Development Level

Tbio 229 | 11,445
Tdark 33 | 6,588
Tchem 24 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 40 | 979
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 11 | 278
abnormal embryo size 6 | 220
decreased circulating choleste... 6 | 93
preweaning lethality, incomple... 6 | 499
abnormal seminal vesicle morph... 5 | 114
embryonic growth retardation 5 | 106
abnormal neural tube closure 4 | 46
decreased body weight 4 | 161
decreased circulating HDL chol... 4 | 68
decreased circulating LDL chol... 4 | 38
decreased total body fat amoun... 4 | 207
abnormal heart morphology 3 | 162
cataract 3 | 92
decreased caudal vertebrae num... 3 | 53
decreased circulating alanine ... 3 | 47
decreased circulating alkaline... 3 | 46
decreased fasted circulating g... 3 | 65
decreased lactate dehydrogenas... 3 | 16
enlarged heart 3 | 210
enlarged lymph nodes 3 | 37
impaired glucose tolerance 3 | 75
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
abnormal allantois morphology 2 | 8
abnormal embryo turning 2 | 31
abnormal forebrain development 2 | 20
abnormal hindbrain development 2 | 16
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal limb bud morphology 2 | 17
abnormal midbrain development 2 | 20
abnormal neural tube morpholog... 2 | 12
abnormal optic vesicle formati... 2 | 4
abnormal otic vesicle morpholo... 2 | 3
abnormal pericardium morpholog... 2 | 26
abnormal pharyngeal arch morph... 2 | 8
abnormal somite shape 2 | 5
abnormal tail bud morphology 2 | 8
abnormal visceral yolk sac mor... 2 | 6
abnormal vitelline vasculature... 2 | 6
bleb 2 | 2
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating aspartat... 2 | 34
decreased circulating free fat... 2 | 31
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
edema 2 | 59
hydrometra 2 | 53
increased blood urea nitrogen ... 2 | 48
increased circulating free fat... 2 | 20
increased red blood cell distr... 2 | 34
increased total body fat amoun... 2 | 134
pale yolk sac 2 | 25
small testis 2 | 58
vertebral fusion 2 | 23
abnormal blood vessel morpholo... 1 | 5
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal pancreas morphology 1 | 13
abnormal retina morphology 1 | 71
abnormal skin coloration 1 | 25
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
abnormal vibrissa morphology 1 | 25
absent adrenal gland 1 | 2
absent lymph nodes 1 | 3
cardiovascular system phenotyp... 1 | 36
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased hematocrit 1 | 46
decreased red blood cell distr... 1 | 41
enlarged thymus 1 | 5
increased anti-nuclear antigen... 1 | 19
increased bone mineral density 1 | 72
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
microphthalmia 1 | 26
thrombocytosis 1 | 27

Disease

ovarian cancer 184 | 8,520
Carcinoma 172 | 11,493
osteosarcoma 144 | 7,950
glioblastoma 115 | 5,792
psoriasis 96 | 6,694
medulloblastoma, large-cell 90 | 6,241
atypical teratoid / rhabdoid tumor 85 | 5,112
lung cancer 75 | 4,740
ependymoma 73 | 4,679
Breast cancer 61 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 57 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 57 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 57 | 1,962
lung adenocarcinoma 56 | 2,716
Multiple myeloma 55 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,989
Kidney cancer 52 | 2,613
adult high grade glioma 51 | 3,801
Astrocytoma, Pilocytic 50 | 3,081
Autosomal recessive predisposition 50 | 1,442
malignant mesothelioma 49 | 3,232
group 3 medulloblastoma 47 | 4,104
pancreatic cancer 46 | 2,398
invasive ductal carcinoma 45 | 2,951
non-small cell lung cancer 44 | 2,890
tuberculosis 43 | 2,010
diabetes mellitus 39 | 1,728
Congenital disorder of glycosylation 38 | 54
lung carcinoma 38 | 2,843
primitive neuroectodermal tumor 38 | 3,035
oligodendroglioma 37 | 2,850
astrocytic glioma 34 | 2,597
group 4 medulloblastoma 33 | 1,855
subependymal giant cell astrocytoma 32 | 2,287
Epilepsy 30 | 792
Pick disease 30 | 1,894
astrocytoma 30 | 1,146
Cancer 28 | 2,499
Intellectual disability 28 | 1,016
Muscle hypotonia 28 | 571
Rheumatoid arthritis 28 | 1,191
non primary Sjogren syndrome sicca 28 | 891
ulcerative colitis 28 | 1,819
acute quadriplegic myopathy 26 | 1,158
cystic fibrosis 26 | 1,696
pituitary cancer 26 | 1,972
Seizures 25 | 596
Cognitive delay 24 | 608
Global developmental delay 24 | 608
Mental and motor retardation 24 | 608
interstitial cystitis 24 | 2,312
breast carcinoma 23 | 1,638
juvenile dermatomyositis 23 | 1,187
spina bifida 23 | 1,074
dermatomyositis 21 | 966
hepatocellular carcinoma 21 | 547
pancreatic carcinoma 21 | 562
pediatric high grade glioma 21 | 1,064
acute myeloid leukemia 19 | 783
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
Schizophrenia 18 | 1,160
active Crohn's disease 18 | 922
Waldenstrons macroglobulinemia 16 | 765
cutaneous lupus erythematosus 16 | 1,057
esophageal adenocarcinoma 16 | 737
primary pancreatic ductal adenocarcinoma 16 | 1,109
Duchenne muscular dystrophy 15 | 601
Failure to gain weight 15 | 365
Pediatric failure to thrive 15 | 365
Cerebellar Ataxia 14 | 304
adrenocortical carcinoma 14 | 1,428
colon cancer 14 | 1,478
Bipolar Disorder 13 | 666
Hepatomegaly 13 | 285
ductal carcinoma in situ 13 | 1,745
medulloblastoma 13 | 720
Melanoma 12 | 711
Small head 12 | 374
active ulcerative colitis 12 | 764
tuberculosis and treatment for 6 months 12 | 409
Acquired scoliosis 11 | 281
Curvature of spine 11 | 282
Prostatic Neoplasms 11 | 495
Splenomegaly 11 | 190
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
gastric cancer 11 | 459
posterior fossa group A ependymoma 11 | 468
Alzheimer's disease 10 | 658
Anemia 10 | 365
Cerebral atrophy 10 | 178
Liver cancer 10 | 604
Short stature 10 | 531
aldosterone-producing adenoma 10 | 665
nasopharyngeal carcinoma 10 | 1,058
Optic Atrophy 9 | 242
primary Sjogren syndrome 9 | 735

Tissue

Endocrine System 284 | 18,159
Female tissues 284 | 17,400
Skin and soft tissues 284 | 17,230
Digestive Tract 283 | 17,369
Liver and Pancreas 282 | 16,750
Nervous System 282 | 16,725
Blood and immune system 280 | 16,909
Male tissues 280 | 17,142
Urinary Tract 280 | 16,678
Cardiovascular System 277 | 15,192
Respiratory system 276 | 16,393

Target Family

Non-IDG 140 | 12,091
Enzyme 139 | 4,145
Kinase 3 | 634
Transporter 3 | 473
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

Reactome Pathway

Asparagine N-linked glycosylat... 287 | 287
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 Tchem Enzyme -1.80418 63.8 91
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase ALG10 Tbio Enzyme -1.32430 19.1 70
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303
Alpha-soluble NSF attachment protein NAPA Tbio Non-IDG -1.91664 86.4 148
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.27566 1855.5 168
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178