Development Level

Tbio 58 | 11,445
Tchem 10 | 1,598
Tdark 9 | 6,588

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 5 | 278
abnormal embryo size 3 | 220
embryonic growth retardation 3 | 106
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
bleb 2 | 2
decreased fasted circulating g... 2 | 65
enlarged heart 2 | 210
increased fasted circulating g... 2 | 76
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal limb bud morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cataract 1 | 92
convulsive seizures 1 | 13
decreased basophil cell number 1 | 16
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating lipase l... 1 | 3
decreased circulating magnesiu... 1 | 13
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 46 | 11,493
ovarian cancer 44 | 8,520
osteosarcoma 27 | 7,950
Congenital disorder of glycosylation 24 | 54
Autosomal recessive predisposition 23 | 1,442
glioblastoma 23 | 5,792
psoriasis 23 | 6,694
atypical teratoid / rhabdoid tumor 21 | 5,112
medulloblastoma, large-cell 21 | 6,241
Epilepsy 18 | 792
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Muscle hypotonia 15 | 571
Seizures 15 | 596
ependymoma 15 | 4,679
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
invasive ductal carcinoma 15 | 2,951
lung cancer 15 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
tuberculosis 15 | 2,010
Breast cancer 14 | 3,578
Astrocytoma, Pilocytic 13 | 3,081
Intellectual disability 13 | 1,016
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
malignant mesothelioma 13 | 3,232
Cognitive delay 12 | 608
Global developmental delay 12 | 608
Mental and motor retardation 12 | 608
non-small cell lung cancer 12 | 2,890
pancreatic cancer 12 | 2,398
Cerebellar Ataxia 11 | 304
lung adenocarcinoma 11 | 2,716
lung carcinoma 11 | 2,843
Multiple myeloma 10 | 1,332
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
adult high grade glioma 9 | 3,801
astrocytic glioma 9 | 2,597
diabetes mellitus 9 | 1,728
ulcerative colitis 9 | 1,819
Failure to gain weight 8 | 365
Hepatomegaly 8 | 285
Pediatric failure to thrive 8 | 365
Small head 8 | 374
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
subependymal giant cell astrocytoma 8 | 2,287
Isoelectric focusing of serum transferrin consistent with CDG type I 7 | 10
Nystagmus 7 | 317
Optic Atrophy 7 | 242
Strabismus 7 | 270
oligodendroglioma 7 | 2,850
primitive neuroectodermal tumor 7 | 3,035
Acquired scoliosis 6 | 281
Byzanthine arch palate 6 | 194
Cerebral atrophy 6 | 178
Coarse facial features 6 | 108
Curvature of spine 6 | 282
Kidney cancer 6 | 2,613
Splenomegaly 6 | 190
Thickened facial skin with coarse facial features 6 | 108
acute myeloid leukemia 6 | 783
pediatric high grade glioma 6 | 1,064
pituitary cancer 6 | 1,972
Cancer 5 | 2,499
Creatine phosphokinase serum increased 5 | 110
Elevated creatine kinase 5 | 110
Glycoproteinosis 5 | 12
Schizophrenia 5 | 1,160
active Crohn's disease 5 | 922
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
cystic fibrosis 5 | 1,696
ductal carcinoma in situ 5 | 1,745
nasopharyngeal carcinoma 5 | 1,058
pancreatic carcinoma 5 | 562
primary pancreatic ductal adenocarcinoma 5 | 1,109
spina bifida 5 | 1,074
Cardiomyopathy, Dilated 4 | 83
Cataract 4 | 297
Congenital Epicanthus 4 | 177
Congenital muscular dystrophy 4 | 29
Congenital myasthenic syndrome 4 | 25
Diarrhea 4 | 253
Feeding difficulties 4 | 127
Gait abnormality 4 | 135
Highly variable severity 4 | 157
Impaired cognition 4 | 96
Mental impairment 4 | 95
Pick disease 4 | 1,894
Prenatal onset 4 | 139
Short stature 4 | 531
Variable expressivity 4 | 157
Vomiting 4 | 116
active ulcerative colitis 4 | 764
non primary Sjogren syndrome sicca 4 | 891
posterior fossa group A ependymoma 4 | 468

Tissue

Digestive Tract 76 | 17,369
Endocrine System 76 | 18,159
Female tissues 76 | 17,400
Liver and Pancreas 76 | 16,750
Nervous System 76 | 16,725
Skin and soft tissues 76 | 17,230
Blood and immune system 75 | 16,909
Cardiovascular System 75 | 15,192
Male tissues 75 | 17,142
Urinary Tract 74 | 16,678
Respiratory system 73 | 16,393

Target Family

Enzyme 69 | 4,145
Non-IDG 3 | 12,091
Transporter 3 | 473
Kinase 2 | 634

Reactome Pathway

Biosynthesis of the N-glycan p... 77 | 77
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase ALG10 Tbio Enzyme -1.32430 19.1 70
Uridine diphosphate glucose pyrophosphatase NUDT14 Tdark Enzyme -0.67608 5.47 45
N-acetylglucosamine-6-phosphate deacetylase AMDHD2 Tchem Enzyme -1.10834 6.96 87
Dolichol kinase DOLK Tbio Enzyme -1.89047 77.2 58
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase ALG8 Tbio Enzyme -1.12194 12.8 98
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 ST6GALNAC2 Tbio Enzyme -1.74190 55.6 59
Alpha-2,8-sialyltransferase 8B ST8SIA2 Tbio Enzyme -3.21526 1661.4 82
Sialidase-3 NEU3 Tbio Enzyme -2.02704 118.2 35
N-acylglucosamine 2-epimerase RENBP Tbio Enzyme -1.54336 33.7 87