Development Level

Tchem 13 | 1,598
Tbio 4 | 11,445
Tclin 3 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 979
increased blood urea nitrogen ... 2 | 48
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal skin condition 1 | 6
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
prenatal lethality 1 | 28
short tibia 1 | 97
thrombocytopenia 1 | 56

Disease

Carcinoma 17 | 11,493
ovarian cancer 16 | 8,520
Cancer 14 | 2,499
glioblastoma 13 | 5,792
lung cancer 12 | 4,740
osteosarcoma 11 | 7,950
psoriasis 10 | 6,694
Kidney cancer 9 | 2,613
atypical teratoid / rhabdoid tumor 9 | 5,112
medulloblastoma, large-cell 9 | 6,241
Breast cancer 8 | 3,578
adult high grade glioma 8 | 3,801
ependymoma 8 | 4,679
Byzanthine arch palate 7 | 194
Multiple myeloma 7 | 1,332
Renal Cell Carcinoma 7 | 214
Schizophrenia 7 | 1,160
Short stature 7 | 531
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
malignant mesothelioma 7 | 3,232
oligodendroglioma 7 | 2,850
Blepharoptosis 6 | 231
Breast Neoplasms 6 | 445
Cardiac Arrhythmia 6 | 103
Cardiac conduction abnormalities 6 | 78
Conduction disorder of the heart 6 | 79
Cryptorchidism 6 | 296
Delayed bone age 6 | 136
Downward slant of palpebral fissure 6 | 158
Dull intelligence 6 | 645
EKG abnormalities 6 | 78
Electrocardiogram abnormal 6 | 81
Electrocardiogram change 6 | 78
Epilepsy 6 | 792
Hypoplastic mandible condyle 6 | 275
Intellectual disability 6 | 1,016
Low intelligence 6 | 645
Low set ears 6 | 181
Mammary Neoplasms 6 | 425
Mandibular hypoplasia 6 | 275
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Micrognathism 6 | 275
Muscle hypotonia 6 | 571
Poor school performance 6 | 645
Seizures 6 | 596
Stomach Neoplasms 6 | 300
Strabismus 6 | 270
astrocytic glioma 6 | 2,597
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
juvenile dermatomyositis 6 | 1,187
lung carcinoma 6 | 2,843
pancreatic cancer 6 | 2,398
Acquired scoliosis 5 | 281
Astrocytoma, Pilocytic 5 | 3,081
Congenital Epicanthus 5 | 177
Congenital ocular coloboma (disorder) 5 | 40
Curvature of spine 5 | 282
Electroencephalogram abnormal 5 | 101
Exophthalmos 5 | 112
Feeding difficulties in infancy 5 | 175
Frontal bossing 5 | 157
Hyperreflexia 5 | 209
Isolated cases 5 | 72
Low posterior hairline 5 | 52
Pectus excavatum 5 | 100
Prominent eyes 5 | 96
Prominent globes 5 | 96
Protruding eyes 5 | 96
Waldenstrons macroglobulinemia 5 | 765
astrocytoma 5 | 1,146
cystic fibrosis 5 | 1,696
group 4 medulloblastoma 5 | 1,855
interstitial cystitis 5 | 2,312
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Adenocarcinoma of lung 4 | 142
Alopecia 4 | 115
Atrial Septal Defects 4 | 85
Bladder Neoplasm 4 | 112
Chronic Lymphocytic Leukemia 4 | 262
Endometrial cancer 4 | 311
Highly variable severity 4 | 157
Immune system cancer 4 | 140
Joint hyperflexibility 4 | 78
Melanoma 4 | 711
Mental and motor retardation 4 | 608
Muscle Weakness 4 | 170
Pick disease 4 | 1,894
Urinary Bladder Neoplasms 4 | 114
Variable expressivity 4 | 157
Ventricular Septal Defects 4 | 119
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
invasive ductal carcinoma 4 | 2,951
non-small cell lung cancer 4 | 2,890
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Endocrine System 20 | 18,159
Male tissues 20 | 17,142
Blood and immune system 19 | 16,909
Cardiovascular System 19 | 15,192
Digestive Tract 19 | 17,369
Female tissues 19 | 17,400
Liver and Pancreas 19 | 16,750
Nervous System 19 | 16,725
Respiratory system 19 | 16,393
Skin and soft tissues 19 | 17,230
Urinary Tract 19 | 16,678

Target Family

Kinase 10 | 634
Enzyme 3 | 4,145
Transcription Factor 3 | 1,400
Epigenetic 2 | 242
Non-IDG 2 | 12,091

Reactome Pathway

CD209 (DC-SIGN) signaling 20 | 20
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775
RAF proto-oncogene serine/threonine-protein kinase RAF1 Tclin Kinase -3.11577 1210.8 2254
Tyrosine-protein kinase Fyn FYN Tclin Kinase -3.03132 1021.2 726
Transcription factor p65 RELA Tchem Transcription Factor -3.00328 988.5 2215
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Tyrosine-protein kinase Lyn LYN Tclin Kinase -2.83644 683.2 589
Nuclear factor NF-kappa-B p105 subunit NFKB1 Tchem Transcription Factor -2.74349 505.0 1762
CREB-binding protein CREBBP Tchem Epigenetic -2.81657 471.6 449