Development Level

Tbio 74 | 10,625
Tchem 12 | 1,890
Tclin 9 | 602
Tdark 2 | 7,003

IMPC Term

decreased total body fat amoun... 4 | 186
abnormal behavior 3 | 226
increased circulating HDL chol... 3 | 63
preweaning lethality, incomple... 3 | 260
cardiovascular system phenotyp... 2 | 35
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating serum al... 2 | 79
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased leukocyte cell numbe... 2 | 54
hypoactivity 2 | 89
increased circulating LDL chol... 2 | 15
increased circulating alkaline... 2 | 119
increased circulating potassiu... 2 | 31
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
preweaning lethality, complete... 2 | 633
thrombocytopenia 2 | 46
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal lens morphology 1 | 73
abnormal liver size 1 | 4
abnormal nail morphology 1 | 7
abnormal pericardium morpholog... 1 | 11
abnormal posture 1 | 5
absent pinna reflex 1 | 21
decreased basophil cell number 1 | 11
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating fructosa... 1 | 31
decreased effector memory CD4-... 1 | 6
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased granulocyte number 1 | 8
decreased heart rate 1 | 10
decreased heart rate variabili... 1 | 11
decreased hematocrit 1 | 25
decreased late germinal center... 1 | 2
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased myeloid cell number ... 1 | 1
decreased pre-pro B cell numbe... 1 | 2
decreased prepulse inhibition 1 | 52
decreased pro-B cell number 1 | 2
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged kidney 1 | 7
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
hyperactivity 1 | 108
impaired righting response 1 | 19
increased B cell number 1 | 23
increased T cell number 1 | 15
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased early germinal cente... 1 | 2
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased immature B cell numb... 1 | 1
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 25
increased or absent threshold ... 1 | 128
increased pre-B cell number 1 | 1
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
microphthalmia 1 | 15
short tibia 1 | 82
thrombocytosis 1 | 23

Disease

ovarian cancer 64 | 8,484
osteosarcoma 53 | 7,933
psoriasis 48 | 6,685
glioblastoma 43 | 5,572
medulloblastoma, large-cell 43 | 6,234
lung cancer 33 | 4,466
atypical teratoid / rhabdoid tumor 32 | 4,369
pilocytic astrocytoma 27 | 3,086
invasive ductal carcinoma 24 | 2,950
malignant mesothelioma 23 | 3,162
subependymal giant cell astrocytoma 23 | 2,287
Pick disease 22 | 1,893
lung carcinoma 22 | 2,844
oligodendroglioma 22 | 2,849
Cancer 21 | 2,346
Multiple myeloma 20 | 1,327
Breast cancer 19 | 3,094
pediatric high grade glioma 19 | 2,712
non-small cell lung cancer 18 | 2,798
Carcinoma 17 | 2,147
ependymoma 17 | 2,514
pancreatic cancer 17 | 2,300
astrocytoma 16 | 1,493
primitive neuroectodermal tumor 16 | 3,031
astrocytic glioma 15 | 2,241
acute quadriplegic myopathy 14 | 1,157
diabetes mellitus 14 | 1,663
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
lung adenocarcinoma 14 | 2,713
interstitial cystitis 13 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
pituitary cancer 13 | 1,972
Alzheimer's disease 12 | 644
Rheumatoid Arthritis 12 | 1,160
adult high grade glioma 12 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
breast carcinoma 10 | 1,614
cutaneous lupus erythematosus 10 | 1,056
medulloblastoma 10 | 1,524
posterior fossa group A ependymoma 10 | 1,511
Kidney disease 9 | 396
cystic fibrosis 9 | 1,665
esophageal adenocarcinoma 9 | 737
group 4 medulloblastoma 9 | 1,875
Waldenstrons macroglobulinemia 8 | 765
group 3 medulloblastoma 8 | 2,254
progressive supranuclear palsy 8 | 674
ulcerative colitis 8 | 2,087
Obesity 7 | 616
dermatomyositis 7 | 933
juvenile dermatomyositis 7 | 1,189
non primary Sjogren syndrome sicca 7 | 840
primary pancreatic ductal adenocarcinoma 7 | 1,271
sonic hedgehog group medulloblastoma 7 | 1,482
Atopic dermatitis 6 | 944
Hypertension 6 | 287
acute myeloid leukemia 6 | 780
aldosterone-producing adenoma 6 | 664
spina bifida 6 | 1,064
tuberculosis 6 | 1,557
Gaucher disease type 1 5 | 171
Mammary Neoplasms 5 | 410
Prostatic Neoplasms 5 | 471
adrenocortical carcinoma 5 | 1,427
atypical teratoid/rhabdoid tumor 5 | 1,095
pancreatic carcinoma 5 | 567
primary Sjogren syndrome 5 | 789
Alcohol dependence 4 | 107
Atherosclerosis 4 | 275
Autistic Disorder 4 | 320
Cardiomyopathies 4 | 90
Coronary artery disease 4 | 240
Diarrhea 4 | 155
Disease Progression 4 | 125
Down syndrome 4 | 548
Heart disease 4 | 279
Hypertensive disease 4 | 193
Liver carcinoma 4 | 217
Lung disease 4 | 132
Multiple Sclerosis 4 | 498
Parkinson's disease 4 | 364
Schizophrenia 4 | 501
Stomach Neoplasms 4 | 282
colon cancer 4 | 1,475
fibroadenoma 4 | 557
gastric cancer 4 | 430
gastric carcinoma 4 | 832
mucosa-associated lymphoid tissue lymphoma 4 | 480
nephrosclerosis 4 | 329
posterior fossa group B ependymoma 4 | 1,530
sarcoidosis 4 | 358
tuberculosis and treatment for 6 months 4 | 686
Duchenne muscular dystrophy 3 | 602
IGA Glomerulonephritis 3 | 454
Polycystic Ovary Syndrome 3 | 332
Type 2 diabetes mellitus 3 | 189
Vascular disease 3 | 281
hepatocellular carcinoma 3 | 532

Tissue

Blood and immune system 97 | 17,995
Cardiovascular System 97 | 17,958
Digestive Tract 97 | 18,473
Endocrine System 97 | 18,512
Female tissues 97 | 18,647
Liver and Pancreas 97 | 18,136
Nervous System 97 | 18,561
Skin and soft tissues 97 | 18,115
Urinary Tract 97 | 18,444
Respiratory system 96 | 17,484
Male tissues 95 | 17,969

Target Family

Non-IDG 81 | 11,971
GPCR 6 | 406
Kinase 4 | 634
Enzyme 3 | 4,146
Transporter 2 | 473
Ion Channel 1 | 341

Reactome Pathway

Cargo recognition for clathrin... 97 | 97
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Serotransferrin TF Tchem Non-IDG -4.13136 13124.3 952
Transferrin receptor protein 1 TFRC Tbio Non-IDG -3.39868 2437.0 1167
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Vesicle-associated membrane protein 7 VAMP7 Tbio Non-IDG -1.83769 81.7 133
COP9 signalosome complex subunit 2 COPS2 Tbio Non-IDG -0.87368 7.80 293
Cystic fibrosis transmembrane conductance regulator CFTR Tclin Ion Channel -3.74904 5988.4 267
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.63932 4.63 109