Development Level

Tclin 8 | 602
Tbio 7 | 10,625
Tchem 7 | 1,890

IMPC Phenotype

abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 5
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating choleste... 1 | 85
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased neutrophil cell numb... 1 | 37
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
male infertility 1 | 62
preweaning lethality, complete... 1 | 633
thrombocytosis 1 | 23

Disease

osteosarcoma 16 | 7,933
ovarian cancer 16 | 8,491
Cancer 15 | 2,346
medulloblastoma, large-cell 12 | 6,234
glioblastoma 11 | 5,572
psoriasis 10 | 6,685
Breast cancer 7 | 3,098
interstitial cystitis 7 | 2,299
invasive ductal carcinoma 7 | 2,950
lung cancer 7 | 4,473
subependymal giant cell astrocytoma 7 | 2,287
adult high grade glioma 6 | 2,148
atypical teratoid / rhabdoid tumor 6 | 4,369
diabetes mellitus 6 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
ulcerative colitis 6 | 2,087
Asthma 5 | 349
Blastic phase chronic myeloid leukemia 5 | 58
Chronic Myelocytic Leukemia Accelerated Phase 5 | 59
Multiple myeloma 5 | 1,327
Rheumatoid Arthritis 5 | 1,170
astrocytic glioma 5 | 2,241
cutaneous lupus erythematosus 5 | 1,056
ependymoma 5 | 2,514
pediatric high grade glioma 5 | 2,712
pilocytic astrocytoma 5 | 3,086
primary Sjogren syndrome 5 | 788
Allergic hypersensitivity disease 4 | 123
Chronic phase chronic myeloid leukemia 4 | 45
Hypersensitivity reaction type II disease 4 | 235
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 4 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 4 | 47
Waldenstrons macroglobulinemia 4 | 764
astrocytoma 4 | 1,493
cystic fibrosis 4 | 1,670
dermatomyositis 4 | 966
group 4 medulloblastoma 4 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
lung adenocarcinoma 4 | 2,714
lung carcinoma 4 | 2,844
oligodendroglioma 4 | 2,849
pancreatic cancer 4 | 2,300
tuberculosis and treatment for 6 months 4 | 686
Arthritis 3 | 248
Carcinoma 3 | 2,147
Celiac disease 3 | 112
Dermatitis 3 | 141
Down syndrome 3 | 548
Hepatitis B 3 | 103
Human immunodeficiency virus infectious disease 3 | 129
Inflammatory bowel disease 3 | 142
Intellectual disability 3 | 573
Kidney disease 3 | 397
Liver disease 3 | 219
Mammary Neoplasms 3 | 410
Multiple Sclerosis 3 | 498
Pick disease 3 | 1,893
breast carcinoma 3 | 1,614
chronic lymphocytic leukemia 3 | 244
colon cancer 3 | 1,475
group 3 medulloblastoma 3 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
juvenile dermatomyositis 3 | 1,189
malignant mesothelioma 3 | 3,163
medulloblastoma 3 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
primitive neuroectodermal tumor 3 | 3,031
tuberculosis 3 | 1,563
Adult T-Cell Lymphoma/Leukemia 2 | 30
Alzheimer's disease 2 | 644
Atopic dermatitis 2 | 944
Carcinoma of colon 2 | 32
Cardiomegaly 2 | 66
Colitis 2 | 46
Epilepsy 2 | 346
IGA Glomerulonephritis 2 | 454
Influenza 2 | 142
Lung Neoplasms 2 | 171
Lung disease 2 | 136
Lymphoid leukemia 2 | 69
Obesity 2 | 616
Osteoporosis 2 | 259
Schizophrenia 2 | 503
Stomach Neoplasms 2 | 282
Tetanus 2 | 66
Vascular disease 2 | 281
adrenocortical carcinoma 2 | 1,427
chronic lymphosyte leukemia 2 | 232
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 557
gastric cancer 2 | 436
gastric carcinoma 2 | 832
head and neck cancer and chronic obstructive pulmonary disease 2 | 237
hereditary spastic paraplegia 2 | 313
nasopharyngeal carcinoma 2 | 1,056
non-small cell lung cancer 2 | 2,798
pituitary cancer 2 | 1,972
progressive supranuclear palsy 2 | 674
systemic lupus erythematosus 2 | 172

Tissue

Blood and immune system 22 | 17,994
Cardiovascular System 22 | 17,957
Digestive Tract 22 | 18,472
Endocrine System 22 | 18,511
Female tissues 22 | 18,646
Liver and Pancreas 22 | 18,135
Male tissues 22 | 17,968
Nervous System 22 | 18,560
Respiratory system 22 | 17,483
Skin and soft tissues 22 | 18,114
Urinary Tract 22 | 18,443

Target Family

Enzyme 10 | 4,146
Kinase 9 | 634
Non-IDG 3 | 11,969

Reactome Pathway

CTLA4 inhibitory signaling 22 | 22
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform PPP2R1A Tbio Enzyme -1.40388 25.3 259
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 17.1 179
Tyrosine-protein kinase Yes YES1 Tclin Kinase -2.02315 100.2 381
Tyrosine-protein kinase Lyn LYN Tclin Kinase -2.82112 659.3 521
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -3.98540 8801.0 1257
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.09500 191.5 579
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.08398 1308.8 971
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB Tbio Enzyme -1.13088 11.1 226
Tyrosine-protein kinase Fyn FYN Tclin Kinase -3.01286 981.0 618
Tyrosine-protein kinase Lck LCK Tclin Kinase -3.16488 1465.1 1025