Development Level

Tbio 36 | 10,625
Tchem 15 | 1,890
Tdark 6 | 7,003
Tclin 3 | 602

IMPC Phenotype

preweaning lethality, complete... 5 | 633
preweaning lethality, incomple... 5 | 260
abnormal behavior 3 | 226
decreased body weight 2 | 174
decreased startle reflex 2 | 48
embryonic lethality prior to t... 2 | 187
hyperactivity 2 | 108
hypoactivity 2 | 89
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal forebrain development 1 | 18
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal response to tactile s... 1 | 16
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
cataract 1 | 26
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased body temperature 1 | 2
decreased bone mineral content 1 | 157
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased respiratory quotient 1 | 12
decreased total body fat amoun... 1 | 186
enlarged heart 1 | 111
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased B cell number 1 | 23
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased cellular hemoglobin ... 1 | 2
increased circulating alkaline... 1 | 119
increased circulating creatini... 1 | 29
increased circulating potassiu... 1 | 31
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased total body fat amoun... 1 | 57
macrophthalmia 1 | 2
male infertility 1 | 62
microphthalmia 1 | 15
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
small epididymis 1 | 3
small kidney 1 | 10
small superior vagus ganglion 1 | 20
syndactyly 1 | 4

Disease

ovarian cancer 34 | 8,491
osteosarcoma 32 | 7,933
medulloblastoma, large-cell 31 | 6,234
glioblastoma 30 | 5,572
psoriasis 29 | 6,685
atypical teratoid / rhabdoid tumor 28 | 4,369
primitive neuroectodermal tumor 23 | 3,031
pilocytic astrocytoma 22 | 3,086
lung cancer 21 | 4,473
Breast cancer 19 | 3,098
lung carcinoma 19 | 2,844
Pick disease 18 | 1,893
malignant mesothelioma 18 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
invasive ductal carcinoma 17 | 2,950
oligodendroglioma 17 | 2,849
subependymal giant cell astrocytoma 17 | 2,287
ependymoma 16 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,956
pediatric high grade glioma 16 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
lung adenocarcinoma 14 | 2,714
astrocytic glioma 13 | 2,241
non-small cell lung cancer 13 | 2,798
Cancer 11 | 2,346
breast carcinoma 11 | 1,614
ductal carcinoma in situ 11 | 1,745
group 4 medulloblastoma 11 | 1,875
astrocytoma 10 | 1,493
interstitial cystitis 10 | 2,299
medulloblastoma 10 | 1,524
pancreatic cancer 10 | 2,300
pituitary cancer 10 | 1,972
posterior fossa group A ependymoma 10 | 1,511
ulcerative colitis 10 | 2,087
Rheumatoid Arthritis 9 | 1,170
group 3 medulloblastoma 9 | 2,254
Carcinoma 8 | 2,147
Obesity 8 | 616
cystic fibrosis 8 | 1,670
juvenile dermatomyositis 8 | 1,189
posterior fossa group B ependymoma 8 | 1,530
sonic hedgehog group medulloblastoma 8 | 1,482
Colonic Neoplasms 7 | 126
adrenocortical carcinoma 7 | 1,427
colon cancer 7 | 1,475
primary pancreatic ductal adenocarcinoma 7 | 1,271
Prostatic Neoplasms 6 | 471
active Crohn's disease 6 | 918
acute myeloid leukemia 6 | 785
adult high grade glioma 6 | 2,148
tuberculosis 6 | 1,563
Multiple myeloma 5 | 1,327
cutaneous lupus erythematosus 5 | 1,056
sarcoidosis 5 | 368
Colorectal Neoplasms 4 | 217
Duchenne muscular dystrophy 4 | 602
acute quadriplegic myopathy 4 | 1,157
aldosterone-producing adenoma 4 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
diabetes mellitus 4 | 1,663
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 557
gastric carcinoma 4 | 832
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
spina bifida 4 | 1,064
Acquired metabolic disease 3 | 267
Alzheimer's disease 3 | 644
Atopic dermatitis 3 | 944
Atrial Fibrillation 3 | 110
Chronic heart failure 3 | 46
Cleft palate 3 | 125
Colorectal Cancer 3 | 62
Common variable immunodeficiency 3 | 98
Familial adenomatous polyposis 3 | 33
Hepatolenticular Degeneration 3 | 24
Intellectual disability 3 | 573
Left Ventricular Hypertrophy 3 | 24
Lung Neoplasms 3 | 171
MYELODYSPLASTIC SYNDROME 3 | 39
Myocardial Perfusion Imaging Adjunct 3 | 25
Osteoporosis 3 | 259
Peripheral Neuropathy 3 | 303
Platelet Aggregation Inhibition 3 | 22
Prevention of Cerebral Thrombosis 3 | 29
Retinitis pigmentosa 3 | 156
Schizophrenia 3 | 503
atypical teratoid/rhabdoid tumor 3 | 1,095
chronic lymphocytic leukemia 3 | 244
glioblastoma multiforme 3 | 347
hepatocellular carcinoma 3 | 550
non primary Sjogren syndrome sicca 3 | 840
non-inflammatory breast cancer 3 | 208
non-small cell lung carcinoma 3 | 413
pancreatic carcinoma 3 | 567
primary Sjogren syndrome 3 | 788
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 3 months 3 | 327
tuberculosis and treatment for 6 months 3 | 686
dermatomyositis 2 | 966

Tissue

Blood and immune system 60 | 17,994
Digestive Tract 60 | 18,472
Endocrine System 60 | 18,511
Female tissues 60 | 18,646
Liver and Pancreas 60 | 18,135
Male tissues 60 | 17,968
Nervous System 60 | 18,560
Skin and soft tissues 60 | 18,114
Urinary Tract 60 | 18,443
Cardiovascular System 59 | 17,957
Respiratory system 58 | 17,483

Target Family

Non-IDG 31 | 11,969
Enzyme 9 | 4,146
Kinase 6 | 634
Transcription Factor 6 | 1,400
GPCR 5 | 408
Ion Channel 3 | 341

Reactome Pathway

Ca2+ pathway 60 | 60
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Trinucleotide repeat-containing gene 6B protein TNRC6B Tbio Non-IDG -0.97375 6.84 59
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.86049 63.7 252
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.12987 136.7 95
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.67695 418.8 220
Frizzled-4 FZD4 Tbio GPCR -2.00958 92.5 273
Guanine nucleotide-binding protein G(T) subunit gamma-T1 GNGT1 Tbio Non-IDG -1.40499 21.6 57
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 GNG5 Tbio Non-IDG -0.57807 3.96 74
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 GNG3 Tdark Non-IDG -0.61010 4.53 40
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.41371 28.0 678