Development Level

Tbio 34 | 10,625
Tchem 21 | 1,890
Tdark 2 | 7,003

IMPC Phenotype

abnormal femur morphology 2 | 14
decreased hemoglobin content 2 | 53
decreased total body fat amoun... 2 | 186
increased fasted circulating g... 2 | 68
short tibia 2 | 82
abnormal QRS complex 1 | 25
abnormal ear morphology 1 | 5
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal pelvic girdle bone mo... 1 | 11
abnormal radius morphology 1 | 8
abnormal skin morphology 1 | 23
abnormal sleep behavior 1 | 63
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
convulsive seizures 1 | 11
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased body length 1 | 108
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased threshold for audito... 1 | 32
dilated heart left ventricle 1 | 10
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating phosphat... 1 | 24
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased or absent threshold ... 1 | 128
increased vertical activity 1 | 18
irregularly shaped pupil 1 | 7
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
preweaning lethality, complete... 1 | 633

Disease

ovarian cancer 38 | 8,491
glioblastoma 32 | 5,572
lung cancer 32 | 4,473
Carcinoma 31 | 2,147
pilocytic astrocytoma 31 | 3,086
Breast cancer 30 | 3,098
atypical teratoid / rhabdoid tumor 29 | 4,369
pancreatic cancer 29 | 2,300
interstitial cystitis 27 | 2,299
malignant mesothelioma 27 | 3,163
non-small cell lung cancer 27 | 2,798
psoriasis 27 | 6,685
lung adenocarcinoma 26 | 2,714
pediatric high grade glioma 26 | 2,712
medulloblastoma, large-cell 25 | 6,234
posterior fossa group A ependymoma 25 | 1,511
primary pancreatic ductal adenocarcinoma 24 | 1,271
osteosarcoma 23 | 7,933
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
ulcerative colitis 22 | 2,087
gastric carcinoma 21 | 832
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,289
invasive ductal carcinoma 20 | 2,950
breast carcinoma 19 | 1,614
cystic fibrosis 19 | 1,670
pituitary cancer 19 | 1,972
Duchenne muscular dystrophy 18 | 602
lung carcinoma 18 | 2,844
primitive neuroectodermal tumor 18 | 3,031
esophageal adenocarcinoma 16 | 737
juvenile dermatomyositis 15 | 1,189
nasopharyngeal carcinoma 15 | 1,056
sonic hedgehog group medulloblastoma 15 | 1,482
Cancer 14 | 2,346
urothelial carcinoma 13 | 318
Becker muscular dystrophy 12 | 187
ductal carcinoma in situ 12 | 1,745
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
colon cancer 11 | 1,475
interstitial lung disease 11 | 292
oligodendroglioma 11 | 2,849
Spontaneous abortion 10 | 108
active Crohn's disease 10 | 918
primary Sjogren syndrome 10 | 788
subependymal giant cell astrocytoma 10 | 2,287
Epidermolysis bullosa 9 | 21
Osteoarthritis 9 | 96
Pick disease 9 | 1,893
cutaneous lupus erythematosus 9 | 1,056
head and neck cancer and chronic obstructive pulmonary disease 9 | 237
limb girdle muscular dystrophy 2A 9 | 156
Atopic dermatitis 8 | 944
Kidney disease 8 | 397
adrenocortical carcinoma 8 | 1,427
astrocytoma 8 | 1,493
periodontitis 8 | 269
pterygium 8 | 74
tuberculosis 8 | 1,563
Ehlers-Danlos syndrome 7 | 42
Stickler syndrome 7 | 13
diabetes mellitus 7 | 1,663
ependymoma 7 | 2,514
Alport syndrome 6 | 21
Arthritis 6 | 248
Myopia 6 | 99
dermatomyositis 6 | 966
fibroadenoma 6 | 557
glioblastoma multiforme 6 | 347
group 3 medulloblastoma 6 | 2,254
inflammatory breast cancer 6 | 404
Atherosclerosis 5 | 275
Cataract 5 | 104
Degenerative disc disease 5 | 28
Keratoconus 5 | 49
Neoplasm Invasiveness 5 | 127
Osteogenesis imperfecta 5 | 34
Posterior polymorphous corneal dystrophy 5 | 24
Sensorineural hearing loss 5 | 107
Vascular disease 5 | 281
acute quadriplegic myopathy 5 | 1,157
astrocytic glioma 5 | 2,241
group 4 medulloblastoma 5 | 1,875
head and neck cancer 5 | 270
medulloblastoma 5 | 1,524
non-small cell lung carcinoma 5 | 413
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Barrett's esophagus 4 | 185
Cleft palate 4 | 125
Craniofacial Abnormalities 4 | 147
Down syndrome 4 | 548
Fibrochondrogenesis 4 | 8
Glaucoma 4 | 135
Junctional epidermolysis bullosa 4 | 9
Mammary Neoplasms 4 | 410
Muscular dystrophy 4 | 48
Osteoporosis 4 | 259
mucosa-associated lymphoid tissue lymphoma 4 | 480
nephrosclerosis 4 | 329
progressive supranuclear palsy 4 | 674

Tissue

Digestive Tract 57 | 18,472
Endocrine System 57 | 18,511
Female tissues 57 | 18,646
Male tissues 57 | 17,968
Skin and soft tissues 57 | 18,114
Urinary Tract 57 | 18,443
Blood and immune system 56 | 17,994
Cardiovascular System 56 | 17,957
Nervous System 56 | 18,560
Respiratory system 56 | 17,483
Liver and Pancreas 55 | 18,135

Target Family

Non-IDG 43 | 11,969
Enzyme 14 | 4,146

Reactome Pathway

Assembly of collagen fibrils a... 57 | 57
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Collagen alpha-1(VIII) chain COL8A1 Tbio Non-IDG -1.25305 16.3 98
Collagen alpha-1(I) chain COL1A1 Tbio Non-IDG -2.94271 807.7 451
Collagen alpha-1(IV) chain COL4A1 Tchem Non-IDG -2.25341 170.3 323
Collagen alpha-1(III) chain COL3A1 Tchem Non-IDG -2.54818 328.8 384
Collagen alpha-1(II) chain COL2A1 Tbio Non-IDG -2.86562 689.3 377
Collagen alpha-3(IV) chain COL4A3 Tbio Non-IDG -2.30033 190.3 198
Collagen alpha-1(X) chain COL10A1 Tbio Non-IDG -2.13012 122.2 58
Collagen alpha-1(IX) chain COL9A1 Tbio Non-IDG -1.57652 36.6 86
Cathepsin B CTSB Tchem Enzyme -3.65774 4405.5 400
Collagen alpha-1(VII) chain COL7A1 Tbio Non-IDG -2.55582 363.5 81