrenia 15 | 1,160
lung adenocarcinoma 15 | 2,716
primitive neuroectodermal tumor 15 | 3,035
acute quadriplegic myopathy 14 | 1,158
diabetes mellitus 14 | 1,728
ductal carcinoma in situ 14 | 1,745
interstitial cystitis 14 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
pituitary cancer 14 | 1,972
Autosomal recessive predisposition 13 | 1,442
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Alzheimer's disease 12 | 658
Rheumatoid arthritis 12 | 1,191
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
cutaneous lupus erythematosus 11 | 1,057
breast carcinoma 10 | 1,638
cystic fibrosis 10 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Bipolar Disorder 9 | 666
Kidney disease 9 | 430
esophageal adenocarcinoma 9 | 737
tuberculosis 9 | 2,010
ulcerative colitis 9 | 1,819
Alcoholic Intoxication, Chronic 8 | 289
Cataract 8 multiple types 8 | 33
Hypertensive disease 8 | 292
Waldenstrons macroglobulinemia 8 | 765
pediatric high grade glioma 8 | 1,064
Atopic dermatitis 7 | 952
Depressive disorder 7 | 409
Diarrhea 7 | 253
Hypertension 7 | 396
Major Depressive Disorder 7 | 301
Obesity 7 | 678
acute myeloid leukemia 7 | 783
astrocytoma 7 | 1,146
dermatomyositis 7 | 966
juvenile dermatomyositis 7 | 1,187
non primary Sjogren syndrome sicca 7 | 891
primary pancreatic ductal adenocarcinoma 7 | 1,109
progressive supranuclear palsy 7 | 676
Epilepsy 6 | 792
Melanoma 6 | 711
Multiple Sclerosis 6 | 540
Unipolar Depression 6 | 250
aldosterone-producing adenoma 6 | 665
group 4 medulloblastoma 6 | 1,855
primary Sjogren syndrome 6 | 735
spina bifida 6 | 1,074
Anemia 5 | 365
Angina Pectoris 5 | 32
Breast Neoplasms 5 | 445
Dyspnea 5 | 76
Failure to gain weight 5 | 365
Gaucher disease type 1 5 | 180
Heart failure 5 | 162
Liver Cirrhosis, Experimental 5 | 769
Lung disease 5 | 142
Mammary Neoplasms 5 | 425
Mental Depression 5 | 333
Pediatric failure to thrive 5 | 365
Prostatic Neoplasms 5 | 495
Vascular disease 5 | 319
adrenocortical carcinoma 5 | 1,428
gastric carcinoma 5 | 807
pancreatic carcinoma 5 | 562
sarcoidosis 5 | 370
Atherosclerosis 4 | 291
Down syndrome 4 | 499
colon cancer 4 | 1,478
fibroadenoma 4 | 559
hepatocellular carcinoma 4 | 547
mucosa-associated lymphoid tissue lymphoma 4 | 484
nephrosclerosis 4 | 333
sonic hedgehog group medulloblastoma 4 | 467

Tissue

Skin and soft tissues 97 | 17,230
Digestive Tract 96 | 17,369
Endocrine System 96 | 18,159
Female tissues 96 | 17,400
Urinary Tract 96 | 16,678
Male tissues 95 | 17,142
Blood and immune system 94 | 16,909
Liver and Pancreas 94 | 16,750
Respiratory system 94 | 16,393
Nervous System 92 | 16,725
Cardiovascular System 88 | 15,192

Target Family

Non-IDG 82 | 12,091
GPCR 6 | 408
Enzyme 3 | 4,145
Kinase 3 | 634
Transporter 2 | 473
Ion Channel 1 | 344

Reactome Pathway

Cargo recognition for clathrin... 97 | 97
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
Epsin-1 EPN1 Tbio Non-IDG -1.52389 32.5 163
Vesicle-associated membrane protein 8 VAMP8 Tbio Non-IDG -1.79654 64.6 107
Synaptotagmin-11 SYT11 Tbio Non-IDG -1.00759 12.5 125
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248
Endophilin-A3 SH3GL3 Tbio Non-IDG -1.03962 9.87 97
Vasopressin-neurophysin 2-copeptin AVP Tbio Non-IDG -3.92570 8381.2 203
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
AP-2 complex subunit sigma AP2S1 Tbio Non-IDG -1.42073 25.5 108
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.59767 34.8 212