Development Level

Tbio 24 | 11,178
Tchem 8 | 1,885
Tclin 4 | 612
Tdark 1 | 6,569

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 2 | 278
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal pharyngeal arch morph... 1 | 8
abnormal retinal inner nuclear... 1 | 8
decreased blood urea nitrogen ... 1 | 51
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
hydrometra 1 | 53
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

group 3 medulloblastoma 21 | 4,002
ovarian cancer 21 | 8,297
Carcinoma 20 | 11,192
malignant mesothelioma 18 | 3,135
osteosarcoma 18 | 7,766
Cancer 16 | 2,388
lung cancer 16 | 4,607
psoriasis 16 | 6,514
medulloblastoma, large-cell 15 | 6,086
non-small cell lung cancer 12 | 2,799
atypical teratoid / rhabdoid tumor 11 | 4,971
glioblastoma 11 | 5,635
primitive neuroectodermal tumor 11 | 2,957
Breast cancer 8 | 3,469
Waldenstrons macroglobulinemia 8 | 742
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,204
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,902
oligodendroglioma 7 | 2,768
Autosomal recessive predisposition 6 | 1,407
Colorectal Neoplasms 6 | 235
diabetes mellitus 6 | 1,683
invasive ductal carcinoma 6 | 2,867
nasopharyngeal carcinoma 6 | 1,024
Multiple myeloma 5 | 1,296
Neurodegenerative disease 5 | 402
adult high grade glioma 5 | 3,701
ependymoma 5 | 4,559
lung adenocarcinoma 5 | 2,627
tuberculosis 5 | 1,963
Cockayne syndrome 4 | 59
Colonic Neoplasms 4 | 133
Kidney cancer 4 | 2,548
Lynch syndrome 4 | 34
Malignant tumor of ovary 4 | 25
Prostatic Neoplasms 4 | 472
Xeroderma pigmentosum 4 | 42
Xeroderma pigmentosum group G 4 | 16
adrenocortical carcinoma 4 | 1,385
astrocytic glioma 4 | 2,530
dermatomyositis 4 | 941
ductal carcinoma in situ 4 | 1,686
subependymal giant cell astrocytoma 4 | 2,230
Adenocarcinoma of lung 3 | 140
Bloom syndrome 3 | 29
Cerebrovascular disease 3 | 223
Chronic Lymphocytic Leukemia 3 | 254
Familial adenomatous polyposis 3 | 32
Intellectual disability 3 | 998
Kyphosis deformity of spine 3 | 112
Obesity 3 | 655
Short stature 3 | 514
Stomach Neoplasms 3 | 287
Xeroderma pigmentosum group D 3 | 32
acute myeloid leukemia 3 | 760
astrocytoma 3 | 1,113
breast carcinoma 3 | 1,589
Acute myeloid leukemia, disease 2 | 30
Adenocarcinoma 2 | 116
Adenoma 2 | 159
Alzheimer's disease 2 | 640
Arts syndrome 2 | 26
Atherosclerosis 2 | 276
Atrophy of cerebellum 2 | 101
Autistic Disorder 2 | 358
Bladder Neoplasm 2 | 106
Brain Injuries 2 | 63
Brain Ischemia 2 | 107
Broad forehead 2 | 58
Carcinoma in situ of fallopian tube 2 | 4
Cerebellar degeneration 2 | 101
Colorectal adenoma 2 | 15
Disease Models, Animal 2 | 148
Endometrial cancer 2 | 301
Endometriosis 2 | 521
Epilepsy 2 | 775
Heart disease 2 | 288
Immunologic Deficiency Syndromes 2 | 110
Infratentorial atrophy 2 | 101
Insulin Resistance 2 | 70
Lung Neoplasms 2 | 217
Malignant epithelial tumor of ovary 2 | 5
Malignant tumor of peritoneum 2 | 6
Melanoma 2 | 689
Nerve Degeneration 2 | 118
Parkinson's disease 2 | 378
Pick disease 2 | 1,856
Seckel syndrome 2 | 34
Seizures 2 | 584
Sensorineural Hearing Loss (disorder) 2 | 281
Urinary Bladder Neoplasms 2 | 108
atypical teratoid/rhabdoid tumor 2 | 349
colon cancer 2 | 1,428
gastric carcinoma 2 | 781
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,872
juvenile dermatomyositis 2 | 1,147
pediatric high grade glioma 2 | 1,035
pituitary cancer 2 | 1,915
primary Sjogren syndrome 2 | 710
spina bifida 2 | 1,053
ulcerative colitis 2 | 1,765

Tissue

Blood and immune system 37 | 16,909
Cardiovascular System 37 | 15,192
Digestive Tract 37 | 17,369
Endocrine System 37 | 18,159
Female tissues 37 | 17,400
Liver and Pancreas 37 | 16,750
Male tissues 37 | 17,142
Nervous System 37 | 16,725
Respiratory system 37 | 16,393
Skin and soft tissues 37 | 17,230
Urinary Tract 37 | 16,678

Target Family

Enzyme 26 | 4,145
Non-IDG 10 | 12,091
Transcription Factor 1 | 1,400

Reactome Pathway

Base Excision Repair 37 | 37
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methyl-CpG-binding domain protein 4 MBD4 Tbio Transcription Factor -1.99625 98.6 183
Poly [ADP-ribose] polymerase 2 PARP2 Tclin Enzyme -2.04657 95.2 212
DNA repair protein XRCC1 XRCC1 Tbio Non-IDG -2.99664 1034.1 418
G/T mismatch-specific thymine DNA glycosylase TDG Tbio Enzyme -2.46252 297.6 225
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Adenine DNA glycosylase MUTYH Tbio Enzyme -2.86910 750.8 255
Poly(ADP-ribose) glycohydrolase PARG Tchem Enzyme -2.32776 229.4 126
Endonuclease III-like protein 1 NTHL1 Tbio Enzyme -1.85066 66.8 155
Uracil-DNA glycosylase UNG Tbio Enzyme -2.82957 680.9 352
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171