Development Level

Tbio 396 | 11,651
Tchem 76 | 1,388
Tclin 46 | 612
Tdark 15 | 6,593

Collection

RFA-RM-18-021 14 | 328
Ion Channel: IDG Consortium (T... 7 | 99
Kinase: IDG Consortium (Target... 7 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 34 | 979
decreased body weight 9 | 161
embryonic lethality prior to t... 9 | 278
preweaning lethality, incomple... 9 | 499
decreased total body fat amoun... 8 | 207
abnormal bone structure 7 | 187
edema 6 | 59
embryonic lethality prior to o... 6 | 239
short tibia 6 | 97
abnormal behavior 5 | 298
abnormal embryo size 5 | 220
abnormal retina morphology 5 | 71
decreased vertical activity 5 | 208
embryonic growth retardation 5 | 106
increased circulating triglyce... 5 | 42
increased startle reflex 5 | 112
abnormal cornea morphology 4 | 31
abnormal gait 4 | 69
decreased circulating serum al... 4 | 82
decreased circulating total pr... 4 | 49
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular vol... 4 | 79
increased circulating alkaline... 4 | 122
increased neutrophil cell numb... 4 | 46
persistence of hyaloid vascula... 4 | 33
prenatal lethality prior to he... 4 | 87
prolonged QT interval 4 | 38
abnormal coat-hair pigmentatio... 3 | 64
abnormal kidney morphology 3 | 65
abnormal locomotor activation 3 | 16
abnormal spleen morphology 3 | 55
cataract 3 | 92
decreased bone mineral content 3 | 151
decreased caudal vertebrae num... 3 | 53
decreased circulating amylase ... 3 | 28
decreased circulating creatini... 3 | 39
decreased circulating fructosa... 3 | 30
decreased grip strength 3 | 116
decreased hematocrit 3 | 46
enlarged heart 3 | 210
hemorrhage 3 | 23
hydrometra 3 | 53
hypoactivity 3 | 132
impaired pupillary reflex 3 | 26
increased blood urea nitrogen ... 3 | 48
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
increased or absent threshold ... 3 | 101
abnormal femur morphology 2 | 14
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal pericardium morpholog... 2 | 26
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
corneal opacity 2 | 32
cyanosis 2 | 7
decreased body length 2 | 101
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating iron lev... 2 | 32
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
enlarged kidney 2 | 14
enlarged uterus 2 | 11
fused cornea and lens 2 | 5
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased circulating amylase ... 2 | 25
increased circulating calcium ... 2 | 34
increased fasted circulating g... 2 | 76
increased hemoglobin content 2 | 45
increased red blood cell distr... 2 | 34
increased spleen weight 2 | 10
male infertility 2 | 123
pallor 2 | 34
prenatal lethality 2 | 28
prolonged PR interval 2 | 15
prolonged ST segment 2 | 36
respiratory system phenotype 2 | 2
small superior vagus ganglion 2 | 74
tremors 2 | 39
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal vocalization 1 | 21
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 342 | 11,493
ovarian cancer 300 | 8,520
glioblastoma 244 | 5,792
osteosarcoma 243 | 7,950
medulloblastoma, large-cell 224 | 6,241
psoriasis 215 | 6,694
lung cancer 211 | 4,740
atypical teratoid / rhabdoid tumor 203 | 5,112
ependymoma 172 | 4,679
Breast cancer 161 | 3,578
Kidney cancer 148 | 2,613
adult high grade glioma 147 | 3,801
Astrocytoma, Pilocytic 144 | 3,081
group 3 medulloblastoma 138 | 4,104
oligodendroglioma 138 | 2,850
Cancer 136 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 133 | 3,291
malignant mesothelioma 124 | 3,232
invasive ductal carcinoma 120 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 115 | 2,955
primitive neuroectodermal tumor 113 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 110 | 2,989
astrocytic glioma 108 | 2,597
lung carcinoma 108 | 2,843
subependymal giant cell astrocytoma 107 | 2,287
pancreatic cancer 100 | 2,398
non-small cell lung cancer 92 | 2,890
lung adenocarcinoma 89 | 2,716
Multiple myeloma 82 | 1,332
Pick disease 82 | 1,894
pituitary cancer 82 | 1,972
interstitial cystitis 78 | 2,312
Schizophrenia 75 | 1,160
cystic fibrosis 73 | 1,696
diabetes mellitus 73 | 1,728
group 4 medulloblastoma 69 | 1,855
breast carcinoma 68 | 1,638
ductal carcinoma in situ 64 | 1,745
astrocytoma 62 | 1,146
colon cancer 61 | 1,478
ulcerative colitis 60 | 1,819
Waldenstrons macroglobulinemia 56 | 765
primary pancreatic ductal adenocarcinoma 56 | 1,109
Intellectual disability 54 | 1,016
juvenile dermatomyositis 54 | 1,187
Epilepsy 52 | 792
Alzheimer's disease 51 | 658
Liver cancer 51 | 604
tuberculosis 51 | 2,010
acute quadriplegic myopathy 49 | 1,158
Autosomal recessive predisposition 48 | 1,442
dermatomyositis 47 | 966
pancreatic ductal adenocarcinoma liver metastasis 43 | 1,962
Bipolar Disorder 42 | 666
pediatric high grade glioma 41 | 1,064
Melanoma 39 | 711
Muscle hypotonia 38 | 571
adrenocortical carcinoma 38 | 1,428
cutaneous lupus erythematosus 38 | 1,057
Rheumatoid arthritis 37 | 1,191
Seizures 37 | 596
Skin cancer 35 | 469
Duchenne muscular dystrophy 34 | 601
medulloblastoma 34 | 720
spina bifida 33 | 1,074
Dull intelligence 32 | 645
Liver Cirrhosis, Experimental 32 | 769
Low intelligence 32 | 645
Mental Retardation 32 | 645
Mental deficiency 32 | 645
Poor school performance 32 | 645
gastric carcinoma 32 | 807
Autistic Disorder 31 | 364
Cognitive delay 31 | 608
Global developmental delay 31 | 608
Mental and motor retardation 31 | 608
Short stature 31 | 531
Down syndrome 30 | 499
Anemia 29 | 365
Atopic dermatitis 29 | 952
Breast Neoplasms 29 | 445
Mammary Neoplasms 28 | 425
Parkinson's disease 28 | 392
Cleft Palate 27 | 271
Stomach Neoplasms 27 | 300
acute myeloid leukemia 27 | 783
primary Sjogren syndrome 27 | 735
progressive supranuclear palsy 26 | 676
Amyotrophic lateral sclerosis 25 | 451
Diamond-Blackfan anemia 25 | 31
Endometrial cancer 25 | 311
Uranostaphyloschisis 25 | 167
autosomal dominant Emery-Dreifuss muscular dystrophy 25 | 510
sonic hedgehog group medulloblastoma 25 | 467
Multiple Sclerosis 24 | 540
Prostatic Neoplasms 24 | 495
nasopharyngeal carcinoma 24 | 1,058
Mandibular hypoplasia 23 | 275
Micrognathism 23 | 275
non primary Sjogren syndrome sicca 23 | 891

Tissue

Endocrine System 526 | 18,159
Digestive Tract 513 | 17,369
Female tissues 512 | 17,400
Nervous System 512 | 16,725
Male tissues 510 | 17,142
Skin and soft tissues 510 | 17,230
Blood and immune system 507 | 16,909
Liver and Pancreas 506 | 16,750
Urinary Tract 502 | 16,678
Respiratory system 501 | 16,393
Cardiovascular System 486 | 15,192

Target Family

Non-IDG 324 | 12,091
Enzyme 97 | 4,145
Kinase 70 | 634
Ion Channel 34 | 344
Transcription Factor 7 | 1,400
GPCR 1 | 408

Reactome Pathway

Axon guidance 533 | 533
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
60S ribosomal protein L17 RPL17 Tbio Non-IDG -1.22337 16.5 217
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Ephrin type-A receptor 6 EPHA6 Tchem Kinase -1.34848 21.8 266
Sodium channel protein type 2 subunit alpha SCN2A Tclin Ion Channel -3.11580 1268.8 107
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Spectrin beta chain, non-erythrocytic 5 SPTBN5 Tbio Non-IDG -0.41365 2.99 32
Integrin alpha-9 ITGA9 Tbio Non-IDG -1.46619 29.0 124
LIM domain kinase 2 LIMK2 Tchem Kinase -1.65006 41.3 405