Development Level

Tbio 52 | 10,625
Tchem 36 | 1,890
Tclin 8 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 633
decreased lean body mass 4 | 195
abnormal cornea morphology 2 | 24
abnormal lens morphology 2 | 73
decreased circulating choleste... 2 | 85
embryonic lethality prior to t... 2 | 187
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin condition 1 | 6
cardiovascular system phenotyp... 1 | 35
decreased B cell number 1 | 30
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating free fat... 1 | 39
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased macrophage cell numb... 1 | 4
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased thermal nociceptive ... 1 | 4
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased fasted circulating g... 1 | 68
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased startle reflex 1 | 38
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
small epididymis 1 | 3

Disease

ovarian cancer 64 | 8,491
lung cancer 44 | 4,473
psoriasis 43 | 6,685
osteosarcoma 42 | 7,933
glioblastoma 39 | 5,572
Multiple myeloma 34 | 1,327
Cancer 33 | 2,346
medulloblastoma, large-cell 23 | 6,234
atypical teratoid / rhabdoid tumor 22 | 4,369
malignant mesothelioma 22 | 3,163
subependymal giant cell astrocytoma 22 | 2,287
dermatomyositis 18 | 966
oligodendroglioma 18 | 2,849
Breast cancer 17 | 3,098
pilocytic astrocytoma 17 | 3,086
ependymoma 16 | 2,514
Waldenstrons macroglobulinemia 15 | 764
HIV Infections 14 | 99
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
lung carcinoma 14 | 2,844
astrocytic glioma 13 | 2,241
astrocytoma 13 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
tuberculosis 13 | 1,563
ulcerative colitis 13 | 2,087
Pick disease 12 | 1,893
non-small cell lung cancer 12 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
diabetes mellitus 11 | 1,663
pediatric high grade glioma 11 | 2,712
Carcinoma 10 | 2,147
adult high grade glioma 10 | 2,148
group 4 medulloblastoma 10 | 1,875
interstitial cystitis 10 | 2,299
invasive ductal carcinoma 10 | 2,950
lung adenocarcinoma 10 | 2,714
pancreatic cancer 10 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
medulloblastoma 9 | 1,524
primary pancreatic ductal adenocarcinoma 9 | 1,271
primitive neuroectodermal tumor 9 | 3,031
Mantle cell lymphoma 8 | 20
Rheumatoid Arthritis 8 | 1,170
non primary Sjogren syndrome sicca 8 | 840
Arthritis 7 | 248
acute myeloid leukemia 7 | 785
cutaneous lupus erythematosus 7 | 1,056
posterior fossa group A ependymoma 7 | 1,511
primary Sjogren syndrome 7 | 788
Atopic dermatitis 6 | 944
Obesity 6 | 616
Osteoporosis 6 | 259
acute quadriplegic myopathy 6 | 1,157
colon cancer 6 | 1,475
juvenile dermatomyositis 6 | 1,189
Asthma 5 | 349
Heat Stroke 5 | 12
IGA Glomerulonephritis 5 | 454
Mammary Neoplasms 5 | 410
cystic fibrosis 5 | 1,670
Adenocarcinoma 4 | 115
Allergic hypersensitivity disease 4 | 123
Brain Ischemia 4 | 87
Cherubism 4 | 14
Colonic Neoplasms 4 | 126
Common variable immunodeficiency 4 | 98
Dermatitis, Atopic 4 | 45
Diabetes Mellitus, Non-Insulin-Dependent 4 | 161
Inflammatory bowel disease 4 | 142
Lung Neoplasms 4 | 171
Myocardial Ischemia 4 | 169
Osteopetrosis 4 | 40
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 832
group 3 medulloblastoma 4 | 2,254
hepatocellular carcinoma 4 | 550
pituitary cancer 4 | 1,972
sonic hedgehog group medulloblastoma 4 | 1,482
spina bifida 4 | 1,064
tuberculosis and treatment for 6 months 4 | 686
Alzheimer's disease 3 | 644
Colitis 3 | 46
Contact Dermatitis 3 | 80
Crohn's disease 3 | 304
Eosinophilia 3 | 65
Liver carcinoma 3 | 217
Lymphoma 3 | 57
Multiple Sclerosis 3 | 498
Parkinson's disease 3 | 364
Peripheral Neuropathy 3 | 303
Prostatic Neoplasms 3 | 471
Reperfusion Injury 3 | 84
Schizophrenia 3 | 503
Stomach Neoplasms 3 | 282
Vascular disease 3 | 281
active Crohn's disease 3 | 918
aldosterone-producing adenoma 3 | 664
ductal carcinoma in situ 3 | 1,745
progressive supranuclear palsy 3 | 674
sarcoidosis 3 | 368

Tissue

Blood and immune system 97 | 17,994
Digestive Tract 97 | 18,472
Endocrine System 97 | 18,511
Female tissues 97 | 18,646
Liver and Pancreas 97 | 18,135
Male tissues 97 | 17,968
Nervous System 97 | 18,560
Urinary Tract 97 | 18,443
Cardiovascular System 96 | 17,957
Respiratory system 96 | 17,483
Skin and soft tissues 95 | 18,114

Target Family

Enzyme 48 | 4,146
Non-IDG 29 | 11,969
Kinase 10 | 634
Transcription Factor 7 | 1,400
Ion Channel 3 | 341

Reactome Pathway

CLEC7A (Dectin-1) signaling 97 | 97
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.39396 233.2 634
Caspase recruitment domain-containing protein 11 CARD11 Tbio Enzyme -2.12968 129.2 231
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.87718 69.0 145
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
Apoptosis-associated speck-like protein containing a CARD PYCARD Tbio Non-IDG -1.81555 50.5 390
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.54884 305.8 337
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.41371 28.0 678
Calcineurin subunit B type 1 PPP3R1 Tbio Non-IDG -2.56314 362.9 113
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.25781 180.0 594
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.21151 15.4 162