Development Level

Tbio 8 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
preweaning lethality, incomple... 1 | 499

Disease

pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Carcinoma 6 | 11,493
ovarian cancer 6 | 8,520
psoriasis 6 | 6,694
Zellweger syndrome 5 | 37
medulloblastoma, large-cell 5 | 6,241
malignant mesothelioma 4 | 3,232
ulcerative colitis 4 | 1,819
Autosomal recessive predisposition 3 | 1,442
Bifunctional peroxisomal enzyme deficiency 3 | 3
Cognitive delay 3 | 608
Epilepsy 3 | 792
Global developmental delay 3 | 608
Mental and motor retardation 3 | 608
Seizures 3 | 596
Short stature 3 | 531
alpha-methylacyl-CoA racemase deficiency 3 | 9
atypical teratoid / rhabdoid tumor 3 | 5,112
lung cancer 3 | 4,740
osteosarcoma 3 | 7,950
Adrenoleukodystrophy 2 | 29
Chondrodysplasia punctata 2 | 41
Concave bridge of nose 2 | 195
Congenital Epicanthus 2 | 177
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Elevated hepatic transaminases 2 | 81
Failure to gain weight 2 | 365
Frontal bossing 2 | 157
Hepatic enzyme increased 2 | 81
Hepatomegaly 2 | 285
Infantile onset 2 | 238
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Low set ears 2 | 181
Metabolic acidosis 2 | 90
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Neonatal Hypotonia 2 | 64
Nystagmus 2 | 317
Orbital separation excessive 2 | 244
Pediatric failure to thrive 2 | 365
Peroxisomal acyl-CoA oxidase deficiency 2 | 4
Sensorineural Hearing Loss (disorder) 2 | 284
Strabismus 2 | 270
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
pancreatic cancer 2 | 2,398
spina bifida 2 | 1,074
Abdominal Pain 1 | 98
Abnormal vision 1 | 52
Abnormal visual evoked potential 1 | 26
Abnormality of metabolism/homeostasis 1 | 134
Big calvaria 1 | 147
Central nervous system demyelination 1 | 28
Cerebellar hypoplasia and atrophy 1 | 41
Cystic kidney 1 | 30
Death in early childhood 1 | 82
Death in infancy 1 | 82
Deglutition Disorders 1 | 132
Diabetes Mellitus, Experimental 1 | 108
Dysmyelination of the brain 1 | 6
Extinguished electroretinogram 1 | 15
Fatty liver disease 1 | 103
Generalized osteopenia 1 | 99
Genu varum 1 | 29
Hypertrophic Cardiomyopathy 1 | 117
Hypodontia 1 | 81
Increased head circumference 1 | 147
Increased size of cranium 1 | 147
Increased size of skull 1 | 147
Ketonemia 1 | 11
Ketosis 1 | 11
Leukodystrophy 1 | 55
Medium chain acyl-CoA dehydrogenase deficiency 1 | 13
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Neonatal adrenoleukodystrophy 1 | 14
Osteopenia 1 | 99
Osteoporosis 1 | 363
Progressive mental retardation 1 | 37
Renal cyst 1 | 30
Retrognathia 1 | 54
Rickets 1 | 49
Sensorineural hearing loss 1 | 106
Severe psychomotor retardation 1 | 47
Tall forehead 1 | 102
Turridolichocephaly 1 | 75
Very long chain acyl-CoA dehydrogenase deficiency 1 | 10
West Syndrome 1 | 28
White matter dysmyelination/demyelination 1 | 6

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Enzyme 8 | 4,145
Non-IDG 2 | 12,091

Reactome Pathway

Beta-oxidation of very long ch... 10 | 10
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Malonyl-CoA decarboxylase, mitochondrial MLYCD Tchem Enzyme -1.70434 46.1 67
Acyl-coenzyme A thioesterase 4 ACOT4 Tbio Enzyme -0.53787 2.87 58
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.17283 152.2 275
Peroxisomal bifunctional enzyme EHHADH Tbio Non-IDG -2.05616 109.3 204
Enoyl-CoA delta isomerase 2, mitochondrial ECI2 Tbio Enzyme -1.42783 24.0 174
Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 Tbio Enzyme -2.10178 116.1 292
Peroxisomal 2,4-dienoyl-CoA reductase DECR2 Tbio Enzyme -1.35266 22.3 112
Putative acyl-coenzyme A thioesterase 6 ACOT6 Tdark Enzyme 0.43 0.54 27
3-ketoacyl-CoA thiolase, peroxisomal ACAA1 Tbio Enzyme -2.31883 203.8 197
Acyl-coenzyme A thioesterase 8 ACOT8 Tbio Enzyme -2.41856 254.6 180