Development Level

Tbio 75 | 10,625
Tchem 51 | 1,890
Tclin 11 | 602
Tdark 4 | 7,003

Collection

Eligible Kinase Proteins 4 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 8 | 633
decreased lean body mass 5 | 195
abnormal lens morphology 3 | 73
preweaning lethality, incomple... 3 | 260
abnormal bone structure 2 | 131
abnormal cornea morphology 2 | 24
decreased bone mineral content 2 | 157
decreased circulating choleste... 2 | 85
embryonic lethality prior to t... 2 | 187
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin condition 1 | 6
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
decreased B cell number 1 | 30
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating free fat... 1 | 39
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased macrophage cell numb... 1 | 4
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased thermal nociceptive ... 1 | 4
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased startle reflex 1 | 38
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
small epididymis 1 | 3

Disease

ovarian cancer 89 | 8,484
psoriasis 64 | 6,685
lung cancer 61 | 4,466
osteosarcoma 61 | 7,933
glioblastoma 51 | 5,572
Cancer 50 | 2,346
Multiple myeloma 41 | 1,327
medulloblastoma, large-cell 36 | 6,234
Breast cancer 31 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,289
atypical teratoid / rhabdoid tumor 29 | 4,369
subependymal giant cell astrocytoma 28 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,988
malignant mesothelioma 27 | 3,162
lung carcinoma 26 | 2,844
pilocytic astrocytoma 26 | 3,086
dermatomyositis 25 | 933
pancreatic cancer 25 | 2,300
ulcerative colitis 25 | 2,087
oligodendroglioma 24 | 2,849
Carcinoma 23 | 2,147
ependymoma 23 | 2,514
lung adenocarcinoma 23 | 2,713
non-small cell lung cancer 22 | 2,798
Waldenstrons macroglobulinemia 21 | 765
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
astrocytoma 20 | 1,493
interstitial cystitis 20 | 2,299
pediatric high grade glioma 19 | 2,712
invasive ductal carcinoma 18 | 2,950
tuberculosis 18 | 1,557
HIV Infections 17 | 100
astrocytic glioma 17 | 2,241
Pick disease 16 | 1,893
adult high grade glioma 15 | 2,148
cystic fibrosis 15 | 1,665
diabetes mellitus 15 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
medulloblastoma 13 | 1,524
primary pancreatic ductal adenocarcinoma 13 | 1,271
primitive neuroectodermal tumor 13 | 3,031
Rheumatoid Arthritis 12 | 1,160
group 4 medulloblastoma 12 | 1,875
juvenile dermatomyositis 12 | 1,189
colon cancer 11 | 1,475
cutaneous lupus erythematosus 11 | 1,056
esophageal adenocarcinoma 11 | 737
group 3 medulloblastoma 11 | 2,254
non primary Sjogren syndrome sicca 11 | 840
primary Sjogren syndrome 11 | 789
Mammary Neoplasms 10 | 410
Atopic dermatitis 9 | 944
Stomach Neoplasms 9 | 282
acute quadriplegic myopathy 9 | 1,157
posterior fossa group A ependymoma 9 | 1,511
Asthma 8 | 349
Mantle cell lymphoma 8 | 18
acute myeloid leukemia 8 | 780
breast carcinoma 8 | 1,614
nasopharyngeal carcinoma 8 | 1,056
Arthritis 7 | 248
Kidney cancer 7 | 118
Lung Neoplasms 7 | 171
Obesity 7 | 616
Osteoporosis 7 | 257
Renal Cell Carcinoma 7 | 199
active Crohn's disease 7 | 918
ductal carcinoma in situ 7 | 1,745
gastric carcinoma 7 | 832
non-small cell lung carcinoma 7 | 413
pituitary cancer 7 | 1,972
tuberculosis and treatment for 6 months 7 | 686
Adenocarcinoma 6 | 115
Adenoma 6 | 165
Bladder Neoplasm 6 | 109
Crohn's disease 6 | 304
IGA Glomerulonephritis 6 | 454
Intellectual disability 6 | 573
Parkinson's disease 6 | 364
Prostatic Neoplasms 6 | 471
Schizophrenia 6 | 501
mucosa-associated lymphoid tissue lymphoma 6 | 480
periodontitis 6 | 269
spina bifida 6 | 1,064
Allergic hypersensitivity disease 5 | 123
Alzheimer's disease 5 | 644
Chronic Lymphocytic Leukemia 5 | 242
Colonic Neoplasms 5 | 126
Colorectal Neoplasms 5 | 217
Heat Stroke 5 | 12
Liver carcinoma 5 | 217
Lymphoma 5 | 56
Melanoma 5 | 261
Myocardial Ischemia 5 | 169
Noonan Syndrome 5 | 33
Otitis media 5 | 32
sarcoidosis 5 | 358
sonic hedgehog group medulloblastoma 5 | 1,482
Endometriosis 4 | 535
aldosterone-producing adenoma 4 | 664

Tissue

Digestive Tract 139 | 18,473
Urinary Tract 139 | 18,444
Blood and immune system 138 | 17,995
Cardiovascular System 138 | 17,958
Endocrine System 138 | 18,512
Female tissues 138 | 18,647
Liver and Pancreas 138 | 18,136
Nervous System 138 | 18,561
Respiratory system 138 | 17,484
Male tissues 137 | 17,969
Skin and soft tissues 136 | 18,115

Target Family

Non-IDG 57 | 11,971
Enzyme 52 | 4,146
Kinase 20 | 634
Transcription Factor 7 | 1,400
Ion Channel 3 | 341
Epigenetic 2 | 242

Reactome Pathway

C-type lectin receptors (CLRs) 141 | 141
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.08055 124.6 194
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.83055 69.0 145
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34160 1960.9 1181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150