Development Level

Tbio 326 | 10,625
Tchem 138 | 1,890
Tclin 69 | 602
Tdark 9 | 7,003

Collection

Eligible Ion Channel Proteins 7 | 117
Eligible Kinase Proteins 7 | 134

IMPC Term

preweaning lethality, complete... 24 | 633
decreased body weight 13 | 174
decreased total body fat amoun... 11 | 186
abnormal bone structure 8 | 131
decreased bone mineral content 8 | 157
abnormal behavior 6 | 226
abnormal retina morphology 6 | 100
decreased circulating fructosa... 6 | 31
decreased lean body mass 6 | 195
decreased lumbar vertebrae num... 6 | 62
embryonic lethality prior to t... 6 | 187
abnormal coat/hair pigmentatio... 5 | 54
decreased circulating serum al... 5 | 79
decreased circulating triglyce... 5 | 83
enlarged heart 5 | 111
increased circulating alkaline... 5 | 119
male infertility 5 | 62
abnormal embryo size 4 | 112
abnormal lens morphology 4 | 73
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased circulating choleste... 4 | 85
decreased circulating total pr... 4 | 41
decreased grip strength 4 | 123
decreased heart weight 4 | 44
decreased rib number 4 | 59
increased body weight 4 | 42
increased mean corpuscular hem... 4 | 93
short tibia 4 | 82
abnormal cornea morphology 3 | 24
abnormal locomotor activation 3 | 26
abnormal retinal pigmentation 3 | 61
abnormal seminal vesicle morph... 3 | 47
abnormal spleen morphology 3 | 36
cataract 3 | 26
corneal opacity 3 | 25
decreased body length 3 | 108
decreased caudal vertebrae num... 3 | 49
decreased circulating creatini... 3 | 31
decreased circulating glucose ... 3 | 121
decreased circulating iron lev... 3 | 25
decreased kidney weight 3 | 7
decreased mean corpuscular vol... 3 | 50
female infertility 3 | 34
impaired pupillary reflex 3 | 14
impaired righting response 3 | 19
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating phosphat... 3 | 24
increased fasted circulating g... 3 | 68
increased lean body mass 3 | 107
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
increased sacral vertebrae num... 3 | 62
increased startle reflex 3 | 38
irregularly shaped pupil 3 | 7
persistence of hyaloid vascula... 3 | 22
prenatal lethality prior to he... 3 | 64
preweaning lethality, incomple... 3 | 260
thrombocytopenia 3 | 46
abnormal bone mineralization 2 | 55
abnormal femur morphology 2 | 14
abnormal gait 2 | 51
abnormal iris morphology 2 | 12
abnormal kidney morphology 2 | 30
abnormal rib morphology 2 | 28
absent pinna reflex 2 | 21
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating potassiu... 2 | 17
decreased circulating sodium l... 2 | 18
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
decreased lactate dehydrogenas... 2 | 14
decreased leukocyte cell numbe... 2 | 54
decreased neutrophil cell numb... 2 | 37
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
edema 2 | 11
fused cornea and lens 2 | 4
hemorrhage 2 | 12
hypoactivity 2 | 89
increased bone mineral content 2 | 92
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating free fat... 2 | 17
increased circulating triglyce... 2 | 24
increased grip strength 2 | 83
increased hemoglobin content 2 | 45
increased rib number 2 | 41
limb grasping 2 | 35
tremors 2 | 34
vertebral fusion 2 | 23
abnormal neural tube closure 1 | 37
decreased circulating chloride... 1 | 32
decreased effector memory CD8-... 1 | 24
decreased mean corpuscular hem... 1 | 34
long tibia 1 | 13
prenatal lethality 1 | 16

Disease

ovarian cancer 313 | 8,484
osteosarcoma 286 | 7,933
glioblastoma 271 | 5,572
medulloblastoma, large-cell 248 | 6,234
psoriasis 244 | 6,685
lung cancer 207 | 4,466
atypical teratoid / rhabdoid tumor 202 | 4,369
Cancer 184 | 2,346
pilocytic astrocytoma 171 | 3,086
Carcinoma 163 | 2,147
oligodendroglioma 155 | 2,849
Breast cancer 153 | 3,094
malignant mesothelioma 149 | 3,162
pediatric high grade glioma 149 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 141 | 3,289
invasive ductal carcinoma 141 | 2,950
lung carcinoma 133 | 2,844
primitive neuroectodermal tumor 126 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 119 | 2,956
lung adenocarcinoma 119 | 2,713
subependymal giant cell astrocytoma 119 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 117 | 2,988
pancreatic cancer 115 | 2,300
ependymoma 114 | 2,514
astrocytic glioma 111 | 2,241
interstitial cystitis 108 | 2,299
non-small cell lung cancer 104 | 2,798
pituitary cancer 98 | 1,972
ulcerative colitis 93 | 2,087
Pick disease 88 | 1,893
cystic fibrosis 86 | 1,665
group 4 medulloblastoma 82 | 1,875
ductal carcinoma in situ 80 | 1,745
astrocytoma 78 | 1,493
primary pancreatic ductal adenocarcinoma 77 | 1,271
breast carcinoma 73 | 1,614
group 3 medulloblastoma 73 | 2,254
adult high grade glioma 70 | 2,148
posterior fossa group A ependymoma 70 | 1,511
Multiple myeloma 69 | 1,327
colon cancer 69 | 1,475
medulloblastoma 66 | 1,524
diabetes mellitus 64 | 1,663
sonic hedgehog group medulloblastoma 62 | 1,482
tuberculosis 61 | 1,557
posterior fossa group B ependymoma 57 | 1,530
juvenile dermatomyositis 56 | 1,189
Rheumatoid Arthritis 54 | 1,160
Alzheimer's disease 50 | 644
dermatomyositis 49 | 933
Waldenstrons macroglobulinemia 47 | 765
cutaneous lupus erythematosus 47 | 1,056
gastric carcinoma 45 | 832
adrenocortical carcinoma 44 | 1,427
Schizophrenia 43 | 501
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,795
Intellectual disability 40 | 573
atypical teratoid/rhabdoid tumor 40 | 1,095
acute quadriplegic myopathy 39 | 1,157
spina bifida 38 | 1,064
Down syndrome 36 | 548
Duchenne muscular dystrophy 36 | 602
Mammary Neoplasms 35 | 410
non-small cell lung carcinoma 34 | 413
Atopic dermatitis 33 | 944
Parkinson's disease 33 | 364
primary Sjogren syndrome 33 | 789
Autistic Disorder 32 | 320
Epilepsy 31 | 346
Prostatic Neoplasms 30 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 30 | 499
esophageal adenocarcinoma 30 | 737
nasopharyngeal carcinoma 30 | 1,056
non primary Sjogren syndrome sicca 28 | 840
pancreatic carcinoma 28 | 567
Multiple Sclerosis 27 | 498
Kidney disease 25 | 396
active Crohn's disease 25 | 918
progressive supranuclear palsy 25 | 674
Amyotrophic Lateral Sclerosis 24 | 431
Heart disease 24 | 279
Vascular disease 24 | 281
Lung Neoplasms 23 | 171
Neoplasm Invasiveness 23 | 127
Renal Cell Carcinoma 23 | 199
fibroadenoma 23 | 557
mucosa-associated lymphoid tissue lymphoma 23 | 480
Liver carcinoma 22 | 217
Blastic phase chronic myeloid leukemia 21 | 58
Chronic Myelocytic Leukemia Accelerated Phase 21 | 59
HIV Infections 21 | 100
IGA Glomerulonephritis 21 | 454
Obesity 21 | 616
acute myeloid leukemia 21 | 780
interstitial lung disease 21 | 291
tuberculosis and treatment for 6 months 21 | 686
Mammary Neoplasms, Experimental 20 | 150
Osteoporosis 20 | 257
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 20 | 45
aldosterone-producing adenoma 20 | 664

Tissue

Endocrine System 541 | 18,512
Female tissues 541 | 18,647
Nervous System 541 | 18,561
Digestive Tract 540 | 18,473
Urinary Tract 540 | 18,444
Liver and Pancreas 538 | 18,136
Blood and immune system 537 | 17,995
Cardiovascular System 537 | 17,958
Male tissues 536 | 17,969
Skin and soft tissues 535 | 18,115
Respiratory system 527 | 17,484

Target Family

Non-IDG 291 | 11,971
Enzyme 122 | 4,146
Kinase 91 | 634
Ion Channel 37 | 341
Transcription Factor 1 | 1,400

Reactome Pathway

Axon guidance 542 | 542
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Contactin-6 CNTN6 Tbio Non-IDG -2.02527 101.3 65
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.54485 39.7 163
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169