Development Level

Tclin 8 | 613
Tbio 7 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

abnormal behavior 2 | 298
increased neutrophil cell numb... 2 | 46
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal locomotor behavior 1 | 24
abnormal maxilla morphology 1 | 17
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
short tibia 1 | 97
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 18 | 11,493
osteosarcoma 15 | 7,950
ovarian cancer 14 | 8,520
Cancer 13 | 2,499
glioblastoma 11 | 5,792
medulloblastoma, large-cell 11 | 6,241
psoriasis 10 | 6,694
adult high grade glioma 8 | 3,801
Breast cancer 7 | 3,578
interstitial cystitis 7 | 2,312
invasive ductal carcinoma 7 | 2,951
lung cancer 7 | 4,740
diabetes mellitus 6 | 1,728
ependymoma 6 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
subependymal giant cell astrocytoma 6 | 2,287
ulcerative colitis 6 | 1,819
Blastic phase chronic myeloid leukemia 5 | 58
Chronic Myelocytic Leukemia Accelerated Phase 5 | 59
Multiple myeloma 5 | 1,332
Rheumatoid arthritis 5 | 1,191
atypical teratoid / rhabdoid tumor 5 | 5,112
cutaneous lupus erythematosus 5 | 1,057
group 4 medulloblastoma 5 | 1,855
primary Sjogren syndrome 5 | 735
tuberculosis 5 | 2,010
Allergic hypersensitivity disease 4 | 126
Asthma 4 | 385
Astrocytoma, Pilocytic 4 | 3,081
Chronic Lymphocytic Leukemia 4 | 262
Chronic phase chronic myeloid leukemia 4 | 45
Epilepsy 4 | 792
Hypersensitivity reaction type II disease 4 | 253
Kidney cancer 4 | 2,613
Orbital separation excessive 4 | 244
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 4 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 4 | 47
Seizures 4 | 596
Waldenstrons macroglobulinemia 4 | 765
astrocytic glioma 4 | 2,597
astrocytoma 4 | 1,146
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
Autosomal recessive predisposition 3 | 1,442
Bipolar Disorder 3 | 666
Celiac disease 3 | 116
Dermatitis 3 | 157
Dilated ventricles (finding) 3 | 121
Down syndrome 3 | 499
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 645
Hepatitis B 3 | 108
Hepatomegaly 3 | 285
Human immunodeficiency virus infectious disease 3 | 138
Hydrocephalus 3 | 152
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Lymphoproliferative syndrome 3 | 58
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Multiple Sclerosis 3 | 540
Pick disease 3 | 1,894
Poor school performance 3 | 645
Primary immunodeficiency disease 3 | 54
Stomach Neoplasms 3 | 300
Ventricular Septal Defects 3 | 119
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
juvenile dermatomyositis 3 | 1,187
malignant mesothelioma 3 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Anemia 2 | 365
Arthritis 2 | 290
Atopic dermatitis 2 | 952
Diarrhea 2 | 253
Inflammatory bowel disease 2 | 151
Kidney disease 2 | 430
Liver Cirrhosis, Experimental 2 | 769
Neurodevelopmental Disorders 2 | 70
Pectus excavatum 2 | 100
Schizophrenia 2 | 1,160
Strabismus 2 | 270
adrenocortical carcinoma 2 | 1,428
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 559
gastric carcinoma 2 | 807
hereditary spastic paraplegia 2 | 318
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
progressive supranuclear palsy 2 | 676
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 20 | 16,909
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678
Cardiovascular System 19 | 15,192

Target Family

Enzyme 10 | 4,145
Kinase 7 | 634
Non-IDG 3 | 12,091

Reactome Pathway

CTLA4 inhibitory signaling 20 | 20
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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