Development Level

Tchem 6 | 1,890
Tbio 4 | 10,625

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
decreased circulating HDL chol... 1 | 77
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating magnesiu... 1 | 11
decreased eosinophil cell numb... 1 | 41
decreased lean body mass 1 | 195
decreased macrophage cell numb... 1 | 4
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased mean platelet volume 1 | 19
increased startle reflex 1 | 38
preweaning lethality, complete... 1 | 633
small epididymis 1 | 3

Disease

ovarian cancer 8 | 8,484
subependymal giant cell astrocytoma 8 | 2,287
medulloblastoma, large-cell 7 | 6,234
atypical teratoid / rhabdoid tumor 6 | 4,369
glioblastoma 6 | 5,572
pilocytic astrocytoma 6 | 3,086
Breast cancer 5 | 3,094
Carcinoma 5 | 2,147
lung cancer 5 | 4,466
malignant mesothelioma 5 | 3,162
osteosarcoma 5 | 7,933
primitive neuroectodermal tumor 5 | 3,031
psoriasis 5 | 6,685
Cancer 4 | 2,346
Pick disease 4 | 1,893
adult high grade glioma 4 | 2,148
astrocytic glioma 4 | 2,241
ependymoma 4 | 2,514
group 4 medulloblastoma 4 | 1,875
lung adenocarcinoma 4 | 2,713
oligodendroglioma 4 | 2,849
ulcerative colitis 4 | 2,087
Obesity 3 | 616
Rheumatoid Arthritis 3 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
medulloblastoma 3 | 1,524
sonic hedgehog group medulloblastoma 3 | 1,482
Brain Hypoxia 2 | 2
Hepatolenticular Degeneration 2 | 24
Left Ventricular Hypertrophy 2 | 24
Prostatic Neoplasms 2 | 471
Waldenstrons macroglobulinemia 2 | 765
astrocytoma 2 | 1,493
colon cancer 2 | 1,475
cystic fibrosis 2 | 1,665
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
lung carcinoma 2 | 2,844
non-small cell lung cancer 2 | 2,798
pancreatic cancer 2 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pituitary cancer 2 | 1,972
spina bifida 2 | 1,064
Arthritis 1 | 248
Atopic dermatitis 1 | 944
Autistic Disorder 1 | 320
Autosomal dominant cerebellar ataxia 1 | 34
Barrett's esophagus 1 | 183
Breast abscess 1 | 5
Cardiomegaly 1 | 66
Cerebellar Ataxia 1 | 72
Cherubism 1 | 14
Chronic Lymphocytic Leukemia 1 | 242
Cornea plana 1 | 12
Corneal disease 1 | 32
Diabetes Mellitus, Insulin-Dependent 1 | 76
Down syndrome 1 | 548
Exocrine pancreatic insufficiency 1 | 21
Gaucher disease type 3 1 | 76
Graves Disease 1 | 17
Keratoconjunctivitis sicca 1 | 19
Kidney cancer 1 | 118
Lobular neoplasia 1 | 15
Malignant neoplasm of breast 1 | 63
Mastitis 1 | 48
Motor neuron disease 1 | 39
Myocardial Ischemia 1 | 169
Neurodegenerative disease 1 | 383
Osteomyelitis 1 | 20
Osteopetrosis 1 | 40
Osteoporosis 1 | 257
Pancreatitis 1 | 97
Peripheral Neuropathy 1 | 303
Pneumothorax 1 | 17
Prevention of Cardiac Transplant Rejection 1 | 14
Prevention of Kidney Transplant Rejection 1 | 16
Prevention of Liver Transplant Rejection 1 | 14
Progressive multifocal leukoencephalopathy 1 | 24
Schizophrenia 1 | 501
Septic arthritis 1 | 8
Severe Recalcitrant Psoriasis 1 | 11
Tear film insufficiency 1 | 14
Thyrotoxicosis 1 | 38
Toxic shock syndrome 1 | 28
Transplanted organ rejection 1 | 10
Type 1 diabetes mellitus 1 | 101
acute quadriplegic myopathy 1 | 1,157
aldosterone-producing adenoma 1 | 664
esophageal adenocarcinoma 1 | 737
gastric carcinoma 1 | 832
hereditary spastic paraplegia 1 | 313
interstitial lung disease 1 | 291
nervous system disorder 1 | 53
pediatric high grade glioma 1 | 2,712
posterior fossa group A ependymoma 1 | 1,511
primary pancreatic ductal adenocarcinoma 1 | 1,271
severe Alzheimer's disease 1 | 49
tuberculosis 1 | 1,557
tuberculosis and treatment for 6 months 1 | 686

Tissue

Blood and immune system 10 | 17,995
Cardiovascular System 10 | 17,958
Digestive Tract 10 | 18,473
Endocrine System 10 | 18,512
Female tissues 10 | 18,647
Liver and Pancreas 10 | 18,136
Male tissues 10 | 17,969
Nervous System 10 | 18,561
Respiratory system 10 | 17,484
Skin and soft tissues 10 | 18,115
Urinary Tract 10 | 18,444

Target Family

Enzyme 3 | 4,146
Ion Channel 3 | 341
Transcription Factor 3 | 1,400
Non-IDG 1 | 11,971

Reactome Pathway

CLEC7A (Dectin-1) induces NFAT... 10 | 10
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA Tchem Enzyme -2.95943 932.4 290
Nuclear factor of activated T-cells, cytoplasmic 3 NFATC3 Tbio Transcription Factor -1.99681 101.3 183
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.51391 26.9 123
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.35408 241.6 357
Calcineurin subunit B type 1 PPP3R1 Tbio Non-IDG -2.53639 362.9 113
Inositol 1,4,5-trisphosphate receptor type 3 ITPR3 Tchem Ion Channel -2.49510 301.4 127
Inositol 1,4,5-trisphosphate receptor type 2 ITPR2 Tchem Ion Channel -1.87460 72.5 86
Inositol 1,4,5-trisphosphate receptor type 1 ITPR1 Tchem Ion Channel -2.72307 534.1 222
Nuclear factor of activated T-cells, cytoplasmic 1 NFATC1 Tchem Transcription Factor -2.67800 471.3 344