Development Level

Tchem 12 | 1,598
Tbio 11 | 11,445
Tclin 9 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
embryonic lethality prior to t... 2 | 278
increased blood urea nitrogen ... 2 | 48
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
anophthalmia 1 | 33
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
increased CD4-positive, alpha ... 1 | 4
increased cardiac stroke volum... 1 | 1
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 27 | 11,493
ovarian cancer 22 | 8,520
Cancer 21 | 2,499
osteosarcoma 21 | 7,950
psoriasis 17 | 6,694
invasive ductal carcinoma 13 | 2,951
glioblastoma 12 | 5,792
lung cancer 12 | 4,740
medulloblastoma, large-cell 12 | 6,241
Breast cancer 10 | 3,578
Astrocytoma, Pilocytic 9 | 3,081
atypical teratoid / rhabdoid tumor 9 | 5,112
cystic fibrosis 9 | 1,696
diabetes mellitus 9 | 1,728
interstitial cystitis 9 | 2,312
juvenile dermatomyositis 9 | 1,187
Kidney cancer 8 | 2,613
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 2,010
Rheumatoid arthritis 7 | 1,191
adult high grade glioma 7 | 3,801
ependymoma 7 | 4,679
group 4 medulloblastoma 7 | 1,855
lung carcinoma 7 | 2,843
oligodendroglioma 7 | 2,850
pancreatic cancer 7 | 2,398
Epilepsy 6 | 792
Renal Cell Carcinoma 6 | 214
Schizophrenia 6 | 1,160
cutaneous lupus erythematosus 6 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
Autosomal recessive predisposition 5 | 1,442
Blastic phase chronic myeloid leukemia 5 | 58
Breast Neoplasms 5 | 445
Chronic Myelocytic Leukemia Accelerated Phase 5 | 59
Intellectual disability 5 | 1,016
Liver Cirrhosis, Experimental 5 | 769
Mammary Neoplasms 5 | 425
Pick disease 5 | 1,894
Seizures 5 | 596
astrocytic glioma 5 | 2,597
ductal carcinoma in situ 5 | 1,745
pituitary cancer 5 | 1,972
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Carcinoma, Hepatocellular 4 | 228
Chronic phase chronic myeloid leukemia 4 | 45
Liver carcinoma 4 | 240
Multiple myeloma 4 | 1,332
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 4 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 4 | 47
Ventricular Septal Defects 4 | 119
Waldenstrons macroglobulinemia 4 | 765
breast carcinoma 4 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
non primary Sjogren syndrome sicca 4 | 891
primary Sjogren syndrome 4 | 735
Allergic hypersensitivity disease 3 | 126
Alzheimer's disease 3 | 658
Anemia 3 | 365
Arthritis 3 | 290
Atopic dermatitis 3 | 952
Chronic Lymphocytic Leukemia 3 | 262
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Diarrhea 3 | 253
Endometrial cancer 3 | 311
Failure to gain weight 3 | 365
Frontal bossing 3 | 157
High forehead 3 | 102
Hypersensitivity reaction type II disease 3 | 253
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Influenza 3 | 142
Kidney disease 3 | 430
Microstomia 3 | 78
Parkinson's disease 3 | 392
Pediatric failure to thrive 3 | 365
Polycystic ovary syndrome 3 | 360
Polymicrogyria 3 | 48
Stomach Neoplasms 3 | 300
Tall forehead 3 | 102
Telecanthus 3 | 62
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
colon cancer 3 | 1,478
dermatomyositis 3 | 966
gastric carcinoma 3 | 807
nasopharyngeal carcinoma 3 | 1,058
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Cardiovascular System 31 | 15,192

Target Family

Kinase 17 | 634
Non-IDG 10 | 12,091
Enzyme 5 | 4,145

Reactome Pathway

CD28 co-stimulation 32 | 32
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Proline-rich protein 5 PRR5 Tbio Non-IDG -1.13287 3.70 143
Serine/threonine-protein kinase PAK 3 PAK3 Tchem Kinase -1.35059 21.1 377
T-lymphocyte activation antigen CD80 CD80 Tclin Non-IDG -3.39216 2405.6 1323
Target of rapamycin complex 2 subunit MAPKAP1 MAPKAP1 Tbio Non-IDG -2.01676 101.3 244
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Proto-oncogene vav VAV1 Tchem Non-IDG -2.66356 489.1 548
Mitogen-activated protein kinase kinase kinase 8 MAP3K8 Tchem Kinase -2.09230 154.3 433
Target of rapamycin complex subunit LST8 MLST8 Tbio Non-IDG -2.64631 429.3 360