Development Level

Tbio 65 | 11,445
Tclin 38 | 613
Tchem 25 | 1,598
Tdark 7 | 6,588

Collection

Ion Channel: IDG Consortium (T... 27 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 5 | 499
abnormal embryo size 4 | 220
impaired glucose tolerance 4 | 75
increased startle reflex 4 | 112
abnormal behavior 3 | 298
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
abnormal epididymis morphology 2 | 42
abnormal seminal vesicle morph... 2 | 114
decreased circulating alkaline... 2 | 46
decreased circulating calcium ... 2 | 36
decreased circulating glucose ... 2 | 126
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal facial morphology 1 | 17
abnormal head morphology 1 | 10
abnormal placenta vasculature 1 | 2
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal vibrissa morphology 1 | 25
absent vibrissae 1 | 12
cyanosis 1 | 7
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
embryonic lethality prior to o... 1 | 239
hemorrhage 1 | 23
increased body length 1 | 32
increased circulating fructosa... 1 | 13
increased circulating magnesiu... 1 | 10
increased kidney weight 1 | 6
increased mean platelet volume 1 | 45
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased vertical activity 1 | 24
prenatal lethality 1 | 28
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
short tibia 1 | 97
small epididymis 1 | 3

Disease

Carcinoma 95 | 11,493
medulloblastoma, large-cell 77 | 6,241
glioblastoma 67 | 5,792
atypical teratoid / rhabdoid tumor 66 | 5,112
ependymoma 60 | 4,679
osteosarcoma 58 | 7,950
psoriasis 58 | 6,694
adult high grade glioma 57 | 3,801
ovarian cancer 56 | 8,520
group 3 medulloblastoma 52 | 4,104
Astrocytoma, Pilocytic 51 | 3,081
oligodendroglioma 47 | 2,850
primitive neuroectodermal tumor 45 | 3,035
lung cancer 40 | 4,740
astrocytic glioma 39 | 2,597
subependymal giant cell astrocytoma 38 | 2,287
Kidney cancer 37 | 2,613
lung carcinoma 36 | 2,843
Pick disease 34 | 1,894
Atrial Fibrillation 32 | 124
Breast cancer 32 | 3,578
lung adenocarcinoma 31 | 2,716
pituitary cancer 31 | 1,972
malignant mesothelioma 28 | 3,232
Epilepsy 27 | 792
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
invasive ductal carcinoma 26 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
colon cancer 23 | 1,478
Hypertension 21 | 396
Heart disease 19 | 306
Autosomal recessive predisposition 18 | 1,442
pancreatic cancer 18 | 2,398
Brugada syndrome 17 | 29
Seizures 17 | 596
ductal carcinoma in situ 17 | 1,745
non-small cell lung cancer 17 | 2,890
cystic fibrosis 16 | 1,696
interstitial cystitis 16 | 2,312
Long QT syndrome 15 | 39
adrenocortical carcinoma 15 | 1,428
group 4 medulloblastoma 14 | 1,855
ulcerative colitis 14 | 1,819
Bipolar Disorder 13 | 666
Cerebellar Ataxia 13 | 304
Familial atrial fibrillation 13 | 23
Hypertensive disease 13 | 292
Skin cancer 13 | 469
Status Epilepticus 13 | 98
Ventricular arrhythmia 13 | 27
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 12 | 21
Cancer 12 | 2,499
Cardiomyopathy 12 | 116
Cognitive delay 12 | 608
Global developmental delay 12 | 608
Liver cancer 12 | 604
Melanoma 12 | 711
Mental and motor retardation 12 | 608
Muscle hypotonia 12 | 571
Schizophrenia 12 | 1,160
breast carcinoma 12 | 1,638
tuberculosis 12 | 2,010
Endometrial cancer 11 | 311
Life-Threatening Ventricular Tachycardia 11 | 15
Rheumatoid arthritis 11 | 1,191
acute quadriplegic myopathy 11 | 1,158
diabetes mellitus 11 | 1,728
Congestive heart failure 10 | 113
Cough 10 | 23
Dysuria 10 | 26
Epilepsy characterized by intractable complex partial seizures 10 | 28
Itching of skin 10 | 18
Lennox-Gastaut syndrome 10 | 34
Local anesthesia 10 | 40
Localization-related epilepsy 10 | 13
Malignant hyperthermia 10 | 26
Minor Skin Wound Pain 10 | 12
Motor cortex epilepsy 10 | 10
Mouth Irritation 10 | 12
Partial seizure 10 | 15
Prevent Minor Bacterial Skin Infection 10 | 10
Skin irritation 10 | 12
Sore throat symptom 10 | 12
Suppression of the Gag Reflex 10 | 12
Syncope 10 | 22
Tinea Infections 10 | 10
Tinea corporis 10 | 25
Tinea pedis 10 | 29
Tonic-clonic epilepsy 10 | 47
Urinary Tract Irritation 10 | 24
astrocytoma 10 | 1,146
Brugada Syndrome (disorder) 9 | 15
Cardiac Arrhythmia 9 | 103
Chronic heart failure 9 | 46
Heart conduction disease 9 | 83
Intellectual disability 9 | 1,016
Parkinson's disease 9 | 392
Postherpetic neuralgia 9 | 11
Prolonged QT interval 9 | 15

Tissue

Endocrine System 134 | 18,159
Digestive Tract 128 | 17,369
Female tissues 128 | 17,400
Nervous System 128 | 16,725
Male tissues 125 | 17,142
Skin and soft tissues 123 | 17,230
Blood and immune system 121 | 16,909
Urinary Tract 120 | 16,678
Liver and Pancreas 119 | 16,750
Respiratory system 119 | 16,393
Cardiovascular System 110 | 15,192

Target Family

Ion Channel 81 | 344
Transporter 17 | 473
Non-IDG 16 | 12,091
Kinase 10 | 634
Enzyme 7 | 4,145
Transcription Factor 3 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Cardiac conduction 135 | 135
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium channel protein type 10 subunit alpha SCN10A Tclin Ion Channel -3.17690 1469.3 126
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Potassium voltage-gated channel subfamily E member 3 KCNE3 Tbio Ion Channel -1.63683 41.4 75
Atrial natriuretic peptide-converting enzyme CORIN Tbio Non-IDG -2.14443 144.4 221
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Potassium voltage-gated channel subfamily D member 3 KCND3 Tclin Ion Channel -2.34610 217.9 162
Potassium voltage-gated channel subfamily E member 4 KCNE4 Tbio Ion Channel -1.17671 15.9 99
Sodium channel protein type 3 subunit alpha SCN3A Tclin Ion Channel -1.98160 87.0 76
FXYD domain-containing ion transport regulator 3 FXYD3 Tbio Ion Channel -1.78093 58.4 76
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308