Development Level

Tbio 20 | 11,445
Tchem 6 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
abnormal retina morphology 2 | 71
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal incisor color 1 | 3
abnormal startle reflex 1 | 15
abnormal tibia morphology 1 | 14
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
short tibia 1 | 97

Disease

Carcinoma 23 | 11,493
atypical teratoid / rhabdoid tumor 19 | 5,112
glioblastoma 17 | 5,792
ovarian cancer 16 | 8,520
medulloblastoma, large-cell 15 | 6,241
Cancer 13 | 2,499
ependymoma 13 | 4,679
osteosarcoma 13 | 7,950
psoriasis 13 | 6,694
adult high grade glioma 12 | 3,801
lung cancer 11 | 4,740
oligodendroglioma 11 | 2,850
primitive neuroectodermal tumor 11 | 3,035
Kidney cancer 10 | 2,613
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
astrocytic glioma 8 | 2,597
Astrocytoma, Pilocytic 7 | 3,081
Breast cancer 7 | 3,578
invasive ductal carcinoma 7 | 2,951
malignant mesothelioma 7 | 3,232
subependymal giant cell astrocytoma 7 | 2,287
Intellectual disability 6 | 1,016
acute quadriplegic myopathy 6 | 1,158
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Parkinson's disease 5 | 392
Schizophrenia 5 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
medulloblastoma 5 | 720
pancreatic cancer 5 | 2,398
Alzheimer's disease 4 | 658
Myopathy 4 | 185
Osteoporosis 4 | 363
Pick disease 4 | 1,894
colon cancer 4 | 1,478
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
gastric cancer 4 | 459
gastric carcinoma 4 | 807
group 4 medulloblastoma 4 | 1,855
non-small cell lung cancer 4 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
tuberculosis 4 | 2,010
Bipolar Disorder 3 | 666
Gastrointestinal Stromal Tumors 3 | 48
Hypoplasia of corpus callosum 3 | 90
Liver cancer 3 | 604
Liver neoplasms 3 | 130
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
Rheumatoid arthritis 3 | 1,191
Skeletal muscle neoplasm 3 | 8
Small head 3 | 374
Stomach Neoplasms 3 | 300
Strabismus 3 | 270
Vascular disease 3 | 319
Waldenstrons macroglobulinemia 3 | 765
adrenocortical carcinoma 3 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
juvenile dermatomyositis 3 | 1,187
posterior fossa group A ependymoma 3 | 468
sonic hedgehog group medulloblastoma 3 | 467
ulcerative colitis 3 | 1,819
Arthritis 2 | 290
Colonic Neoplasms 2 | 142
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Disease Progression 2 | 136
Down syndrome 2 | 499
Duchenne muscular dystrophy 2 | 601
Endometrial cancer 2 | 311
Endometriosis 2 | 540
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Heart disease 2 | 306
Lung Neoplasms 2 | 232
Lung disease 2 | 142
Myocardial Ischemia 2 | 169
Neoplasm Invasiveness 2 | 161
Neurodevelopmental Disorders 2 | 70
Pediatric failure to thrive 2 | 365
Polycystic ovary syndrome 2 | 360
Psychotic Disorders 2 | 151
Seizures 2 | 596
Status Epilepticus 2 | 98
Upward slant of palpebral fissure 2 | 75
acute myeloid leukemia 2 | 783
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
hepatocellular carcinoma 2 | 547
nephrosclerosis 2 | 333
pancreatic carcinoma 2 | 562
primary pancreatic ductal adenocarcinoma 2 | 1,109

Tissue

Skin and soft tissues 26 | 17,230
Digestive Tract 25 | 17,369
Male tissues 25 | 17,142
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Blood and immune system 23 | 16,909
Nervous System 23 | 16,725
Liver and Pancreas 21 | 16,750
Respiratory system 21 | 16,393
Urinary Tract 20 | 16,678
Cardiovascular System 19 | 15,192

Target Family

Non-IDG 11 | 12,091
Transcription Factor 10 | 1,400
Kinase 4 | 634
Enzyme 2 | 4,145

Reactome Pathway

CDO in myogenesis 27 | 27
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.80290 601.6 434
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 BNIP2 Tbio Non-IDG -1.54058 32.8 232
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Cadherin-2 CDH2 Tbio Non-IDG -3.19431 1382.9 993
Cadherin-15 CDH15 Tbio Non-IDG -1.56203 34.3 212
Cadherin-4 CDH4 Tbio Non-IDG -1.95165 92.7 193
Transcription factor 12 TCF12 Tbio Transcription Factor -2.24606 159.8 253
C-Jun-amino-terminal kinase-interacting protein 4 SPAG9 Tbio Enzyme -2.45490 258.6 149
Netrin-3 NTN3 Tdark Non-IDG -0.56638 4.07 82
Mitogen-activated protein kinase 12 MAPK12 Tchem Kinase -1.95173 88.4 378