Development Level

Tbio 67 | 11,445
Tdark 13 | 6,588
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 16 | 979
embryonic lethality prior to t... 5 | 278
decreased circulating choleste... 3 | 93
embryonic lethality prior to o... 3 | 239
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased body weight 2 | 161
decreased caudal vertebrae num... 2 | 53
decreased lactate dehydrogenas... 2 | 16
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
small testis 2 | 58
abnormal allantois morphology 1 | 8
abnormal behavior 1 | 298
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal left-right axis patte... 1 | 2
abnormal limb bud morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged seminal vesicle 1 | 10
hydroencephaly 1 | 14
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
thrombocytosis 1 | 27

Disease

ovarian cancer 51 | 8,520
Carcinoma 43 | 11,493
osteosarcoma 40 | 7,950
glioblastoma 39 | 5,792
psoriasis 30 | 6,694
medulloblastoma, large-cell 27 | 6,241
ependymoma 26 | 4,679
Breast cancer 25 | 3,578
atypical teratoid / rhabdoid tumor 25 | 5,112
lung cancer 21 | 4,740
Multiple myeloma 19 | 1,332
adult high grade glioma 19 | 3,801
lung adenocarcinoma 18 | 2,716
Kidney cancer 17 | 2,613
group 3 medulloblastoma 17 | 4,104
Astrocytoma, Pilocytic 16 | 3,081
diabetes mellitus 16 | 1,728
malignant mesothelioma 16 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
primitive neuroectodermal tumor 14 | 3,035
acute quadriplegic myopathy 13 | 1,158
dermatomyositis 13 | 966
astrocytic glioma 12 | 2,597
non-small cell lung cancer 12 | 2,890
oligodendroglioma 12 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
invasive ductal carcinoma 11 | 2,951
pancreatic cancer 11 | 2,398
group 4 medulloblastoma 10 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
subependymal giant cell astrocytoma 10 | 2,287
Autosomal recessive predisposition 9 | 1,442
Pick disease 9 | 1,894
astrocytoma 9 | 1,146
breast carcinoma 9 | 1,638
acute myeloid leukemia 8 | 783
juvenile dermatomyositis 8 | 1,187
lung carcinoma 8 | 2,843
non primary Sjogren syndrome sicca 8 | 891
tuberculosis 8 | 2,010
Congenital disorder of glycosylation 7 | 54
Duchenne muscular dystrophy 7 | 601
Intellectual disability 7 | 1,016
adrenocortical carcinoma 7 | 1,428
spina bifida 7 | 1,074
Anemia 6 | 365
Endometrial cancer 6 | 311
Liver cancer 6 | 604
Muscle hypotonia 6 | 571
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
esophageal adenocarcinoma 6 | 737
hepatocellular carcinoma 6 | 547
pituitary cancer 6 | 1,972
primary pancreatic ductal adenocarcinoma 6 | 1,109
tuberculosis and treatment for 6 months 6 | 409
Cancer 5 | 2,499
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Epilepsy 5 | 792
Global developmental delay 5 | 608
Low intelligence 5 | 645
Melanoma 5 | 711
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Neuropathy 5 | 261
Poor school performance 5 | 645
colon cancer 5 | 1,478
cutaneous lupus erythematosus 5 | 1,057
ductal carcinoma in situ 5 | 1,745
pediatric high grade glioma 5 | 1,064
sonic hedgehog group medulloblastoma 5 | 467
Anemia, Hemolytic 4 | 55
Bipolar Disorder 4 | 666
Congenital hemolytic anemia 4 | 32
Down syndrome 4 | 499
Heart disease 4 | 306
Menkes disease 4 | 19
Neurodegenerative disease 4 | 414
Polycystic ovary syndrome 4 | 360
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
Seizures 4 | 596
Waldenstrons macroglobulinemia 4 | 765
cystic fibrosis 4 | 1,696
pancreatic carcinoma 4 | 562
posterior fossa group B ependymoma 4 | 416
Atopic dermatitis 3 | 952
Atrophy of cerebellum 3 | 103
Cerebellar degeneration 3 | 103
Immune system cancer 3 | 140
Infantile onset 3 | 238
Infratentorial atrophy 3 | 103
Prostatic Neoplasms 3 | 495
Skin cancer 3 | 469
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
gastric cancer 3 | 459
interstitial cystitis 3 | 2,312

Tissue

Endocrine System 82 | 18,159
Female tissues 82 | 17,400
Liver and Pancreas 82 | 16,750
Skin and soft tissues 82 | 17,230
Blood and immune system 81 | 16,909
Digestive Tract 81 | 17,369
Urinary Tract 81 | 16,678
Cardiovascular System 80 | 15,192
Male tissues 80 | 17,142
Nervous System 80 | 16,725
Respiratory system 80 | 16,393

Target Family

Non-IDG 72 | 12,091
Enzyme 10 | 4,145

Reactome Pathway

COPI-mediated anterograde tran... 82 | 82
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303
Alpha-soluble NSF attachment protein NAPA Tbio Non-IDG -1.91664 86.4 148
Conserved oligomeric Golgi complex subunit 1 COG1 Tbio Non-IDG -1.68066 45.6 91
Ankyrin-2 ANK2 Tbio Non-IDG -2.08421 120.5 236
Transmembrane protein 115 TMEM115 Tbio Non-IDG -1.77886 56.2 83
ADP-ribosylation factor 3 ARF3 Tbio Enzyme -2.38391 168.3 82
Spectrin beta chain, non-erythrocytic 2 SPTBN2 Tbio Non-IDG -1.73436 53.8 237
Golgin subfamily B member 1 GOLGB1 Tbio Non-IDG -2.75385 540.5 88
Transmembrane emp24 domain-containing protein 9 TMED9 Tdark Non-IDG -0.03714 0.58 112
Spectrin alpha chain, non-erythrocytic 1 SPTAN1 Tbio Non-IDG -2.42514 269.0 268