Development Level

Tchem 6 | 1,598
Tclin 4 | 613
Tbio 1 | 11,445

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal retina morphology 1 | 71
decreased bone mineral content 1 | 151
decreased circulating serum al... 1 | 82
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
short tibia 1 | 97

Disease

Carcinoma 10 | 11,493
Cancer 8 | 2,499
ovarian cancer 8 | 8,520
osteosarcoma 7 | 7,950
Astrocytoma, Pilocytic 6 | 3,081
glioblastoma 6 | 5,792
invasive ductal carcinoma 6 | 2,951
medulloblastoma, large-cell 6 | 6,241
psoriasis 6 | 6,694
adult high grade glioma 5 | 3,801
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung cancer 5 | 4,740
Schizophrenia 4 | 1,160
atypical teratoid / rhabdoid tumor 4 | 5,112
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
ependymoma 4 | 4,679
group 3 medulloblastoma 4 | 4,104
lung carcinoma 4 | 2,843
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Hypersensitivity reaction type II disease 3 | 253
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Multiple myeloma 3 | 1,332
Primary immunodeficiency disease 3 | 54
Renal Cell Carcinoma 3 | 214
Rheumatoid arthritis 3 | 1,191
Waldenstrons macroglobulinemia 3 | 765
astrocytic glioma 3 | 2,597
diabetes mellitus 3 | 1,728
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
juvenile dermatomyositis 3 | 1,187
malignant mesothelioma 3 | 3,232
pancreatic cancer 3 | 2,398
primary Sjogren syndrome 3 | 735
ulcerative colitis 3 | 1,819
Adult T-Cell Lymphoma/Leukemia 2 | 30
Allergic hypersensitivity disease 2 | 126
Alzheimer's disease 2 | 658
Asthma 2 | 385
Atopic dermatitis 2 | 952
Blastic phase chronic myeloid leukemia 2 | 58
Breast cancer 2 | 3,578
Chronic Lymphocytic Leukemia 2 | 262
Chronic Myelocytic Leukemia Accelerated Phase 2 | 59
Chronic phase chronic myeloid leukemia 2 | 45
Dermatitis 2 | 157
Hepatitis B 2 | 108
Human immunodeficiency virus infectious disease 2 | 138
Inflammatory bowel disease 2 | 151
Influenza 2 | 142
Intellectual disability 2 | 1,016
Juvenile idiopathic arthritis 2 | 3
Leukemia-Lymphoma, Adult T-Cell 2 | 30
Liver diseases 2 | 87
Melanoma 2 | 711
Multiple Sclerosis 2 | 540
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 2 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 2 | 47
Pick disease 2 | 1,894
Proteinuria 2 | 144
Renal transplant rejection 2 | 13
Tetanus 2 | 68
gastric cancer 2 | 459
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
Adenocarcinoma of lung 1 | 142
Alcoholic Intoxication 1 | 34
Alcoholic Intoxication, Chronic 1 | 289
Autoimmune Diseases 1 | 67
Breast Neoplasms 1 | 445
Flat face 1 | 52
HIV Infections 1 | 102
Heart failure 1 | 162
Highly variable severity 1 | 157
Infantile onset 1 | 238
Large auricle 1 | 87
Large dysplastic ears 1 | 87
Large pinnae 1 | 87
Large prominent ears 1 | 87
Large protruding ears 1 | 87
Large, floppy ears 1 | 87
Liver disease 1 | 237
Lymphopenia 1 | 67
Macrotia 1 | 87
Mammary Neoplasms 1 | 425
Necrosis 1 | 53
Neoplasm Metastasis 1 | 168
Peripheral T-cell lymphoma 1 | 25
Recurrent respiratory infections 1 | 141
Systemic lupus erythematosus 1 | 194
Variable expressivity 1 | 157
head and neck cancer and chronic obstructive pulmonary disease 1 | 239
sarcoidosis 1 | 370

Tissue

Blood and immune system 11 | 16,909
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678
Cardiovascular System 10 | 15,192

Target Family

Kinase 5 | 634
Non-IDG 4 | 12,091
Enzyme 2 | 4,145

Reactome Pathway

CD28 dependent Vav1 pathway 11 | 11
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Serine/threonine-protein kinase PAK 3 PAK3 Tchem Kinase -1.35059 21.1 377
T-lymphocyte activation antigen CD80 CD80 Tclin Non-IDG -3.39216 2405.6 1323
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Proto-oncogene vav VAV1 Tchem Non-IDG -2.66356 489.1 548
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Tyrosine-protein kinase Fyn FYN Tclin Kinase -3.03132 1021.2 726
T-lymphocyte activation antigen CD86 CD86 Tclin Non-IDG -3.48463 2838.9 1288
Tyrosine-protein kinase Lck LCK Tclin Kinase -3.17774 1500.3 1180