Development Level

Tbio 11 | 11,445
Tchem 6 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal body wall morphology 1 | 9
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal neural tube closure 1 | 46
abnormal tail morphology 1 | 25
abnormal vibrissa morphology 1 | 25
absent optic nerve 1 | 2
brachydactyly 1 | 19
cleft palate 1 | 8
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
decreased granulocyte number 1 | 6
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
increased B cell number 1 | 9
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating serum al... 1 | 22
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
thrombocytopenia 1 | 56

Disease

Carcinoma 10 | 11,493
psoriasis 10 | 6,694
osteosarcoma 8 | 7,950
Obesity 7 | 678
diabetes mellitus 7 | 1,728
Atherosclerosis 6 | 291
Coronary artery disease 6 | 268
Lipid metabolism disorder 6 | 114
breast carcinoma 6 | 1,638
ductal carcinoma in situ 6 | 1,745
invasive ductal carcinoma 6 | 2,951
lung cancer 6 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Cardiovascular system disease 5 | 246
Pancreatitis 5 | 123
fibroadenoma 5 | 559
glioblastoma 5 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
medulloblastoma, large-cell 5 | 6,241
ovarian cancer 5 | 8,520
Cancer 4 | 2,499
Hypertriglyceridemia 4 | 17
group 3 medulloblastoma 4 | 4,104
malignant mesothelioma 4 | 3,232
Atopic dermatitis 3 | 952
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Eruptive xanthoma 3 | 3
Familial hyperlipidemia 3 | 6
Hypercholesterolemia, Familial 3 | 23
Hyperlipoproteinemia Type II 3 | 12
Hyperlipoproteinemia Type V 3 | 3
Vascular disease 3 | 319
atypical teratoid / rhabdoid tumor 3 | 5,112
lung carcinoma 3 | 2,843
nasopharyngeal carcinoma 3 | 1,058
pituitary cancer 3 | 1,972
primitive neuroectodermal tumor 3 | 3,035
Acquired metabolic disease 2 | 336
Amyloidosis 2 | 67
Amyotrophic lateral sclerosis 2 | 451
Animal Mammary Neoplasms 2 | 136
Astrocytoma, Pilocytic 2 | 3,081
Carcinoma, Hepatocellular 2 | 228
Chylomicron retention disease 2 | 11
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Dyslipidemias 2 | 27
Fatty Liver 2 | 70
Fatty liver disease 2 | 103
Hyperglycemia 2 | 137
Hyperlipidemia 2 | 43
Hyperlipidemias 2 | 17
Hyperlipoproteinemia Type I 2 | 2
Hypertriglyceridemia result 2 | 37
Lipidemia retinalis 2 | 4
Liver Cirrhosis, Experimental 2 | 769
Liver Neoplasms, Experimental 2 | 59
Liver carcinoma 2 | 240
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Metabolic syndrome X 2 | 52
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
Splenomegaly 2 | 190
Type 2 diabetes mellitus 2 | 272
adult high grade glioma 2 | 3,801
astrocytoma 2 | 1,146
dermatomyositis 2 | 966
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung adenocarcinoma 2 | 2,716
mucosa-associated lymphoid tissue lymphoma 2 | 484
non-small cell lung cancer 2 | 2,890
pediatric high grade glioma 2 | 1,064
posterior fossa group B ependymoma 2 | 416
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
Abnormal vertebral bodies 1 | 16
Absent eyebrow 1 | 13
Agenesis of eyebrows 1 | 13
Aplasia of eyebrows 1 | 13
Bone Diseases, Developmental 1 | 27
Congenital anomaly of spine 1 | 16
Convex nasal ridge 1 | 37
Dystrophic fingernails 1 | 18
Ectropion 1 | 38
Familial partial lipodystrophy 1 | 12
Heart Septal Defects, Ventricular 1 | 6
Hepatosplenomegaly 1 | 22
Jaw Abnormalities 1 | 5
Lipodystrophy 1 | 40
Lower Extremity Deformities, Congenital 1 | 2
Madarosis of eyebrow 1 | 13
Motion sickness 1 | 21
Multiple vertebral anomalies 1 | 16
Olivopontocerebellar Atrophies 1 | 6
Phrynoderma 1 | 11
Plagiocephaly 1 | 20

Tissue

Endocrine System 18 | 18,159
Liver and Pancreas 18 | 16,750
Digestive Tract 17 | 17,369
Female tissues 17 | 17,400
Skin and soft tissues 17 | 17,230
Blood and immune system 16 | 16,909
Urinary Tract 16 | 16,678
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Cardiovascular System 14 | 15,192

Target Family

Enzyme 9 | 4,145
Non-IDG 8 | 12,091
Transcription Factor 1 | 1,400

Reactome Pathway

Assembly of active LPL and LIP... 18 | 18
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lipase maturation factor 1 LMF1 Tbio Enzyme -1.30021 24.5 35
Lipase maturation factor 2 LMF2 Tdark Enzyme -0.22185 1.90 91
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 GPIHBP1 Tbio Non-IDG -1.82315 79.6 104
Apolipoprotein A-V APOA5 Tbio Non-IDG -2.58826 425.0 481
Proprotein convertase subtilisin/kexin type 5 PCSK5 Tchem Enzyme -2.88342 751.2 143
Fibroblast growth factor 21 FGF21 Tbio Non-IDG -2.81854 777.4 443
Cyclic AMP-responsive element-binding protein 3-like protein 3 CREB3L3 Tbio Transcription Factor -1.51965 41.5 33
Lipoprotein lipase LPL Tchem Enzyme -3.09646 876.3 338
Membrane-bound transcription factor site-2 protease MBTPS2 Tbio Enzyme -1.94015 86.1 119
Membrane-bound transcription factor site-1 protease MBTPS1 Tchem Enzyme -1.49326 34.9 64