Development Level

Tbio 111 | 11,651
Tdark 5 | 6,593
Tchem 4 | 1,388

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal spleen morphology 1 | 55
decreased circulating glucose ... 1 | 126
decreased granulocyte number 1 | 6
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
enlarged heart 1 | 210
hemorrhage 1 | 23
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
prolonged QT interval 1 | 38
short tibia 1 | 97

Disease

ovarian cancer 52 | 8,520
lung cancer 40 | 4,740
Multiple myeloma 34 | 1,332
diabetes mellitus 30 | 1,728
medulloblastoma, large-cell 30 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
Carcinoma 27 | 11,493
Diamond-Blackfan anemia 25 | 31
osteosarcoma 25 | 7,950
psoriasis 19 | 6,694
Waldenstrons macroglobulinemia 18 | 765
glioblastoma 18 | 5,792
atypical teratoid / rhabdoid tumor 17 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
acute quadriplegic myopathy 15 | 1,158
Breast cancer 14 | 3,578
group 3 medulloblastoma 14 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
sonic hedgehog group medulloblastoma 14 | 467
Abnormality of the urinary system 13 | 21
Anemia 13 | 365
Anemia, Diamond-Blackfan 13 | 16
Anemia, Macrocytic 13 | 18
Cardiac Arrhythmia 13 | 103
Cardiac conduction abnormalities 13 | 78
Cleft Palate 13 | 271
Conduction disorder of the heart 13 | 79
Delayed Puberty 13 | 97
EKG abnormalities 13 | 78
Electrocardiogram abnormal 13 | 81
Electrocardiogram change 13 | 78
Fatigue 13 | 182
Hand deformities 13 | 32
Intermittent migraine headaches 13 | 68
Migraine Disorders 13 | 76
Pallor 13 | 40
Uranostaphyloschisis 13 | 167
genital abnormal 13 | 17
reproductive system abnormality 13 | 17
Cancer 12 | 2,499
oligodendroglioma 12 | 2,850
malignant mesothelioma 11 | 3,232
cystic fibrosis 10 | 1,696
Adenocarcinoma of lung 9 | 142
acute myeloid leukemia 9 | 783
colon cancer 9 | 1,478
lung adenocarcinoma 9 | 2,716
Breast Neoplasms 8 | 445
Disease Progression 8 | 136
Mammary Neoplasms 8 | 425
Stomach Neoplasms 8 | 300
adult high grade glioma 8 | 3,801
astrocytoma 8 | 1,146
subependymal giant cell astrocytoma 8 | 2,287
Disease Models, Animal 7 | 155
Leukoencephalopathy with vanishing white matter 7 | 20
invasive ductal carcinoma 7 | 2,951
mucosa-associated lymphoid tissue lymphoma 7 | 484
non-small cell lung cancer 7 | 2,890
primitive neuroectodermal tumor 7 | 3,035
Astrocytoma, Pilocytic 6 | 3,081
Autosomal recessive predisposition 6 | 1,442
Epilepsy 6 | 792
Muscle hypotonia 6 | 571
Seizures 6 | 596
pancreatic cancer 6 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Big calvaria 5 | 147
Brain hypomyelination 5 | 11
Central nervous system demyelination 5 | 28
Delusions 5 | 11
Developmental regression 5 | 95
Duchenne muscular dystrophy 5 | 601
Dysarthria 5 | 192
Forgetful 5 | 40
Gait, Unsteady 5 | 29
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Lethargy 5 | 77
Leukodystrophy 5 | 55
Leukoencephalopathies 5 | 29
Loss of developmental milestones 5 | 95
Memory Loss 5 | 40
Memory impairment 5 | 40
Mental deterioration in childhood 5 | 95
Mood swings 5 | 77
Muscle Spasticity 5 | 195
Neurodevelopmental regression 5 | 95
Personality change 5 | 23
Premature Menopause 5 | 31
Prostatic Neoplasms 5 | 495
Psychomotor regression 5 | 95
Psychomotor regression beginning in infancy 5 | 95
Psychomotor regression in infants 5 | 95
Psychomotor regression, progressive 5 | 95
Reticulocytopenia 5 | 10
Secondary physiologic amenorrhea 5 | 32
hereditary spastic paraplegia 5 | 318
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Endocrine System 119 | 18,159
Blood and immune system 118 | 16,909
Digestive Tract 118 | 17,369
Male tissues 118 | 17,142
Skin and soft tissues 118 | 17,230
Cardiovascular System 117 | 15,192
Female tissues 117 | 17,400
Liver and Pancreas 117 | 16,750
Nervous System 117 | 16,725
Respiratory system 117 | 16,393
Urinary Tract 117 | 16,678

Target Family

Non-IDG 120 | 12,091

Reactome Pathway

Cap-dependent Translation Init... 120 | 120
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L17 RPL17 Tbio Non-IDG -1.22337 16.5 217
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tbio Non-IDG -2.81111 643.5 577
60S ribosomal protein L6 RPL6 Tbio Non-IDG -1.58528 37.8 68
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.68610 47.6 62
60S ribosomal protein L18 RPL18 Tbio Non-IDG -1.45984 25.8 149
40S ribosomal protein S7 RPS7 Tbio Non-IDG -1.84836 69.5 112
60S ribosomal protein L22-like 1 RPL22L1 Tdark Non-IDG -0.24304 2.12 15
Eukaryotic translation initiation factor 4E-binding protein 1 EIF4EBP1 Tbio Non-IDG -2.83637 578.9 1455
60S ribosomal protein L13 RPL13 Tbio Non-IDG -1.55331 35.0 96
40S ribosomal protein S27 RPS27 Tchem Non-IDG -1.48320 31.9 162