Development Level

Tbio 24 | 11,445
Tdark 6 | 6,588
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased circulating alanine ... 2 | 47
decreased total body fat amoun... 2 | 207
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased lactate dehydrogenas... 1 | 16
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased circulating creatini... 1 | 38
increased hematocrit 1 | 46
increased startle reflex 1 | 112
limb grasping 1 | 41
male infertility 1 | 123
microphthalmia 1 | 26
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38
prolonged RR interval 1 | 8
prolonged ST segment 1 | 36

Disease

ovarian cancer 22 | 8,520
Carcinoma 20 | 11,493
osteosarcoma 19 | 7,950
atypical teratoid / rhabdoid tumor 13 | 5,112
glioblastoma 13 | 5,792
medulloblastoma, large-cell 12 | 6,241
psoriasis 12 | 6,694
Breast cancer 11 | 3,578
lung cancer 11 | 4,740
ependymoma 9 | 4,679
Pick disease 8 | 1,894
adult high grade glioma 7 | 3,801
astrocytoma 7 | 1,146
group 3 medulloblastoma 7 | 4,104
Multiple myeloma 6 | 1,332
Muscle hypotonia 6 | 571
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
juvenile dermatomyositis 6 | 1,187
lung adenocarcinoma 6 | 2,716
malignant mesothelioma 6 | 3,232
non-small cell lung cancer 6 | 2,890
primitive neuroectodermal tumor 6 | 3,035
Astrocytoma, Pilocytic 5 | 3,081
Cerebral atrophy 5 | 178
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Epilepsy 5 | 792
Global developmental delay 5 | 608
Intellectual disability 5 | 1,016
Lissencephaly 5 | 69
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Muscle Spasticity 5 | 195
Pachygyria 5 | 41
Poor school performance 5 | 645
Short nose 5 | 132
Small nose 5 | 132
acute quadriplegic myopathy 5 | 1,158
diabetes mellitus 5 | 1,728
oligodendroglioma 5 | 2,850
pancreatic cancer 5 | 2,398
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Abnormal visual evoked potential 4 | 26
Agyria 4 | 15
Anteverted nostril 4 | 191
Autosomal recessive predisposition 4 | 1,442
Hypoplastic mandible condyle 4 | 275
Kidney cancer 4 | 2,613
Mandibular hypoplasia 4 | 275
Microcephaly 4 | 166
Micrognathism 4 | 275
Neurodegenerative disease 4 | 414
Optic Atrophy 4 | 242
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Small head 4 | 374
Waldenstrons macroglobulinemia 4 | 765
adrenocortical carcinoma 4 | 1,428
dermatomyositis 4 | 966
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
tuberculosis and treatment for 6 months 4 | 409
Abnormally small eyeball 3 | 97
Acquired scoliosis 3 | 281
Alzheimer's disease 3 | 658
Amyotrophic lateral sclerosis 3 | 451
Bipolar Disorder 3 | 666
Brachycephaly 3 | 88
Broad cranium shape 3 | 88
Broad flat nasal bridge 3 | 236
Byzanthine arch palate 3 | 194
Congenital Bilateral Cataracts 3 | 50
Congenital cataract 3 | 50
Curvature of spine 3 | 282
Decreased size of eyeball 3 | 97
Hypoplasia of corpus callosum 3 | 90
Large auricle 3 | 87
Large dysplastic ears 3 | 87
Large pinnae 3 | 87
Large prominent ears 3 | 87
Large protruding ears 3 | 87
Large, floppy ears 3 | 87
Macrotia 3 | 87
Nasal bridge wide 3 | 236
Schizophrenia 3 | 1,160
Severe mental retardation (I.Q. 20-34) 3 | 99
Warburg micro syndrome 3 | 18
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
hereditary spastic paraplegia 3 | 318
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung carcinoma 3 | 2,843
pituitary cancer 3 | 1,972

Tissue

Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Blood and immune system 32 | 16,909
Cardiovascular System 32 | 15,192
Nervous System 32 | 16,725
Respiratory system 32 | 16,393

Target Family

Non-IDG 20 | 12,091
Enzyme 13 | 4,145

Reactome Pathway

COPI-independent Golgi-to-ER r... 33 | 33
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytoplasmic dynein 1 light intermediate chain 2 DYNC1LI2 Tbio Non-IDG -0.61455 3.87 95
Ras-related protein Rab-18 RAB18 Tbio Enzyme -1.62447 42.1 103
Cytoplasmic dynein 1 heavy chain 1 DYNC1H1 Tbio Non-IDG -1.80946 62.1 94
Polypeptide N-acetylgalactosaminyltransferase 1 GALNT1 Tbio Enzyme -1.19842 16.7 50
Polypeptide N-acetylgalactosaminyltransferase 2 GALNT2 Tbio Enzyme -1.44267 31.1 106
Cytosolic phospholipase A2 PLA2G4A Tchem Enzyme -2.68316 506.7 274
Ras-related protein Rab-6A RAB6A Tbio Enzyme -2.09488 134.5 207
Platelet-activating factor acetylhydrolase IB subunit beta PAFAH1B2 Tchem Enzyme -0.88890 6.77 191
Protein bicaudal D homolog 1 BICD1 Tbio Non-IDG -1.55047 35.1 49
85/88 kDa calcium-independent phospholipase A2 PLA2G6 Tchem Enzyme -2.50583 353.3 143