Development Level

Tbio 47 | 11,651
Tchem 8 | 1,388
Tdark 2 | 6,593

IMPC Phenotype

abnormal femur morphology 2 | 14
decreased total body fat amoun... 2 | 207
increased fasted circulating g... 2 | 76
short tibia 2 | 97
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
dilated heart left ventricle 1 | 11
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased vertical activity 1 | 24
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 52 | 11,493
ovarian cancer 38 | 8,520
Breast cancer 37 | 3,578
glioblastoma 35 | 5,792
Astrocytoma, Pilocytic 32 | 3,081
lung cancer 32 | 4,740
pancreatic cancer 31 | 2,398
Kidney cancer 30 | 2,613
atypical teratoid / rhabdoid tumor 30 | 5,112
ependymoma 30 | 4,679
non-small cell lung cancer 28 | 2,890
psoriasis 28 | 6,694
interstitial cystitis 27 | 2,312
malignant mesothelioma 27 | 3,232
lung adenocarcinoma 26 | 2,716
Autosomal recessive predisposition 25 | 1,442
medulloblastoma, large-cell 24 | 6,241
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
gastric carcinoma 22 | 807
osteosarcoma 22 | 7,950
adult high grade glioma 21 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
invasive ductal carcinoma 20 | 2,951
pituitary cancer 20 | 1,972
ulcerative colitis 20 | 1,819
Duchenne muscular dystrophy 19 | 601
breast carcinoma 19 | 1,638
cystic fibrosis 19 | 1,696
primitive neuroectodermal tumor 19 | 3,035
esophageal adenocarcinoma 17 | 737
lung carcinoma 17 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
juvenile dermatomyositis 16 | 1,187
nasopharyngeal carcinoma 16 | 1,058
Cancer 15 | 2,499
Liver Cirrhosis, Experimental 15 | 769
Short stature 15 | 531
group 3 medulloblastoma 14 | 4,104
Degenerative polyarthritis 13 | 115
Myopia 13 | 176
Skin cancer 13 | 469
primary pancreatic ductal adenocarcinoma 13 | 1,109
urothelial carcinoma 13 | 318
Atrophic scar 12 | 18
Becker muscular dystrophy 12 | 191
Melanoma 12 | 711
ductal carcinoma in situ 12 | 1,745
interstitial lung disease 12 | 298
oligodendroglioma 12 | 2,850
Cataract 11 | 297
Liver cancer 11 | 604
Osteoarthritis 11 | 184
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
colon cancer 11 | 1,478
limb girdle muscular dystrophy 2A 11 | 213
Abortion, Spontaneous 10 | 109
Acquired scoliosis 10 | 281
Curvature of spine 10 | 282
Dental caries 10 | 164
Hypoplastic mandible condyle 10 | 275
Joint hyperflexibility 10 | 78
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
Platyspondyly 10 | 56
Spontaneous abortion 10 | 113
subependymal giant cell astrocytoma 10 | 2,287
Epidermolysis bullosa 9 | 21
Pick disease 9 | 1,894
Rotting teeth 9 | 73
Sensorineural Hearing Loss (disorder) 9 | 284
active Crohn's disease 9 | 922
cutaneous lupus erythematosus 9 | 1,057
head and neck cancer and chronic obstructive pulmonary disease 9 | 239
periodontitis 9 | 293
tuberculosis 9 | 2,010
Atopic dermatitis 8 | 952
Contracture 8 | 96
Contracture of joint 8 | 93
Degenerative disc disease 8 | 35
Dystrophia unguium 8 | 53
Failure to gain weight 8 | 365
Flexion contracture 8 | 93
Flexion contractures of joints 8 | 93
Fragile skin 8 | 18
Hypotrophic malar bone 8 | 129
Kidney disease 8 | 430
Lens Opacities 8 | 231
Malar flattening 8 | 129
Pediatric failure to thrive 8 | 365
Premature Birth 8 | 77
adrenocortical carcinoma 8 | 1,428
astrocytic glioma 8 | 2,597
group 4 medulloblastoma 8 | 1,855
pediatric high grade glioma 8 | 1,064
pterygium 8 | 76
Liver Cirrhosis 7 | 181
dermatomyositis 7 | 966
diabetes mellitus 7 | 1,728
medulloblastoma 7 | 720

Tissue

Digestive Tract 57 | 17,369
Endocrine System 57 | 18,159
Female tissues 57 | 17,400
Blood and immune system 56 | 16,909
Male tissues 56 | 17,142
Skin and soft tissues 55 | 17,230
Urinary Tract 55 | 16,678
Liver and Pancreas 54 | 16,750
Nervous System 53 | 16,725
Respiratory system 53 | 16,393
Cardiovascular System 51 | 15,192

Target Family

Non-IDG 43 | 12,091
Enzyme 14 | 4,145

Reactome Pathway

Assembly of collagen fibrils a... 57 | 57
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Laminin subunit gamma-2 LAMC2 Tbio Non-IDG -2.09168 112.5 175
Laminin subunit beta-3 LAMB3 Tbio Non-IDG -2.07156 116.4 170
Tolloid-like protein 2 TLL2 Tbio Non-IDG -1.00652 6.10 35
Protein-lysine 6-oxidase LOX Tbio Enzyme -3.36257 2227.1 513
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.24186 173.0 274
Collagen alpha-1(III) chain COL3A1 Tbio Non-IDG -2.58251 354.8 439
Collagen alpha-3(IV) chain COL4A3 Tbio Non-IDG -2.32017 204.4 209
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.96102 8811.6 1442
Collagen alpha-1(II) chain COL2A1 Tbio Non-IDG -2.89229 724.4 424
Collagen alpha-1(I) chain COL1A1 Tbio Non-IDG -2.98303 874.8 508