Development Level

Tbio 14 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
abnormal vitreous body morphol... 1 | 10
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased heart weight 1 | 62
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87

Disease

osteosarcoma 15 | 7,950
ovarian cancer 10 | 8,520
group 3 medulloblastoma 7 | 4,104
Carcinoma 6 | 11,493
medulloblastoma, large-cell 6 | 6,241
atypical teratoid / rhabdoid tumor 5 | 5,112
psoriasis 5 | 6,694
astrocytic glioma 4 | 2,597
glioblastoma 4 | 5,792
primitive neuroectodermal tumor 4 | 3,035
Waldenstrons macroglobulinemia 3 | 765
acute quadriplegic myopathy 3 | 1,158
colon cancer 3 | 1,478
dermatomyositis 3 | 966
ependymoma 3 | 4,679
juvenile dermatomyositis 3 | 1,187
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
medulloblastoma 3 | 720
oligodendroglioma 3 | 2,850
Autosomal recessive predisposition 2 | 1,442
Cerebral atrophy 2 | 178
Cognitive delay 2 | 608
Feeding difficulties 2 | 127
Global developmental delay 2 | 608
Kidney cancer 2 | 2,613
Mental and motor retardation 2 | 608
Multiple myeloma 2 | 1,332
Neurodegenerative disease 2 | 414
Pontocerebellar Hypoplasia Type 1 2 | 5
Pontocerebellar hypoplasia 2 | 36
X-linked cerebral adrenoleukodystrophy 2 | 116
acute myeloid leukemia 2 | 783
adult high grade glioma 2 | 3,801
diabetes mellitus 2 | 1,728
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Absent speech 1 | 43
Alzheimer's disease 1 | 658
Amyotrophic lateral sclerosis 1 | 451
Atrophy of cerebellum 1 | 103
Cerebellar degeneration 1 | 103
Contracture 1 | 96
Contracture of joint 1 | 93
Deafness 1 | 198
Disease Progression 1 | 136
Down syndrome 1 | 499
Failure to gain weight 1 | 365
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Foot Deformities 1 | 30
Gastric antral vascular ectasia 1 | 10
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Highly variable severity 1 | 157
Hyperreflexia 1 | 209
Hypoplasia of corpus callosum 1 | 90
Infratentorial atrophy 1 | 103
Leukemia 1 | 104
Liver cancer 1 | 604
Liver neoplasms 1 | 130
Low Vision 1 | 174
Multiple Sclerosis 1 | 540
Muscle Spasticity 1 | 195
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Parkinson's disease 1 | 392
Pediatric failure to thrive 1 | 365
Pilocytic astrocytoma 1 | 56
Polyhydramnios 1 | 108
Poor growth 1 | 114
Prenatal onset 1 | 139
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Skeletal muscle atrophy 1 | 139
Stomach Neoplasms 1 | 300
Strabismus 1 | 270
Variable expressivity 1 | 157
Very poor growth 1 | 114
Visual Impairment 1 | 174
breast carcinoma 1 | 1,638
cystic fibrosis 1 | 1,696
glioblastoma multiforme 1 | 142
hepatocellular carcinoma 1 | 547
limb girdle muscular dystrophy 2I 1 | 32
muscle degeneration 1 | 139
nonverbal 1 | 43
pancreatic carcinoma 1 | 562
pediatric high grade glioma 1 | 1,064

Tissue

Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Enzyme 9 | 4,145
Non-IDG 6 | 12,091
Kinase 1 | 634

Reactome Pathway

Butyrate Response Factor 1 (BR... 16 | 16
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exosome complex exonuclease RRP44 DIS3 Tbio Enzyme -1.80730 64.2 141
Exosome complex component RRP4 EXOSC2 Tbio Non-IDG -0.28065 2.13 121
mRNA decay activator protein ZFP36L1 ZFP36L1 Tbio Non-IDG -1.51339 38.6 285
5'-3' exoribonuclease 1 XRN1 Tbio Enzyme -2.13482 125.3 51
Exosome complex component MTR3 EXOSC6 Tbio Enzyme -0.78888 5.11 84
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113
Exosome complex component RRP45 EXOSC9 Tbio Enzyme -1.17714 13.5 92
Exosome complex component RRP46 EXOSC5 Tbio Enzyme -1.31759 21.1 114
Exosome complex component CSL4 EXOSC1 Tbio Non-IDG -2.07438 110.2 129
MAP kinase-activated protein kinase 2 MAPKAPK2 Tchem Kinase -2.16502 140.7 702