Development Level

Tbio 70 | 11,651
Tchem 18 | 1,388
Tclin 8 | 612
Tdark 3 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 5 | 499
abnormal bone structure 2 | 187
decreased circulating choleste... 2 | 93
decreased lean body mass 2 | 135
embryonic lethality prior to t... 2 | 278
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal skin condition 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating free fat... 1 | 31
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small epididymis 1 | 3

Disease

ovarian cancer 64 | 8,520
Carcinoma 50 | 11,493
lung cancer 46 | 4,740
psoriasis 43 | 6,694
osteosarcoma 41 | 7,950
glioblastoma 39 | 5,792
Multiple myeloma 35 | 1,332
Cancer 33 | 2,499
ependymoma 24 | 4,679
malignant mesothelioma 22 | 3,232
medulloblastoma, large-cell 22 | 6,241
subependymal giant cell astrocytoma 22 | 2,287
atypical teratoid / rhabdoid tumor 21 | 5,112
Breast cancer 20 | 3,578
adult high grade glioma 20 | 3,801
dermatomyositis 19 | 966
oligodendroglioma 18 | 2,850
Astrocytoma, Pilocytic 17 | 3,081
Kidney cancer 16 | 2,613
Waldenstrons macroglobulinemia 16 | 765
HIV Infections 15 | 102
tuberculosis 15 | 2,010
astrocytic glioma 14 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
lung carcinoma 14 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
non-small cell lung cancer 13 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Pick disease 12 | 1,894
astrocytoma 12 | 1,146
diabetes mellitus 11 | 1,728
group 4 medulloblastoma 11 | 1,855
group 3 medulloblastoma 10 | 4,104
interstitial cystitis 10 | 2,312
invasive ductal carcinoma 10 | 2,951
pancreatic cancer 10 | 2,398
ulcerative colitis 10 | 1,819
Autosomal recessive predisposition 9 | 1,442
Liver Cirrhosis, Experimental 9 | 769
Rheumatoid arthritis 9 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
lung adenocarcinoma 9 | 2,716
Mantle cell lymphoma 8 | 23
Osteoporosis 8 | 363
non primary Sjogren syndrome sicca 8 | 891
primary Sjogren syndrome 8 | 735
primary pancreatic ductal adenocarcinoma 8 | 1,109
primitive neuroectodermal tumor 8 | 3,035
Arthritis 7 | 290
Asthma 7 | 385
Atopic dermatitis 7 | 952
Immunologic Deficiency Syndromes 7 | 113
Pneumonia 7 | 174
acute myeloid leukemia 7 | 783
cutaneous lupus erythematosus 7 | 1,057
Anemia 6 | 365
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
colon cancer 6 | 1,478
juvenile dermatomyositis 6 | 1,187
Heat Stroke 5 | 13
Infantile onset 5 | 238
Lymphadenopathy 5 | 62
Obesity 5 | 678
Seizures 5 | 596
Splenomegaly 5 | 190
acute quadriplegic myopathy 5 | 1,158
cystic fibrosis 5 | 1,696
Allergic hypersensitivity disease 4 | 126
Brain Ischemia 4 | 110
Colonic Neoplasms 4 | 142
Decreased antibody level in blood 4 | 35
Dermatitis, Atopic 4 | 37
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Elevated hepatic transaminases 4 | 81
Hepatic enzyme increased 4 | 81
Hyperhidrosis disorder 4 | 81
Hypertension 4 | 396
Hypogammaglobulinemia 4 | 35
Inflammatory bowel disease 4 | 151
Liver Dysfunction 4 | 99
Liver cancer 4 | 604
Liver enzymes abnormal 4 | 81
Liver function test increased 4 | 81
Liver function tests abnormal finding 4 | 81
Lung Neoplasms 4 | 232
Lymphopenia 4 | 67
Myocardial Ischemia 4 | 169
Schizophrenia 4 | 1,160
Stomach Neoplasms 4 | 300
Subclinical abnormal liver function tests 4 | 81
Sweating 4 | 81
Transaminases increased 4 | 81
Type 2 diabetes mellitus 4 | 272
esophageal adenocarcinoma 4 | 737
hepatocellular carcinoma 4 | 547
medulloblastoma 4 | 720
pituitary cancer 4 | 1,972
spina bifida 4 | 1,074

Tissue

Endocrine System 98 | 18,159
Blood and immune system 97 | 16,909
Digestive Tract 97 | 17,369
Female tissues 97 | 17,400
Male tissues 97 | 17,142
Nervous System 97 | 16,725
Respiratory system 97 | 16,393
Urinary Tract 97 | 16,678
Cardiovascular System 96 | 15,192
Liver and Pancreas 96 | 16,750
Skin and soft tissues 96 | 17,230

Target Family

Enzyme 48 | 4,145
Non-IDG 31 | 12,091
Kinase 10 | 634
Transcription Factor 7 | 1,400
Ion Channel 3 | 344

Reactome Pathway

CLEC7A (Dectin-1) signaling 99 | 99
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.75887 5.88 183
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Apoptosis-associated speck-like protein containing a CARD PYCARD Tbio Non-IDG -1.86744 55.9 477
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765