Development Level

Tbio 28 | 10,625
Tchem 16 | 1,890
Tclin 5 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 2 | 633
decreased body length 1 | 108

Disease

ovarian cancer 37 | 8,492
Multiple myeloma 26 | 1,328
lung cancer 24 | 4,473
psoriasis 22 | 6,685
osteosarcoma 18 | 7,933
glioblastoma 16 | 5,572
HIV Infections 15 | 100
dermatomyositis 10 | 967
Cancer 9 | 2,346
Waldenstrons macroglobulinemia 9 | 765
malignant mesothelioma 9 | 3,163
Breast cancer 8 | 3,099
medulloblastoma, large-cell 8 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
astrocytoma 6 | 1,493
non-small cell lung cancer 6 | 2,798
Mantle cell lymphoma 5 | 20
atypical teratoid / rhabdoid tumor 5 | 4,369
diabetes mellitus 5 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
invasive ductal carcinoma 5 | 2,950
non primary Sjogren syndrome sicca 5 | 840
pancreatic cancer 5 | 2,300
pediatric high grade glioma 5 | 2,712
Pick disease 4 | 1,893
group 3 medulloblastoma 4 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
lung adenocarcinoma 4 | 2,714
lung carcinoma 4 | 2,844
oligodendroglioma 4 | 2,849
pilocytic astrocytoma 4 | 3,086
posterior fossa group A ependymoma 4 | 1,511
primary Sjogren syndrome 4 | 789
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 2,087
Peripheral Neuropathy 3 | 303
active Crohn's disease 3 | 918
acute myeloid leukemia 3 | 785
astrocytic glioma 3 | 2,241
ependymoma 3 | 2,514
juvenile dermatomyositis 3 | 1,189
primary pancreatic ductal adenocarcinoma 3 | 1,271
progressive supranuclear palsy 3 | 674
tuberculosis 3 | 1,563
Alzheimer's disease 2 | 644
Animal Mammary Neoplasms 2 | 136
IGA Glomerulonephritis 2 | 454
Mammary Neoplasms, Experimental 2 | 150
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Osteoporosis 2 | 259
Pick's disease 2 | 14
Polycystic Ovary Syndrome 2 | 335
Squamous cell carcinoma of esophagus 2 | 82
adrenocortical carcinoma 2 | 1,427
atypical teratoid/rhabdoid tumor 2 | 1,095
chronic kidney disease 2 | 90
colon cancer 2 | 1,475
cutaneous lupus erythematosus 2 | 1,056
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 550
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299
medulloblastoma 2 | 1,524
primitive neuroectodermal tumor 2 | 3,031
tuberculosis and treatment for 6 months 2 | 686
Acquired metabolic disease 1 | 267
Anemia 1 | 252
Ankylosing spondylitis 1 | 138
Atopic dermatitis 1 | 944
Barrett's esophagus 1 | 185
Bladder Neoplasm 1 | 109
COPD 1 | 116
Carpal tunnel syndrome 1 | 19
Cockayne syndrome 1 | 54
Contact Dermatitis 1 | 80
Crohn Disease 1 | 97
Degenerative polyarthritis 1 | 93
Diabetes Mellitus, Non-Insulin-Dependent 1 | 161
Endometriosis 1 | 535
Hypertensive retinopathy 1 | 9
Kidney Diseases 1 | 86
Liver neoplasms 1 | 109
Meier-Gorlin syndrome 1 | 12
Melanoma 1 | 261
Myocardial Ischemia 1 | 169
Parkinson's disease 1 | 364
Patau syndrome 1 | 15
Seckel syndrome 1 | 35
Vascular disease 1 | 281
acute quadriplegic myopathy 1 | 1,157
breast carcinoma 1 | 1,614
cystic fibrosis 1 | 1,670
hand, foot and mouth disease 1 | 11
nasopharyngeal carcinoma 1 | 1,056
pituitary cancer 1 | 1,972
sarcoidosis 1 | 368
sonic hedgehog group medulloblastoma 1 | 1,482
substance-related disorder 1 | 105

Tissue

Blood and immune system 50 | 17,995
Digestive Tract 50 | 18,473
Endocrine System 50 | 18,512
Female tissues 50 | 18,647
Liver and Pancreas 50 | 18,136
Male tissues 50 | 17,969
Nervous System 50 | 18,561
Urinary Tract 50 | 18,444
Cardiovascular System 49 | 17,958
Respiratory system 49 | 17,484
Skin and soft tissues 49 | 18,115

Target Family

Enzyme 39 | 4,146
Non-IDG 10 | 11,969
Kinase 1 | 634

Reactome Pathway

CDK-mediated phosphorylation a... 50 | 50
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division control protein 6 homolog CDC6 Tchem Non-IDG -2.49821 321.6 473
Polyubiquitin-C UBC Tbio Non-IDG -2.87696 56.7 130
Polyubiquitin-B UBB Tbio Non-IDG -1.96206 92.3 370
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.86105 71.4 158
26S protease regulatory subunit 6A PSMC3 Tbio Enzyme -1.26468 18.5 271
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.44048 25.4 280
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.59489 39.3 30
26S protease regulatory subunit 8 PSMC5 Tbio Enzyme -1.68986 49.6 167
26S protease regulatory subunit 4 PSMC1 Tbio Enzyme -1.14594 12.7 118
26S protease regulatory subunit 10B PSMC6 Tchem Enzyme -2.64775 334.8 203