Development Level

Tbio 102 | 10,625
Tchem 70 | 1,890
Tdark 22 | 7,003
Tclin 21 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
decreased lean body mass 3 | 195
increased startle reflex 3 | 38
preweaning lethality, complete... 3 | 633
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal heart left ventricle ... 2 | 20
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal sleep behavior 2 | 63
decreased body weight 2 | 174
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased heart rate 2 | 10
decreased mean platelet volume 2 | 12
decreased total body fat amoun... 2 | 186
hyperactivity 2 | 108
improved glucose tolerance 2 | 56
increased circulating HDL chol... 2 | 63
increased circulating alanine ... 2 | 11
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased grip strength 2 | 83
increased or absent threshold ... 2 | 128
oligodactyly 2 | 14
small kidney 2 | 10
straub tail 2 | 26
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal femur morphology 1 | 14
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal pelvic girdle bone mo... 1 | 11
abnormal radius morphology 1 | 8
abnormal response to tactile s... 1 | 16
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal scapula morphology 1 | 3
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
absent vibrissae 1 | 14
decreased B cell number 1 | 30
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased cervical vertebrae n... 1 | 12
decreased circulating calcium ... 1 | 33
decreased circulating creatini... 1 | 31
decreased circulating phosphat... 1 | 15
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased pulmonary respirator... 1 | 4
decreased red blood cell distr... 1 | 11
decreased spleen weight 1 | 13
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased bone mineral density 1 | 52
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased circulating triglyce... 1 | 24
increased fasted circulating g... 1 | 68
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased red blood cell distr... 1 | 21
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
short tibia 1 | 82
small heart 1 | 8
small ovary 1 | 1
small spleen 1 | 11
thin skin 1 | 1
thrombocytopenia 1 | 46

Disease

psoriasis 100 | 6,685
ovarian cancer 85 | 8,484
osteosarcoma 74 | 7,933
Cancer 61 | 2,346
lung cancer 59 | 4,466
medulloblastoma, large-cell 54 | 6,234
lung carcinoma 49 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 49 | 1,795
glioblastoma 46 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,956
lung adenocarcinoma 40 | 2,713
malignant mesothelioma 39 | 3,162
interstitial cystitis 38 | 2,299
invasive ductal carcinoma 38 | 2,950
Prostatic Neoplasms 36 | 471
atypical teratoid / rhabdoid tumor 34 | 4,369
non-small cell lung cancer 34 | 2,798
ulcerative colitis 34 | 2,087
Breast cancer 33 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,988
ductal carcinoma in situ 30 | 1,745
pancreatic cancer 29 | 2,300
adrenocortical carcinoma 26 | 1,427
tuberculosis 26 | 1,557
colon cancer 25 | 1,475
cystic fibrosis 25 | 1,665
pituitary cancer 24 | 1,972
pilocytic astrocytoma 23 | 3,086
pediatric high grade glioma 21 | 2,712
Liver disease 20 | 219
Peripheral Neuropathy 20 | 303
diabetes mellitus 20 | 1,663
breast carcinoma 19 | 1,614
oligodendroglioma 19 | 2,849
group 3 medulloblastoma 18 | 2,254
group 4 medulloblastoma 18 | 1,875
primitive neuroectodermal tumor 18 | 3,031
Alcohol dependence 17 | 107
Drug-Induced Liver Injury 17 | 118
astrocytic glioma 17 | 2,241
Pick disease 16 | 1,893
aldosterone-producing adenoma 16 | 664
esophageal adenocarcinoma 16 | 737
Mammary Neoplasms 15 | 410
Multiple myeloma 15 | 1,327
adult high grade glioma 15 | 2,148
nasopharyngeal carcinoma 15 | 1,056
Hypertension 14 | 287
Liver Cirrhosis, Experimental 14 | 108
chronic rhinosinusitis 14 | 512
nephrosclerosis 14 | 329
posterior fossa group A ependymoma 14 | 1,511
primary pancreatic ductal adenocarcinoma 14 | 1,271
Endometriosis 13 | 535
Lung Neoplasms 13 | 171
Schizophrenia 13 | 501
active Crohn's disease 13 | 918
acute quadriplegic myopathy 13 | 1,157
astrocytoma 13 | 1,493
ependymoma 13 | 2,514
posterior fossa group B ependymoma 13 | 1,530
subependymal giant cell astrocytoma 13 | 2,287
Congenital adrenal hyperplasia 12 | 74
Obesity 12 | 616
fibroadenoma 12 | 557
medulloblastoma 12 | 1,524
Bilirubin metabolic disorder 11 | 39
Cholestasis 11 | 93
Waldenstrons macroglobulinemia 11 | 765
cutaneous lupus erythematosus 11 | 1,056
Adenoma 10 | 165
Adverse reaction to drug 10 | 54
Bladder Neoplasm 10 | 109
gastric carcinoma 10 | 832
head and neck cancer and chronic obstructive pulmonary disease 10 | 237
non-small cell lung carcinoma 10 | 413
sonic hedgehog group medulloblastoma 10 | 1,482
Anemia 9 | 252
Asthma 9 | 349
Atherosclerosis 9 | 275
Atopic dermatitis 9 | 944
Attention deficit hyperactivity disorder 9 | 156
Colorectal Neoplasms 9 | 217
Contact Dermatitis 9 | 80
Down syndrome 9 | 548
Hypertensive disease 9 | 193
Liver carcinoma 9 | 217
Male infertility 9 | 170
Rheumatoid Arthritis 9 | 1,160
Substance abuse 9 | 55
pancreatic carcinoma 9 | 567
Alzheimer's disease 8 | 644
acute myeloid leukemia 8 | 780
head and neck cancer 8 | 270
hepatocellular carcinoma 8 | 532
inflammatory breast cancer 8 | 404
juvenile dermatomyositis 8 | 1,189
non primary Sjogren syndrome sicca 8 | 840
spina bifida 8 | 1,064

Tissue

Digestive Tract 214 | 18,473
Liver and Pancreas 214 | 18,136
Urinary Tract 214 | 18,444
Blood and immune system 211 | 17,995
Endocrine System 209 | 18,512
Female tissues 209 | 18,647
Nervous System 209 | 18,561
Skin and soft tissues 208 | 18,115
Cardiovascular System 202 | 17,958
Male tissues 202 | 17,969
Respiratory system 201 | 17,484

Target Family

Enzyme 167 | 4,146
Non-IDG 36 | 11,971
Transcription Factor 4 | 1,400
Transporter 4 | 473
Nuclear Receptor 2 | 48
Epigenetic 1 | 242
Ion Channel 1 | 341

Reactome Pathway

Biological oxidations 215 | 215
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glutathione S-transferase A5 GSTA5 Tdark Enzyme -1.03093 10.6 28
24-hydroxycholesterol 7-alpha-hydroxylase CYP39A1 Tbio Enzyme -0.95411 6.43 97
Glycine N-acyltransferase GLYAT Tbio Enzyme -1.86227 71.5 87
Sulfate transporter SLC26A2 Tbio Transporter -2.43817 275.5 68
Prostaglandin G/H synthase 1 PTGS1 Tclin Enzyme -3.20847 1594.9 391
Cytochrome P450 4V2 CYP4V2 Tbio Non-IDG -2.66290 481.8 87
Glutathione synthetase GSS Tbio Enzyme -2.75264 568.9 200
Aflatoxin B1 aldehyde reductase member 4 AKR7L Tdark Enzyme 15.0 0
Gamma-glutamylcyclotransferase GGCT Tbio Enzyme -2.15784 135.0 114
Retinal dehydrogenase 1 ALDH1A1 Tchem Enzyme -2.73036 583.4 632