Development Level

Tbio 52 | 10,625
Tchem 37 | 1,890
Tclin 8 | 602
Tdark 1 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 6 | 633
decreased lean body mass 4 | 195
abnormal cornea morphology 2 | 24
abnormal lens morphology 2 | 73
decreased circulating choleste... 2 | 85
embryonic lethality prior to t... 2 | 187
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin condition 1 | 6
cardiovascular system phenotyp... 1 | 35
decreased B cell number 1 | 30
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating free fat... 1 | 39
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased macrophage cell numb... 1 | 4
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased thermal nociceptive ... 1 | 4
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased fasted circulating g... 1 | 68
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased startle reflex 1 | 38
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
small epididymis 1 | 3

Disease

ovarian cancer 65 | 8,484
lung cancer 44 | 4,466
psoriasis 43 | 6,685
osteosarcoma 42 | 7,933
glioblastoma 39 | 5,572
Multiple myeloma 35 | 1,327
Cancer 33 | 2,346
medulloblastoma, large-cell 23 | 6,234
atypical teratoid / rhabdoid tumor 22 | 4,369
subependymal giant cell astrocytoma 22 | 2,287
malignant mesothelioma 21 | 3,162
dermatomyositis 19 | 933
Breast cancer 18 | 3,094
oligodendroglioma 18 | 2,849
pilocytic astrocytoma 17 | 3,086
Waldenstrons macroglobulinemia 16 | 765
ependymoma 16 | 2,514
HIV Infections 15 | 100
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
lung carcinoma 14 | 2,844
astrocytic glioma 13 | 2,241
astrocytoma 13 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
tuberculosis 13 | 1,557
ulcerative colitis 13 | 2,087
Pick disease 12 | 1,893
non-small cell lung cancer 12 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
diabetes mellitus 11 | 1,663
pediatric high grade glioma 11 | 2,712
Carcinoma 10 | 2,147
adult high grade glioma 10 | 2,148
group 4 medulloblastoma 10 | 1,875
interstitial cystitis 10 | 2,299
invasive ductal carcinoma 10 | 2,950
lung adenocarcinoma 10 | 2,713
pancreatic cancer 10 | 2,300
Rheumatoid Arthritis 9 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
medulloblastoma 9 | 1,524
primary pancreatic ductal adenocarcinoma 9 | 1,271
primitive neuroectodermal tumor 9 | 3,031
Mantle cell lymphoma 8 | 18
non primary Sjogren syndrome sicca 8 | 840
primary Sjogren syndrome 8 | 789
Arthritis 7 | 248
acute myeloid leukemia 7 | 780
cutaneous lupus erythematosus 7 | 1,056
posterior fossa group A ependymoma 7 | 1,511
Atopic dermatitis 6 | 944
Obesity 6 | 616
Osteoporosis 6 | 257
acute quadriplegic myopathy 6 | 1,157
colon cancer 6 | 1,475
juvenile dermatomyositis 6 | 1,189
Asthma 5 | 349
Heat Stroke 5 | 12
IGA Glomerulonephritis 5 | 454
Mammary Neoplasms 5 | 410
cystic fibrosis 5 | 1,665
Adenocarcinoma 4 | 115
Allergic hypersensitivity disease 4 | 123
Brain Ischemia 4 | 87
Cherubism 4 | 14
Colonic Neoplasms 4 | 126
Dermatitis, Atopic 4 | 45
Diabetes Mellitus, Non-Insulin-Dependent 4 | 157
Inflammatory bowel disease 4 | 142
Lung Neoplasms 4 | 171
Myocardial Ischemia 4 | 169
Osteopetrosis 4 | 40
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 832
group 3 medulloblastoma 4 | 2,254
pituitary cancer 4 | 1,972
sonic hedgehog group medulloblastoma 4 | 1,482
spina bifida 4 | 1,064
tuberculosis and treatment for 6 months 4 | 686
Alzheimer's disease 3 | 644
Colitis 3 | 46
Contact Dermatitis 3 | 80
Crohn's disease 3 | 304
Eosinophilia 3 | 65
Gaucher disease type 3 3 | 76
Liver carcinoma 3 | 217
Lymphoma 3 | 56
Multiple Sclerosis 3 | 498
Parkinson's disease 3 | 364
Peripheral Neuropathy 3 | 303
Prostatic Neoplasms 3 | 471
Reperfusion Injury 3 | 84
Schizophrenia 3 | 501
Stomach Neoplasms 3 | 282
Vascular disease 3 | 281
active Crohn's disease 3 | 918
aldosterone-producing adenoma 3 | 664
ductal carcinoma in situ 3 | 1,745
hepatocellular carcinoma 3 | 532
progressive supranuclear palsy 3 | 674
sarcoidosis 3 | 358

Tissue

Blood and immune system 98 | 17,995
Digestive Tract 98 | 18,473
Endocrine System 98 | 18,512
Female tissues 98 | 18,647
Liver and Pancreas 98 | 18,136
Male tissues 98 | 17,969
Nervous System 98 | 18,561
Urinary Tract 98 | 18,444
Cardiovascular System 97 | 17,958
Respiratory system 97 | 17,484
Skin and soft tissues 96 | 18,115

Target Family

Enzyme 49 | 4,146
Non-IDG 29 | 11,971
Kinase 10 | 634
Transcription Factor 7 | 1,400
Ion Channel 3 | 341

Reactome Pathway

CLEC7A (Dectin-1) signaling 98 | 98
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.08055 124.6 194
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.83055 69.0 145
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34160 1960.9 1181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.24871 191.5 579
Ubiquitin-conjugating enzyme E2 D2 UBE2D2 Tbio Non-IDG -2.06903 107.6 211