Development Level

Tbio 42 | 11,445
Tdark 11 | 6,588
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 2 | 239
abnormal behavior 1 | 298
abnormal posture 1 | 2
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
embryonic lethality prior to t... 1 | 278
increased circulating free fat... 1 | 20

Disease

ovarian cancer 30 | 8,520
Carcinoma 26 | 11,493
psoriasis 23 | 6,694
lung cancer 22 | 4,740
osteosarcoma 19 | 7,950
Breast cancer 18 | 3,578
lung adenocarcinoma 14 | 2,716
Multiple myeloma 13 | 1,332
invasive ductal carcinoma 13 | 2,951
Cancer 12 | 2,499
ductal carcinoma in situ 11 | 1,745
glioblastoma 11 | 5,792
group 3 medulloblastoma 11 | 4,104
medulloblastoma, large-cell 11 | 6,241
non-small cell lung cancer 11 | 2,890
atypical teratoid / rhabdoid tumor 10 | 5,112
breast carcinoma 10 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Kidney cancer 9 | 2,613
malignant mesothelioma 9 | 3,232
colon cancer 8 | 1,478
ependymoma 8 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
group 4 medulloblastoma 7 | 1,855
oligodendroglioma 7 | 2,850
pancreatic cancer 7 | 2,398
primitive neuroectodermal tumor 7 | 3,035
Cleft Palate 6 | 271
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
spina bifida 6 | 1,074
Breast Neoplasms 5 | 445
Broad flat nasal bridge 5 | 236
Intellectual disability 5 | 1,016
Nasal bridge wide 5 | 236
Schizophrenia 5 | 1,160
Strabismus 5 | 270
Waldenstrons macroglobulinemia 5 | 765
astrocytic glioma 5 | 2,597
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
pediatric high grade glioma 5 | 1,064
Decreased projection of maxilla 4 | 66
Deficiency of upper jaw bones 4 | 66
Downward slant of palpebral fissure 4 | 158
Dull intelligence 4 | 645
Hypoplasia of the maxilla 4 | 66
Hypotrophic maxilla 4 | 66
Low Vision 4 | 174
Low intelligence 4 | 645
Mammary Neoplasms 4 | 425
Maxillary retrognathia 4 | 66
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Pick disease 4 | 1,894
Poor school performance 4 | 645
Retrusion of upper jaw bones 4 | 66
Rheumatoid arthritis 4 | 1,191
Small head 4 | 374
Treacher Collins syndrome 4 | 27
Visual Impairment 4 | 174
acute myeloid leukemia 4 | 783
astrocytoma 4 | 1,146
nasopharyngeal carcinoma 4 | 1,058
non-small cell lung carcinoma 4 | 317
sonic hedgehog group medulloblastoma 4 | 467
Adenocarcinoma of lung 3 | 142
Autistic Disorder 3 | 364
Bipolar Disorder 3 | 666
Cockayne syndrome 3 | 60
Congenital small ears 3 | 48
Connective tissue disease 3 | 62
Dementia 3 | 175
Depressive disorder 3 | 409
Disease Models, Animal 3 | 155
Epilepsy 3 | 792
Frontal bossing 3 | 157
Hereditary spherocytosis type 5 3 | 12
Lupus erythematosus 3 | 57
Malocclusion 3 | 57
Open Bite 3 | 21
Retrognathia 3 | 54
Seizures 3 | 596
Short stature 3 | 531
Tremor 3 | 113
Uranostaphyloschisis 3 | 167
acute quadriplegic myopathy 3 | 1,158
adult high grade glioma 3 | 3,801
gastric cancer 3 | 459
lung carcinoma 3 | 2,843
pancreatic carcinoma 3 | 562
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 468
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010

Tissue

Endocrine System 55 | 18,159
Blood and immune system 54 | 16,909
Digestive Tract 54 | 17,369
Female tissues 54 | 17,400
Skin and soft tissues 54 | 17,230
Cardiovascular System 53 | 15,192
Liver and Pancreas 53 | 16,750
Male tissues 53 | 17,142
Nervous System 53 | 16,725
Respiratory system 53 | 16,393
Urinary Tract 53 | 16,678

Target Family

Non-IDG 34 | 12,091
Enzyme 18 | 4,145
Epigenetic 4 | 242
Kinase 1 | 634

Reactome Pathway

B-WICH complex positively regu... 57 | 57
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A.J H2AFJ Tdark Non-IDG -0.00172 0.83 99
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Tyrosine-protein kinase BAZ1B BAZ1B Tbio Epigenetic -1.45627 32.0 155
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 16
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.27041 18.5 133
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88