Development Level

Tbio 28 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal kidney morphology 2 | 65
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating free fat... 2 | 31
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
small testis 2 | 58
abnormal allantois morphology 1 | 8
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal left-right axis patte... 1 | 2
abnormal limb bud morphology 1 | 17
abnormal liver morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal somite shape 1 | 5
abnormal stomach morphology 1 | 10
abnormal tail bud morphology 1 | 8
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased fasted circulating g... 1 | 65
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged seminal vesicle 1 | 10
hydroencephaly 1 | 14
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating free fat... 1 | 20
increased mean corpuscular hem... 1 | 96
pale yolk sac 1 | 25
pallor 1 | 34

Disease

ovarian cancer 22 | 8,520
Carcinoma 20 | 11,493
osteosarcoma 20 | 7,950
medulloblastoma, large-cell 15 | 6,241
glioblastoma 13 | 5,792
lung cancer 12 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
psoriasis 12 | 6,694
Autosomal recessive predisposition 11 | 1,442
ependymoma 11 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
pancreatic cancer 11 | 2,398
atypical teratoid / rhabdoid tumor 10 | 5,112
invasive ductal carcinoma 10 | 2,951
Kidney cancer 9 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
non-small cell lung cancer 9 | 2,890
Breast cancer 8 | 3,578
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
lung adenocarcinoma 8 | 2,716
lung carcinoma 8 | 2,843
tuberculosis 8 | 2,010
Astrocytoma, Pilocytic 7 | 3,081
Multiple myeloma 7 | 1,332
malignant mesothelioma 7 | 3,232
pancreatic carcinoma 7 | 562
Cancer 6 | 2,499
Rheumatoid arthritis 6 | 1,191
adult high grade glioma 6 | 3,801
breast carcinoma 6 | 1,638
ulcerative colitis 6 | 1,819
Vascular disease 5 | 319
active Crohn's disease 5 | 922
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
group 3 medulloblastoma 5 | 4,104
primitive neuroectodermal tumor 5 | 3,035
spina bifida 5 | 1,074
Bipolar Disorder 4 | 666
Intellectual disability 4 | 1,016
astrocytic glioma 4 | 2,597
diabetes mellitus 4 | 1,728
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 807
non primary Sjogren syndrome sicca 4 | 891
oligodendroglioma 4 | 2,850
pituitary cancer 4 | 1,972
Acquired scoliosis 3 | 281
Congenital dyserythropoietic anemia 3 | 18
Curvature of spine 3 | 282
Dental caries 3 | 164
Elevated hepatic transaminases 3 | 81
Endometriosis 3 | 540
Epilepsy 3 | 792
Factor V deficiency 3 | 8
Factor VIII deficiency 3 | 10
Hepatic enzyme increased 3 | 81
Liver Dysfunction 3 | 99
Liver enzymes abnormal 3 | 81
Liver function test increased 3 | 81
Liver function tests abnormal finding 3 | 81
Melanoma 3 | 711
Muscle hypotonia 3 | 571
Pick disease 3 | 1,894
Rotting teeth 3 | 73
Schizophrenia 3 | 1,160
Short stature 3 | 531
Stomach Neoplasms 3 | 300
Subclinical abnormal liver function tests 3 | 81
Transaminases increased 3 | 81
atypical teratoid/rhabdoid tumor 3 | 357
dermatomyositis 3 | 966
gastric cancer 3 | 459
mucosa-associated lymphoid tissue lymphoma 3 | 484
nephrosclerosis 3 | 333
posterior fossa group A ependymoma 3 | 468
primary Sjogren syndrome 3 | 735
subependymal giant cell astrocytoma 3 | 2,287
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Amyotrophic lateral sclerosis 2 | 451
Anemia 2 | 365
Carcinoma, Hepatocellular 2 | 228
Colonic Neoplasms 2 | 142
Coronary artery disease 2 | 268
Diarrhea 2 | 253
Frontal bossing 2 | 157
Heart disease 2 | 306
Infantile onset 2 | 238
Liver Cirrhosis 2 | 181
Liver cancer 2 | 604
Liver carcinoma 2 | 240
Long philtrum 2 | 137
Major Depressive Disorder 2 | 301
Reflex, Deep Tendon, Absent 2 | 92
Skin cancer 2 | 469
active ulcerative colitis 2 | 764
hereditary spastic paraplegia 2 | 318

Tissue

Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Skin and soft tissues 32 | 17,230
Blood and immune system 31 | 16,909
Cardiovascular System 31 | 15,192
Respiratory system 31 | 16,393
Urinary Tract 31 | 16,678
Liver and Pancreas 30 | 16,750

Target Family

Non-IDG 28 | 12,091
Enzyme 3 | 4,145
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

Reactome Pathway

Cargo concentration in the ER 33 | 33
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.27566 1855.5 168
Melanoma inhibitory activity protein 2 CTAGE5 Tbio Non-IDG 0.00000 91
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.74914 5601.8 1083
Coagulation factor V F5 Tbio Non-IDG -2.73955 525.3 198
Protein ERGIC-53 LMAN1 Tbio Non-IDG -2.44907 270.7 118
Coagulation factor VIII F8 Tbio Non-IDG -3.59602 3983.5 652
Cathepsin Z CTSZ Tchem Enzyme -1.80363 70.2 233
Protein ERGIC-53-like LMAN1L Tbio Non-IDG -0.42233 2.28 79