Development Level

Tbio 57 | 11,651
Tchem 5 | 1,388
Tclin 5 | 612
Tdark 5 | 6,593

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal embryo size 4 | 220
embryonic growth retardation 3 | 106
abnormal heart morphology 2 | 162
abnormal placenta size 2 | 20
anophthalmia 2 | 33
embryonic lethality prior to t... 2 | 278
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal forebrain morphology 1 | 10
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal placenta morphology 1 | 5
abnormal skin coloration 1 | 25
brachydactyly 1 | 19
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
increased circulating alanine ... 1 | 13
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
pallor 1 | 34
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
syndactyly 1 | 23

Disease

ovarian cancer 51 | 8,520
lung cancer 32 | 4,740
psoriasis 32 | 6,694
Carcinoma 29 | 11,493
osteosarcoma 29 | 7,950
Multiple myeloma 27 | 1,332
glioblastoma 23 | 5,792
HIV Infections 15 | 102
medulloblastoma, large-cell 15 | 6,241
Breast cancer 14 | 3,578
Cancer 14 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
malignant mesothelioma 13 | 3,232
non-small cell lung cancer 13 | 2,890
atypical teratoid / rhabdoid tumor 12 | 5,112
ependymoma 12 | 4,679
dermatomyositis 11 | 966
group 3 medulloblastoma 11 | 4,104
Waldenstrons macroglobulinemia 10 | 765
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
invasive ductal carcinoma 9 | 2,951
lung adenocarcinoma 9 | 2,716
Pick disease 8 | 1,894
adrenocortical carcinoma 8 | 1,428
adult high grade glioma 8 | 3,801
non primary Sjogren syndrome sicca 8 | 891
active Crohn's disease 7 | 922
astrocytoma 7 | 1,146
diabetes mellitus 7 | 1,728
oligodendroglioma 7 | 2,850
pancreatic cancer 7 | 2,398
astrocytic glioma 6 | 2,597
subependymal giant cell astrocytoma 6 | 2,287
Astrocytoma, Pilocytic 5 | 3,081
Liver Cirrhosis, Experimental 5 | 769
Mantle cell lymphoma 5 | 23
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
lung carcinoma 5 | 2,843
primary Sjogren syndrome 5 | 735
primitive neuroectodermal tumor 5 | 3,035
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Atopic dermatitis 4 | 952
Endometriosis 4 | 540
Osteoporosis 4 | 363
acute quadriplegic myopathy 4 | 1,158
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
juvenile dermatomyositis 4 | 1,187
progressive supranuclear palsy 4 | 676
Anemia 3 | 365
Kidney cancer 3 | 2,613
Polycystic ovary syndrome 3 | 360
acute myeloid leukemia 3 | 783
ductal carcinoma in situ 3 | 1,745
esophageal adenocarcinoma 3 | 737
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
medulloblastoma 3 | 720
nasopharyngeal carcinoma 3 | 1,058
primary pancreatic ductal adenocarcinoma 3 | 1,109
Acquired metabolic disease 2 | 336
Alzheimer's disease 2 | 658
Animal Mammary Neoplasms 2 | 136
Autosomal recessive predisposition 2 | 1,442
Bladder Neoplasm 2 | 112
Breast Neoplasms 2 | 445
Carcinoma, Hepatocellular 2 | 228
Congestive heart failure 2 | 113
Duchenne muscular dystrophy 2 | 601
Esophageal Squamous Cell Carcinoma 2 | 77
Failure to gain weight 2 | 365
Hypoplastic mandible condyle 2 | 275
Intellectual disability 2 | 1,016
Liver carcinoma 2 | 240
Mammary Neoplasms 2 | 425
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Mandibular hypoplasia 2 | 275
Micrognathism 2 | 275
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Pediatric failure to thrive 2 | 365
Pick's disease 2 | 15
Rheumatoid arthritis 2 | 1,191
Squamous cell carcinoma of esophagus 2 | 77
Urinary Bladder Neoplasms 2 | 114
chronic kidney disease 2 | 90
cystic fibrosis 2 | 1,696
hepatocellular carcinoma 2 | 547
sarcoidosis 2 | 370
sonic hedgehog group medulloblastoma 2 | 467
Carcinoma, squamous cell of head and neck 1 | 31
Conjunctivitis 1 | 53
Full lower lip 1 | 64
JMP syndrome 1 | 2
Prominent lower lip 1 | 64
Waterhouse-Friderichsen syndrome 1 | 11

Tissue

Endocrine System 71 | 18,159
Blood and immune system 70 | 16,909
Digestive Tract 70 | 17,369
Female tissues 70 | 17,400
Male tissues 70 | 17,142
Nervous System 70 | 16,725
Respiratory system 70 | 16,393
Urinary Tract 70 | 16,678
Cardiovascular System 69 | 15,192
Liver and Pancreas 69 | 16,750
Skin and soft tissues 69 | 17,230

Target Family

Enzyme 48 | 4,145
Non-IDG 23 | 12,091
Kinase 1 | 634

Reactome Pathway

CDK-mediated phosphorylation a... 72 | 72
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
Anaphase-promoting complex subunit 5 ANAPC5 Tbio Enzyme -1.45912 28.7 251
Cell division control protein 6 homolog CDC6 Tbio Non-IDG -2.51683 336.8 574
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tbio Enzyme -1.09295 11.9 110
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.22269 15.9 168
Fizzy-related protein homolog FZR1 Tbio Non-IDG -1.78590 63.2 228
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.87037 83.7 245
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
26S proteasome regulatory subunit 8 PSMC5 Tbio Enzyme -1.70989 52.2 200
26S proteasome regulatory subunit 4 PSMC1 Tbio Enzyme -1.15617 13.5 118