Development Level

Tbio 18 | 11,445
Tchem 4 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal behavior 1 | 298
abnormal craniofacial morpholo... 1 | 33
abnormal forebrain morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal skin morphology 1 | 50
decreased circulating alkaline... 1 | 46
decreased fasted circulating g... 1 | 65
decreased heart rate 1 | 18
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
male infertility 1 | 123
polydactyly 1 | 7
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
prolonged RR interval 1 | 8

Disease

Carcinoma 16 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
ovarian cancer 12 | 8,520
Autosomal recessive predisposition 10 | 1,442
Maple syrup urine disease 10 | 24
Seizures 10 | 596
atypical teratoid / rhabdoid tumor 10 | 5,112
medulloblastoma, large-cell 10 | 6,241
Epilepsy 9 | 792
ependymoma 9 | 4,679
osteosarcoma 9 | 7,950
Muscle hypotonia 8 | 571
glioblastoma 8 | 5,792
interstitial cystitis 8 | 2,312
psoriasis 8 | 6,694
ulcerative colitis 8 | 1,819
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
Dull intelligence 6 | 645
Hypoglycemia 6 | 152
Intellectual disability 6 | 1,016
Lethargy 6 | 77
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
adult high grade glioma 6 | 3,801
Acidosis, Lactic 5 | 97
Breast cancer 5 | 3,578
Cerebellar Ataxia 5 | 304
Lactic acidemia 5 | 95
Metabolic acidosis 5 | 90
Vomiting 5 | 116
gastric carcinoma 5 | 807
invasive ductal carcinoma 5 | 2,951
lung cancer 5 | 4,740
oligodendroglioma 5 | 2,850
Comatose 4 | 56
Dystonia 4 | 164
Dystonic disease 4 | 106
Hallucinations 4 | 34
Hallucinations, Sensory 4 | 33
Infantile onset 4 | 238
Intermediate Maple Syrup Urine Disease 4 | 4
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung carcinoma 4 | 2,843
nephrosclerosis 4 | 333
pancreatic cancer 4 | 2,398
primitive neuroectodermal tumor 4 | 3,035
3-Methylcrotonyl-CoA carboxylase deficiency 3 | 11
Astrocytoma, Pilocytic 3 | 3,081
Autistic Disorder 3 | 364
Brain Edema 3 | 50
Cerebral Edema 3 | 30
Classic Maple Syrup Urine Disease 3 | 3
Crohn's disease 3 | 321
Elevated plasma branched chain amino acids 3 | 3
Feeding difficulties 3 | 127
Feeding difficulties in infancy 3 | 175
Intermittent Maple Syrup Urine Disease 3 | 3
Ketonemia 3 | 11
Ketosis 3 | 11
Liver Cirrhosis, Experimental 3 | 769
Maple Syrup Urine Disease, Thiamine Responsive 3 | 3
Motor delay 3 | 147
Multiple myeloma 3 | 1,332
Muscle Hypertonia 3 | 88
No development of motor milestones 3 | 147
Pancreatitis 3 | 123
Pick disease 3 | 1,894
Small head 3 | 374
abnormal growth 3 | 26
adrenocortical carcinoma 3 | 1,428
astrocytic glioma 3 | 2,597
beta-ketothiolase deficiency 3 | 13
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
esophageal adenocarcinoma 3 | 737
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
pituitary cancer 3 | 1,972
tuberculosis 3 | 2,010
Cancer 2 | 2,499
Congenital Epicanthus 2 | 177
Language Delay 2 | 112
Speech Delay 2 | 112
Speech impairment 2 | 112
Waldenstrons macroglobulinemia 2 | 765
aldosterone-producing adenoma 2 | 665
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
medulloblastoma 2 | 720
pancreatic carcinoma 2 | 562

Tissue

Blood and immune system 22 | 16,909
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678
Cardiovascular System 21 | 15,192

Target Family

Enzyme 21 | 4,145
Kinase 1 | 634

Reactome Pathway

Branched-chain amino acid cata... 22 | 22
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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