Development Level

Tbio 56 | 10,625
Tclin 39 | 602
Tchem 36 | 1,890
Tdark 5 | 7,003

Collection

Eligible Ion Channel Proteins 31 | 117

IMPC Term

preweaning lethality, complete... 6 | 633
embryonic lethality prior to t... 3 | 187
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
abnormal epididymis morphology 2 | 31
decreased body weight 2 | 174
decreased circulating HDL chol... 2 | 77
decreased circulating calcium ... 2 | 33
decreased circulating choleste... 2 | 85
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
enlarged epididymis 2 | 27
impaired glucose tolerance 2 | 52
increased bone mineral content 2 | 92
increased circulating sodium l... 2 | 71
increased startle reflex 2 | 38
preweaning lethality, incomple... 2 | 260
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal facial morphology 1 | 9
abnormal forebrain development 1 | 18
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal maxilla morphology 1 | 16
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal placenta vasculature 1 | 2
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal sensory capabilities/... 1 | 3
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
absent vibrissae 1 | 14
cyanosis 1 | 6
decreased Ly6C low monocyte nu... 1 | 23
decreased bone mineral content 1 | 157
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased lumbar vertebrae num... 1 | 62
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
edema 1 | 11
hemorrhage 1 | 12
hyperactivity 1 | 108
increased caudal vertebrae num... 1 | 8
increased circulating fructosa... 1 | 11
increased circulating magnesiu... 1 | 10
increased effector memory CD4-... 1 | 15
increased kidney weight 1 | 4
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased plasma cell number 1 | 5
prenatal lethality 1 | 16
respiratory system phenotype 1 | 2
short tibia 1 | 82
small epididymis 1 | 3

Disease

medulloblastoma, large-cell 77 | 6,234
glioblastoma 64 | 5,572
osteosarcoma 58 | 7,933
psoriasis 58 | 6,685
atypical teratoid / rhabdoid tumor 56 | 4,369
ovarian cancer 56 | 8,484
pilocytic astrocytoma 51 | 3,086
oligodendroglioma 47 | 2,849
primitive neuroectodermal tumor 45 | 3,031
Carcinoma 39 | 2,147
lung cancer 38 | 4,466
subependymal giant cell astrocytoma 38 | 2,287
lung carcinoma 37 | 2,844
Pick disease 34 | 1,893
ependymoma 34 | 2,514
pediatric high grade glioma 34 | 2,712
astrocytic glioma 33 | 2,241
lung adenocarcinoma 32 | 2,713
pituitary cancer 31 | 1,972
Atrial Fibrillation 30 | 110
adult high grade glioma 30 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
invasive ductal carcinoma 27 | 2,950
malignant mesothelioma 27 | 3,162
Breast cancer 25 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,988
colon cancer 24 | 1,475
posterior fossa group A ependymoma 24 | 1,511
medulloblastoma 23 | 1,524
Epilepsy 22 | 346
sonic hedgehog group medulloblastoma 19 | 1,482
Long QT syndrome 18 | 52
ductal carcinoma in situ 18 | 1,745
group 3 medulloblastoma 18 | 2,254
Heart disease 17 | 279
group 4 medulloblastoma 17 | 1,875
non-small cell lung cancer 17 | 2,798
ulcerative colitis 17 | 2,087
astrocytoma 16 | 1,493
interstitial cystitis 16 | 2,299
Brugada syndrome 15 | 26
adrenocortical carcinoma 15 | 1,427
cystic fibrosis 15 | 1,665
Hypertension 14 | 287
pancreatic cancer 14 | 2,300
atypical teratoid/rhabdoid tumor 13 | 1,095
Cancer 12 | 2,346
Hypertensive disease 12 | 193
Status Epilepticus 12 | 85
breast carcinoma 12 | 1,614
Familial atrial fibrillation 11 | 16
Life-Threatening Ventricular Tachycardia 11 | 15
Rheumatoid Arthritis 11 | 1,160
Short QT syndrome 11 | 12
acute quadriplegic myopathy 11 | 1,157
Cough 10 | 21
Dysuria 10 | 24
Epilepsy characterized by intractable complex partial seizures 10 | 28
Itching of skin 10 | 19
Lennox-Gastaut syndrome 10 | 34
Local anesthesia 10 | 40
Localization-related epilepsy 10 | 13
Malignant hyperthermia 10 | 25
Minor Skin Wound Pain 10 | 12
Motor cortex epilepsy 10 | 10
Mouth Irritation 10 | 12
Partial seizure 10 | 15
Prevent Minor Bacterial Skin Infection 10 | 10
Skin irritation 10 | 12
Sore throat symptom 10 | 12
Suppression of the Gag Reflex 10 | 12
Timothy syndrome 10 | 12
Tinea Infections 10 | 10
Tinea corporis 10 | 25
Tinea pedis 10 | 30
Tonic-clonic epilepsy 10 | 47
Urinary Tract Irritation 10 | 24
Ventricular arrhythmia 10 | 14
diabetes mellitus 10 | 1,663
Brugada Syndrome (disorder) 9 | 15
Cardiomyopathy 9 | 110
Chronic heart failure 9 | 46
Congestive heart failure 9 | 30
Postherpetic neuralgia 9 | 12
non primary Sjogren syndrome sicca 9 | 840
posterior fossa group B ependymoma 9 | 1,530
Anesthesia for cesarean section 8 | 8
Atopic dermatitis 8 | 944
Down syndrome 8 | 548
Heart conduction disease 8 | 65
Major Nerve Block for Surgery 8 | 8
Obesity 8 | 616
Parkinson's disease 8 | 364
Regional Anesthesia for Postoperative Pain 8 | 9
Regional Anesthesia for Surgery 8 | 9
Simple partial seizure 8 | 26
Tonic-clonic seizure 8 | 11
active Crohn's disease 8 | 918
primary pancreatic ductal adenocarcinoma 8 | 1,271

Tissue

Nervous System 136 | 18,561
Female tissues 135 | 18,647
Cardiovascular System 134 | 17,958
Digestive Tract 134 | 18,473
Endocrine System 134 | 18,512
Liver and Pancreas 134 | 18,136
Urinary Tract 134 | 18,444
Blood and immune system 132 | 17,995
Male tissues 132 | 17,969
Skin and soft tissues 131 | 18,115
Respiratory system 130 | 17,484

Target Family

Ion Channel 81 | 341
Transporter 18 | 473
Non-IDG 16 | 11,971
Kinase 10 | 634
Enzyme 7 | 4,146
Transcription Factor 3 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Cardiac conduction 136 | 136
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.56223 31.9 51
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Homeodomain-interacting protein kinase 1 HIPK1 Tbio Kinase -0.62325 4.93 166
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
Sodium/potassium-transporting ATPase subunit alpha-2 ATP1A2 Tclin Transporter -2.04732 117.9 108
Voltage-dependent calcium channel gamma-7 subunit CACNG7 Tchem Ion Channel -0.48027 2.02 53
Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 Tchem Ion Channel -1.00872 12.4 65
Sodium/potassium-transporting ATPase subunit alpha-3 ATP1A3 Tclin Transporter -2.09703 131.9 103