Development Level

Tbio 40 | 11,651
Tchem 12 | 1,388
Tdark 4 | 6,593
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 9 | 979
enlarged heart 7 | 210
abnormal heart morphology 5 | 162
preweaning lethality, incomple... 5 | 499
embryonic lethality prior to t... 4 | 278
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
decreased lymphocyte cell numb... 2 | 83
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
enlarged spleen 2 | 41
hyperactivity 2 | 148
increased monocyte cell number 2 | 63
microphthalmia 2 | 26
small superior vagus ganglion 2 | 74
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal duodenum morphology 1 | 4
abnormal embryo development 1 | 7
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal response to tactile s... 1 | 17
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
hydrometra 1 | 53
hydrops fetalis 1 | 1
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased B cell number 1 | 9
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cellular hemoglobin ... 1 | 1
increased circulating creatini... 1 | 38
increased circulating insulin ... 1 | 3
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
macrophthalmia 1 | 2
male infertility 1 | 123
mammalian phenotype 1 | 17
polydactyly 1 | 7
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
protruding tongue 1 | 3
small epididymis 1 | 3
small kidney 1 | 16
syndactyly 1 | 23

Disease

Carcinoma 41 | 11,493
ovarian cancer 34 | 8,520
osteosarcoma 32 | 7,950
ependymoma 31 | 4,679
glioblastoma 31 | 5,792
medulloblastoma, large-cell 31 | 6,241
atypical teratoid / rhabdoid tumor 29 | 5,112
psoriasis 29 | 6,694
Breast cancer 23 | 3,578
primitive neuroectodermal tumor 23 | 3,035
Astrocytoma, Pilocytic 22 | 3,081
lung cancer 20 | 4,740
astrocytic glioma 19 | 2,597
lung carcinoma 19 | 2,843
malignant mesothelioma 19 | 3,232
Pick disease 17 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
invasive ductal carcinoma 17 | 2,951
oligodendroglioma 17 | 2,850
subependymal giant cell astrocytoma 17 | 2,287
adult high grade glioma 15 | 3,801
group 3 medulloblastoma 15 | 4,104
group 4 medulloblastoma 15 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
Kidney cancer 14 | 2,613
lung adenocarcinoma 14 | 2,716
non-small cell lung cancer 14 | 2,890
breast carcinoma 12 | 1,638
Cancer 11 | 2,499
ductal carcinoma in situ 11 | 1,745
interstitial cystitis 10 | 2,312
pancreatic cancer 10 | 2,398
pituitary cancer 10 | 1,972
tuberculosis 10 | 2,010
Rheumatoid arthritis 9 | 1,191
Schizophrenia 9 | 1,160
ulcerative colitis 9 | 1,819
Autosomal recessive predisposition 8 | 1,442
Intellectual disability 8 | 1,016
Obesity 8 | 678
cystic fibrosis 8 | 1,696
juvenile dermatomyositis 8 | 1,187
Bipolar Disorder 7 | 666
Colonic Neoplasms 7 | 142
adrenocortical carcinoma 7 | 1,428
colon cancer 7 | 1,478
pediatric high grade glioma 7 | 1,064
Dull intelligence 6 | 645
Liver cancer 6 | 604
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Prostatic Neoplasms 6 | 495
active Crohn's disease 6 | 922
acute myeloid leukemia 6 | 783
primary pancreatic ductal adenocarcinoma 6 | 1,109
Abnormality of retinal pigmentation 5 | 111
Colorectal Neoplasms 5 | 243
Congenital hypoplasia of penis 5 | 176
Multiple myeloma 5 | 1,332
Retinal pigment epithelial abnormality 5 | 111
cutaneous lupus erythematosus 5 | 1,057
diabetes mellitus 5 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
sarcoidosis 5 | 370
Anteverted nostril 4 | 191
Blind Vision 4 | 111
Blindness, Legal 4 | 110
Broad flat nasal bridge 4 | 236
Cognitive delay 4 | 608
Conductive hearing loss 4 | 123
Disease Models, Animal 4 | 155
Duchenne muscular dystrophy 4 | 601
Electroretinogram abnormal 4 | 95
Global developmental delay 4 | 608
Keratoconus 4 | 113
Mental and motor retardation 4 | 608
Nasal bridge wide 4 | 236
Neurodevelopmental Disorders 4 | 70
Nystagmus 4 | 317
Photodysphoria 4 | 121
Photophobia 4 | 121
Sensorineural Hearing Loss (disorder) 4 | 284
acute quadriplegic myopathy 4 | 1,158
aldosterone-producing adenoma 4 | 665
astrocytoma 4 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 559
gastric carcinoma 4 | 807
medulloblastoma 4 | 720
spina bifida 4 | 1,074
Alzheimer's disease 3 | 658
Depressive disorder 3 | 409
Glaucoma 3 | 239
hepatocellular carcinoma 3 | 547
pancreatic carcinoma 3 | 562
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Blood and immune system 58 | 16,909
Digestive Tract 58 | 17,369
Endocrine System 58 | 18,159
Female tissues 57 | 17,400
Male tissues 57 | 17,142
Nervous System 57 | 16,725
Skin and soft tissues 57 | 17,230
Liver and Pancreas 56 | 16,750
Respiratory system 56 | 16,393
Urinary Tract 56 | 16,678
Cardiovascular System 55 | 15,192

Target Family

Non-IDG 30 | 12,091
Enzyme 9 | 4,145
Kinase 6 | 634
Transcription Factor 6 | 1,400
GPCR 5 | 408
Ion Channel 3 | 344

Reactome Pathway

Ca2+ pathway 59 | 59
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161
Protein argonaute-2 AGO2 Tbio Non-IDG -2.97243 867.1 202
Trinucleotide repeat-containing gene 6C protein TNRC6C Tbio Non-IDG -0.67756 3.07 30
Frizzled-4 FZD4 Tbio GPCR -2.05508 106.8 313
Guanine nucleotide-binding protein G(T) subunit gamma-T1 GNGT1 Tbio Non-IDG -1.43842 22.5 61
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 GNG3 Tdark Non-IDG -0.61010 4.53 48
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.70325 459.4 238
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Trinucleotide repeat-containing gene 6A protein TNRC6A Tbio Non-IDG -2.08032 118.3 77