Development Level

Tbio 6 | 11,651
Tchem 1 | 1,388
Tdark 1 | 6,593

IMPC Phenotype

increased circulating alkaline... 1 | 122

Disease

Carcinoma 7 | 11,493
osteosarcoma 5 | 7,950
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
lung cancer 4 | 4,740
medulloblastoma, large-cell 4 | 6,241
ovarian cancer 4 | 8,520
psoriasis 4 | 6,694
group 3 medulloblastoma 3 | 4,104
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
Carcinoma, Hepatocellular 2 | 228
Fibromyxosarcoma 2 | 3
Fibrosarcoma 2 | 14
Liver carcinoma 2 | 240
Perineurioma 2 | 4
Prostatic Neoplasms 2 | 495
Sarcoma 2 | 62
adult high grade glioma 2 | 3,801
breast carcinoma 2 | 1,638
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Abnormal vertebral bodies 1 | 16
Absent eyebrow 1 | 13
Absent eyelashes 1 | 16
Agenesis of eyebrows 1 | 13
Alveolar soft part sarcoma 1 | 10
Amyloidosis 1 | 67
Aplasia of eyebrows 1 | 13
Aplasia of eyelashes 1 | 16
Asymmetry of the posterior cranium 1 | 20
Blepharitis 1 | 23
Blushing 1 | 4
Bone cancer 1 | 16
Cellulitis of eyelid 1 | 17
Chondrosarcoma 1 | 21
Cloudy cornea 1 | 33
Congenital anomaly of spine 1 | 16
Congenital hemivertebra 1 | 25
Congenital hypoplasia of kidney 1 | 32
Conjunctivitis 1 | 53
Conjunctivitis, recurrent 1 | 37
Convex nasal ridge 1 | 37
Corneal stromal opacities 1 | 33
Crimean-Congo hemorrhagic fever 1 | 9
Cutaneous fibrous histiocytoma 1 | 17
Dystrophic fingernails 1 | 18
Ectodermal Dysplasia 1 | 14
Ectropion 1 | 38
Exfoliative dermatitis 1 | 24
Failure of development of eyelashes 1 | 16
Fibrous histiocytoma 1 | 7
Flattening of cranial vault 1 | 20
Flattening of head 1 | 20
Hemangiopericytoma 1 | 5
Keratosis 1 | 37
Lassa fever 1 | 9
Leiomyosarcoma 1 | 24
Liposarcoma 1 | 20
Madarosis of eyebrow 1 | 13
Malignant fibroxanthoma 1 | 7
Malignant peripheral nerve sheath tumor 1 | 12
Mucocele of salivary gland 1 | 5
Multiple vertebral anomalies 1 | 16
Neonatal Death 1 | 14
Neoplasm Recurrence, Local 1 | 37
Neurilemmoma 1 | 23
Neurofibroma 1 | 8
Olivopontocerebellar Atrophies 1 | 6
Ossifying fibromyxoid tumor 1 | 5
Osteitis Deformans 1 | 11
Osteogenesis imperfecta 1 | 34
Osteogenesis imperfecta type III (disorder) 1 | 11
Paget's disease of bone 1 | 36
Palmoplantar keratosis 1 | 74
Parakeratosis 1 | 7
Phrynoderma 1 | 11
Plagiocephaly 1 | 20
Plagiocephaly, Nonsynostotic 1 | 20
Polyneuropathy 1 | 64
Pseudosarcomatous fibromatosis 1 | 8
Rhabdomyosarcoma 1 | 39
Rhomboid shaped head 1 | 20
Rosacea 1 | 25
Scarring alopecia of scalp 1 | 13
Small testicle 1 | 75
Sparse eyebrow 1 | 42
Sparse eyelashes 1 | 31
Synovial sarcoma 1 | 25
Unilateral agenesis of kidney 1 | 20
Vesico-Ureteral Reflux 1 | 33
X- linked recessive 1 | 110
osteogenesis imperfecta type 3 1 | 11

Tissue

Blood and immune system 8 | 16,909
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Nervous System 8 | 16,725
Urinary Tract 8 | 16,678
Male tissues 7 | 17,142
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Cardiovascular System 6 | 15,192

Target Family

Transcription Factor 4 | 1,400
Enzyme 2 | 4,145
Non-IDG 2 | 12,091

Reactome Pathway

CREB3 factors activate genes 8 | 8
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Membrane-bound transcription factor site-2 protease MBTPS2 Tbio Enzyme -1.94015 86.1 119
Membrane-bound transcription factor site-1 protease MBTPS1 Tchem Enzyme -1.49326 34.9 64
CREB3 regulatory factor CREBRF Tdark Non-IDG -0.98415 6.02 21
Cyclic AMP-responsive element-binding protein 3-like protein 1 CREB3L1 Tbio Transcription Factor -1.53171 30.7 215
Dendritic cell-specific transmembrane protein DCSTAMP Tbio Non-IDG -2.01301 97.3 42
Cyclic AMP-responsive element-binding protein 3-like protein 2 CREB3L2 Tbio Transcription Factor -2.52262 324.1 178
Cyclic AMP-responsive element-binding protein 3-like protein 3 CREB3L3 Tbio Transcription Factor -1.51965 41.5 33
Cyclic AMP-responsive element-binding protein 3-like protein 4 CREB3L4 Tbio Transcription Factor -1.64875 47.6 188