Development Level

Tbio 10 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased caudal vertebrae num... 1 | 53
embryonic lethality prior to o... 1 | 239
prenatal lethality prior to he... 1 | 87

Disease

group 3 medulloblastoma 7 | 4,104
Carcinoma 6 | 11,493
osteosarcoma 6 | 7,950
ovarian cancer 6 | 8,520
Breast cancer 5 | 3,578
glioblastoma 5 | 5,792
lung cancer 5 | 4,740
medulloblastoma, large-cell 5 | 6,241
psoriasis 5 | 6,694
Meier-Gorlin syndrome 4 | 10
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
Autosomal recessive predisposition 3 | 1,442
Birth length less than 3rd percentile 3 | 6
Cancer 3 | 2,499
Congenital hypoplasia of breast 3 | 25
Congenital small ears 3 | 48
Delayed bone age 3 | 136
EAR, PATELLA, SHORT STATURE SYNDROME 3 | 7
Failure to gain weight 3 | 365
Fetal Growth Retardation 3 | 189
Hypertrophy of clitoris 3 | 40
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Isolated growth hormone deficiency 3 | 30
Microcephaly 3 | 166
Microstomia 3 | 78
Pediatric failure to thrive 3 | 365
Seckel syndrome 3 | 34
Slender, gracile long tubular bones 3 | 21
Small head 3 | 374
adrenocortical carcinoma 3 | 1,428
atypical teratoid / rhabdoid tumor 3 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
primitive neuroectodermal tumor 3 | 3,035
Absent bone maturation in sternum 2 | 4
Absent sternal ossification 2 | 4
Atopic dermatitis 2 | 952
Cryptorchidism 2 | 296
Decreased projection of maxilla 2 | 66
Deficiency of upper jaw bones 2 | 66
Feeding difficulties 2 | 127
Full lower lip 2 | 64
Gastroesophageal reflux disease 2 | 110
Genu varum 2 | 29
Heartburn 2 | 78
Hypoplasia of the maxilla 2 | 66
Hypoplastic mandible condyle 2 | 275
Hypotrophic maxilla 2 | 66
Mandibular hypoplasia 2 | 275
Maxillary retrognathia 2 | 66
Micrognathism 2 | 275
Patella aplasia-hypoplasia 2 | 12
Prominent lower lip 2 | 64
Pulmonary emphysema 2 | 48
Retrusion of upper jaw bones 2 | 66
Short ribs 2 | 30
Small labia majora 2 | 16
colon cancer 2 | 1,478
dermatomyositis 2 | 966
ductal carcinoma in situ 2 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
invasive ductal carcinoma 2 | 2,951
nasopharyngeal carcinoma 2 | 1,058
pediatric high grade glioma 2 | 1,064
Abnormality of pelvic girdle bone morphology 1 | 37
Absent external auditory canals 1 | 23
Atresia of the external auditory canal 1 | 23
Atretic auditory canal 1 | 23
Blepharophimosis 1 | 70
Breast Neoplasms 1 | 445
Congenital clubfoot 1 | 109
Congenital deafness 1 | 185
Deafness 1 | 198
Dwarfism 1 | 37
Dyspnea 1 | 76
Frontal bossing 1 | 157
Gout 1 | 106
Hearing Loss, Partial 1 | 185
Long eyelashes 1 | 37
Long narrow head 1 | 75
Low Birth Weights 1 | 69
Mammary Neoplasms 1 | 425
Microretrognathia 1 | 13
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Narrow thorax 1 | 53
Overcurvature of nail 1 | 6
Range of joint movement increased 1 | 32
Respiratory distress 1 | 43
Short palpebral fissure 1 | 38
Small for gestational age (disorder) 1 | 69
Thin rib 1 | 21
Thin skin 1 | 47
Tracheomalacia 1 | 22
Triangular face 1 | 58
Turridolichocephaly 1 | 75
hearing impairment 1 | 199

Tissue

Blood and immune system 10 | 16,909
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678
Cardiovascular System 9 | 15,192

Target Family

Non-IDG 6 | 12,091
Transcription Factor 3 | 1,400
Enzyme 1 | 4,145

Reactome Pathway

CDC6 association with the ORC:... 10 | 10
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 28.0 148
Origin recognition complex subunit 2 ORC2 Tbio Non-IDG -0.68275 4.92 168
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50983 31.3 71
Transcription factor E2F2 E2F2 Tbio Transcription Factor -2.10245 108.0 267
Origin recognition complex subunit 3 ORC3 Tbio Non-IDG -1.25409 17.4 192
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.38268 26.3 165
DNA helicase MCM8 MCM8 Tbio Enzyme -1.42239 28.6 195
Origin recognition complex subunit 4 ORC4 Tbio Non-IDG -1.52127 33.7 155
Transcription factor E2F3 E2F3 Tbio Transcription Factor -2.27005 133.3 259
Transcription factor E2F1 E2F1 Tbio Transcription Factor -2.31412 201.4 1086