Development Level

Tchem 11 | 1,598
Tclin 4 | 613
Tbio 3 | 11,445

IMPC Phenotype

hydrometra 2 | 53
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
decreased lymphocyte cell numb... 1 | 83
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
preweaning lethality, complete... 1 | 979
small superior vagus ganglion 1 | 74

Disease

Cancer 12 | 2,499
Carcinoma 11 | 11,493
osteosarcoma 11 | 7,950
ovarian cancer 10 | 8,520
psoriasis 10 | 6,694
glioblastoma 8 | 5,792
lung carcinoma 8 | 2,843
medulloblastoma, large-cell 8 | 6,241
Drug-Related Side Effects and Adverse Reactions 7 | 62
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Adverse reaction to drug 6 | 61
Asthma 6 | 385
Chemical and Drug Induced Liver Injury 6 | 195
Liver disease 6 | 237
Schizophrenia 6 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
non-small cell lung cancer 6 | 2,890
tuberculosis 6 | 2,010
Atherosclerosis 5 | 291
Breast Neoplasms 5 | 445
Mammary Neoplasms 5 | 425
Prostatic Neoplasms 5 | 495
diabetes mellitus 5 | 1,728
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung cancer 5 | 4,740
pancreatic cancer 5 | 2,398
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Astrocytoma, Pilocytic 4 | 3,081
Hypertension 4 | 396
adrenocortical carcinoma 4 | 1,428
adult high grade glioma 4 | 3,801
atypical teratoid / rhabdoid tumor 4 | 5,112
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
ependymoma 4 | 4,679
lung adenocarcinoma 4 | 2,716
Acute kidney injury 3 | 70
Alzheimer's disease 3 | 658
Arthritis 3 | 290
Autosomal recessive predisposition 3 | 1,442
Carcinoma, Hepatocellular 3 | 228
Cerebrovascular disease 3 | 238
Colorectal Neoplasms 3 | 243
Coronary artery disease 3 | 268
Depressive disorder 3 | 409
Drug Eruptions 3 | 18
Endometriosis 3 | 540
Heart failure 3 | 162
Hypertensive disease 3 | 292
Liver Cirrhosis, Experimental 3 | 769
Liver carcinoma 3 | 240
Major Depressive Disorder 3 | 301
Malaria 3 | 160
Mental Depression 3 | 333
Nervous System Diseases 3 | 53
Osteoarthritis 3 | 184
Pain agnosia 3 | 104
Rheumatoid arthritis 3 | 1,191
Toxic encephalopathy 3 | 141
Unipolar Depression 3 | 250
Urticaria 3 | 67
aldosterone-producing adenoma 3 | 665
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
invasive ductal carcinoma 3 | 2,951
malignant mesothelioma 3 | 3,232
nasopharyngeal carcinoma 3 | 1,058
nervous system disorder 3 | 53
oligodendroglioma 3 | 2,850
periodontitis 3 | 293
Adenoma 2 | 167
Atrial Fibrillation 2 | 124
Cholestasis 2 | 155
Colitis 2 | 54
Colonic Neoplasms 2 | 142
Congenital clubfoot 2 | 109
Diarrhea 2 | 253
Heart disease 2 | 306
Hyperalgesia 2 | 83
Kidney disease 2 | 430
Liver diseases 2 | 87
Lung Neoplasms 2 | 232
Melanoma 2 | 711
Mood Disorders 2 | 184
Neoplasm Invasiveness 2 | 161
Parkinson Disease 2 | 64
Parkinson's disease 2 | 392
Proteinuria 2 | 144
Reperfusion Injury 2 | 86
Stomach Neoplasms 2 | 300
active Crohn's disease 2 | 922
adrenocortical adenoma 2 | 131
medulloblastoma 2 | 720
posterior fossa group B ependymoma 2 | 416
substance-related disorder 2 | 162
tuberculosis and treatment for 3 months 2 | 179

Tissue

Blood and immune system 18 | 16,909
Digestive Tract 18 | 17,369
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Endocrine System 17 | 18,159
Male tissues 17 | 17,142
Respiratory system 17 | 16,393
Nervous System 15 | 16,725
Cardiovascular System 13 | 15,192

Target Family

Enzyme 13 | 4,145
Non-IDG 5 | 12,091

Reactome Pathway

Biosynthesis of specialized pr... 18 | 18
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Prostaglandin reductase 1 PTGR1 Tbio Enzyme -1.28265 22.7 156
15-hydroxyprostaglandin dehydrogenase [NAD(+)] HPGD Tchem Enzyme -2.26841 191.0 354
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 Tbio Enzyme -2.88891 707.6 227
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.06834 12504.5 731
Glutathione S-transferase Mu 4 GSTM4 Tbio Enzyme -1.21233 13.7 95
Bifunctional epoxide hydrolase 2 EPHX2 Tchem Enzyme -2.57266 349.1 245
Leukotriene A-4 hydrolase LTA4H Tchem Enzyme -2.11151 125.3 291
Cytochrome P450 2C8 CYP2C8 Tchem Non-IDG -2.55207 348.9 159
Leukotriene C4 synthase LTC4S Tchem Enzyme -1.98032 93.9 89
Cytochrome P450 2D6 CYP2D6 Tclin Enzyme -3.53105 3484.9 433