Development Level

Tbio 98 | 11,651
Tchem 28 | 1,388
Tclin 11 | 612
Tdark 5 | 6,593

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 6 | 499
abnormal bone structure 3 | 187
abnormal lens morphology 2 | 81
decreased circulating choleste... 2 | 93
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
embryonic lethality prior to t... 2 | 278
increased blood urea nitrogen ... 2 | 48
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal maxilla morphology 1 | 17
abnormal skin condition 1 | 6
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating free fat... 1 | 31
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small epididymis 1 | 3
thrombocytopenia 1 | 56

Disease

ovarian cancer 89 | 8,520
Carcinoma 84 | 11,493
lung cancer 67 | 4,740
psoriasis 64 | 6,694
osteosarcoma 60 | 7,950
glioblastoma 52 | 5,792
Cancer 51 | 2,499
Multiple myeloma 41 | 1,332
Breast cancer 37 | 3,578
medulloblastoma, large-cell 35 | 6,241
ependymoma 32 | 4,679
adult high grade glioma 31 | 3,801
malignant mesothelioma 31 | 3,232
atypical teratoid / rhabdoid tumor 30 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
Kidney cancer 29 | 2,613
subependymal giant cell astrocytoma 28 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
lung carcinoma 26 | 2,843
dermatomyositis 25 | 966
pancreatic cancer 25 | 2,398
Astrocytoma, Pilocytic 24 | 3,081
non-small cell lung cancer 24 | 2,890
oligodendroglioma 24 | 2,850
lung adenocarcinoma 22 | 2,716
tuberculosis 22 | 2,010
Waldenstrons macroglobulinemia 21 | 765
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
astrocytic glioma 20 | 2,597
interstitial cystitis 20 | 2,312
ulcerative colitis 20 | 1,819
group 3 medulloblastoma 19 | 4,104
invasive ductal carcinoma 18 | 2,951
HIV Infections 17 | 102
astrocytoma 17 | 1,146
Pick disease 16 | 1,894
diabetes mellitus 16 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
cystic fibrosis 15 | 1,696
group 4 medulloblastoma 15 | 1,855
Liver Cirrhosis, Experimental 13 | 769
Rheumatoid arthritis 12 | 1,191
Stomach Neoplasms 12 | 300
juvenile dermatomyositis 12 | 1,187
primary pancreatic ductal adenocarcinoma 12 | 1,109
primitive neuroectodermal tumor 12 | 3,035
Autosomal recessive predisposition 11 | 1,442
Breast Neoplasms 11 | 445
Liver cancer 11 | 604
Mammary Neoplasms 11 | 425
Seizures 11 | 596
colon cancer 11 | 1,478
cutaneous lupus erythematosus 11 | 1,057
esophageal adenocarcinoma 11 | 737
non primary Sjogren syndrome sicca 11 | 891
primary Sjogren syndrome 11 | 735
Anemia 10 | 365
Asthma 10 | 385
Atopic dermatitis 10 | 952
Osteoporosis 10 | 363
Renal Cell Carcinoma 10 | 214
Short stature 10 | 531
Endometrial cancer 9 | 311
Epilepsy 9 | 792
Intellectual disability 9 | 1,016
Melanoma 9 | 711
Pneumonia 9 | 174
Schizophrenia 9 | 1,160
breast carcinoma 9 | 1,638
Byzanthine arch palate 8 | 194
Dull intelligence 8 | 645
Hypoplastic mandible condyle 8 | 275
Immune system cancer 8 | 140
Large intestine cancer 8 | 126
Low intelligence 8 | 645
Lymphoid leukemia 8 | 160
Mandibular hypoplasia 8 | 275
Mantle cell lymphoma 8 | 23
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Micrognathism 8 | 275
Poor school performance 8 | 645
active ulcerative colitis 8 | 764
acute myeloid leukemia 8 | 783
acute quadriplegic myopathy 8 | 1,158
nasopharyngeal carcinoma 8 | 1,058
Acquired scoliosis 7 | 281
Arthritis 7 | 290
Bipolar Disorder 7 | 666
Crohn's disease 7 | 321
Curvature of spine 7 | 282
Frontal bossing 7 | 157
Lung Neoplasms 7 | 232
Muscle hypotonia 7 | 571
Splenomegaly 7 | 190
Strabismus 7 | 270
active Crohn's disease 7 | 922
ductal carcinoma in situ 7 | 1,745
mucosa-associated lymphoid tissue lymphoma 7 | 484
pituitary cancer 7 | 1,972

Tissue

Digestive Tract 136 | 17,369
Endocrine System 134 | 18,159
Female tissues 134 | 17,400
Skin and soft tissues 134 | 17,230
Blood and immune system 132 | 16,909
Respiratory system 132 | 16,393
Urinary Tract 131 | 16,678
Liver and Pancreas 130 | 16,750
Male tissues 130 | 17,142
Nervous System 126 | 16,725
Cardiovascular System 123 | 15,192

Target Family

Non-IDG 59 | 12,091
Enzyme 51 | 4,145
Kinase 20 | 634
Transcription Factor 7 | 1,400
Ion Channel 3 | 344
Epigenetic 2 | 242

Reactome Pathway

C-type lectin receptors (CLRs) 142 | 142
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
C-type lectin domain family 6 member A CLEC6A Tbio Non-IDG -1.54098 33.3 328
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.75887 5.88 183
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
C-type lectin domain family 4 member E CLEC4E Tbio Non-IDG -1.74401 58.6 164