Development Level

Tbio 54 | 11,445
Tclin 5 | 613
Tdark 3 | 6,588
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased vertical activity 3 | 208
abnormal eye morphology 2 | 68
decreased circulating choleste... 2 | 93
decreased circulating total pr... 2 | 49
decreased lean body mass 2 | 135
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
impaired glucose tolerance 2 | 75
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye size 1 | 7
abnormal eyelid morphology 1 | 7
abnormal head size 1 | 6
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placement of pupils 1 | 6
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal tail movements 1 | 12
corneal opacity 1 | 32
curly tail 1 | 1
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating serum al... 1 | 82
decreased hemoglobin content 1 | 68
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hydrometra 1 | 53
hydrops fetalis 1 | 1
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating insulin ... 1 | 3
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
kinked tail 1 | 2
mammalian phenotype 1 | 17
microphthalmia 1 | 26
narrow eye opening 1 | 12
pale yolk sac 1 | 25
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

ovarian cancer 45 | 8,520
lung cancer 30 | 4,740
Carcinoma 28 | 11,493
psoriasis 28 | 6,694
Multiple myeloma 27 | 1,332
osteosarcoma 25 | 7,950
glioblastoma 22 | 5,792
Breast cancer 16 | 3,578
ependymoma 16 | 4,679
HIV Infections 15 | 102
atypical teratoid / rhabdoid tumor 14 | 5,112
medulloblastoma, large-cell 13 | 6,241
non-small cell lung cancer 12 | 2,890
Cancer 11 | 2,499
group 3 medulloblastoma 11 | 4,104
dermatomyositis 10 | 966
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
tuberculosis 10 | 2,010
Astrocytoma, Pilocytic 9 | 3,081
Waldenstrons macroglobulinemia 9 | 765
astrocytic glioma 9 | 2,597
interstitial cystitis 9 | 2,312
subependymal giant cell astrocytoma 9 | 2,287
adult high grade glioma 8 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
invasive ductal carcinoma 8 | 2,951
malignant mesothelioma 8 | 3,232
oligodendroglioma 8 | 2,850
astrocytoma 7 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung adenocarcinoma 7 | 2,716
lung carcinoma 7 | 2,843
non primary Sjogren syndrome sicca 7 | 891
Pick disease 6 | 1,894
acute myeloid leukemia 6 | 783
Liver Cirrhosis, Experimental 5 | 769
Mantle cell lymphoma 5 | 23
breast carcinoma 5 | 1,638
cystic fibrosis 5 | 1,696
diabetes mellitus 5 | 1,728
pancreatic cancer 5 | 2,398
pituitary cancer 5 | 1,972
primitive neuroectodermal tumor 5 | 3,035
Kidney cancer 4 | 2,613
Osteoporosis 4 | 363
active Crohn's disease 4 | 922
cutaneous lupus erythematosus 4 | 1,057
ductal carcinoma in situ 4 | 1,745
primary Sjogren syndrome 4 | 735
primary pancreatic ductal adenocarcinoma 4 | 1,109
ulcerative colitis 4 | 1,819
Anemia 3 | 365
Rheumatoid arthritis 3 | 1,191
Robinow syndrome 3 | 11
chronic kidney disease 3 | 90
esophageal adenocarcinoma 3 | 737
fibroadenoma 3 | 559
hepatocellular carcinoma 3 | 547
juvenile dermatomyositis 3 | 1,187
pediatric high grade glioma 3 | 1,064
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
Alzheimer's disease 2 | 658
Animal Mammary Neoplasms 2 | 136
Cleft Palate 2 | 271
Congenital hypoplasia of penis 2 | 176
Congestive heart failure 2 | 113
Epilepsy 2 | 792
Esophageal Squamous Cell Carcinoma 2 | 77
Frontal bossing 2 | 157
Gingival Hyperplasia 2 | 34
Gingival Hypertrophy 2 | 34
Gingival Overgrowth 2 | 36
Hydrolethalus syndrome 2 | 128
Hypoplastic mandible condyle 2 | 275
Hypotrophic malar bone 2 | 129
Intellectual disability 2 | 1,016
Long philtrum 2 | 137
Macroglossia 2 | 65
Malar flattening 2 | 129
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Mandibular hypoplasia 2 | 275
Micrognathism 2 | 275
Myofibrillar myopathy 1 2 | 6
Norrie disease 2 | 14
Orbital separation excessive 2 | 244
Pick's disease 2 | 15
Squamous cell carcinoma of esophagus 2 | 77
Syndactyly 2 | 88
Vascular disease 2 | 319
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
colon cancer 2 | 1,478
gastric cancer 2 | 459
gastric carcinoma 2 | 807
glioblastoma multiforme 2 | 142
group 4 medulloblastoma 2 | 1,855
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Endocrine System 63 | 18,159
Blood and immune system 62 | 16,909
Digestive Tract 62 | 17,369
Female tissues 62 | 17,400
Male tissues 62 | 17,142
Nervous System 62 | 16,725
Respiratory system 62 | 16,393
Urinary Tract 62 | 16,678
Cardiovascular System 61 | 15,192
Liver and Pancreas 61 | 16,750
Skin and soft tissues 61 | 17,230

Target Family

Enzyme 41 | 4,145
Non-IDG 16 | 12,091
GPCR 7 | 408

Reactome Pathway

Asymmetric localization of PCP... 64 | 64
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Putative protein SEM1, isoform 2 SEM1 Tbio Non-IDG 0.30 0.49 109
Proteasome subunit alpha type-2 PSMA2 Tbio Enzyme -0.82346 5.78 245