Development Level

Tchem 27 | 1,598
Tbio 24 | 11,445
Tclin 4 | 613
Tdark 3 | 6,588

IMPC Phenotype

abnormal heart morphology 2 | 162
hydrometra 2 | 53
increased monocyte cell number 2 | 63
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal epididymis morphology 1 | 42
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
hyperactivity 1 | 148
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 34 | 11,493
osteosarcoma 30 | 7,950
psoriasis 28 | 6,694
ovarian cancer 25 | 8,520
lung cancer 24 | 4,740
Cancer 21 | 2,499
interstitial cystitis 21 | 2,312
lung carcinoma 20 | 2,843
non-small cell lung cancer 20 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
pancreatic cancer 18 | 2,398
medulloblastoma, large-cell 17 | 6,241
lung adenocarcinoma 16 | 2,716
glioblastoma 15 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
invasive ductal carcinoma 14 | 2,951
adrenocortical carcinoma 13 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Hypertension 12 | 396
cystic fibrosis 12 | 1,696
ependymoma 12 | 4,679
malignant mesothelioma 12 | 3,232
ulcerative colitis 12 | 1,819
Prostatic Neoplasms 11 | 495
Schizophrenia 11 | 1,160
group 3 medulloblastoma 11 | 4,104
Astrocytoma, Pilocytic 10 | 3,081
atypical teratoid / rhabdoid tumor 10 | 5,112
tuberculosis 10 | 2,010
Asthma 9 | 385
Atherosclerosis 9 | 291
Breast cancer 9 | 3,578
Rheumatoid arthritis 9 | 1,191
adult high grade glioma 9 | 3,801
colon cancer 9 | 1,478
diabetes mellitus 9 | 1,728
oligodendroglioma 9 | 2,850
primary pancreatic ductal adenocarcinoma 9 | 1,109
Autosomal recessive predisposition 8 | 1,442
Breast Neoplasms 8 | 445
Cerebrovascular disease 8 | 238
Coronary artery disease 8 | 268
Mammary Neoplasms 8 | 425
ductal carcinoma in situ 8 | 1,745
Atopic dermatitis 7 | 952
Bipolar Disorder 7 | 666
Depressive disorder 7 | 409
Liver Cirrhosis, Experimental 7 | 769
Obesity 7 | 678
Osteoarthritis 7 | 184
Pain 7 | 103
astrocytoma 7 | 1,146
breast carcinoma 7 | 1,638
esophageal adenocarcinoma 7 | 737
head and neck cancer and chronic obstructive pulmonary disease 7 | 239
primitive neuroectodermal tumor 7 | 3,035
Amyotrophic lateral sclerosis 6 | 451
Chemical and Drug Induced Liver Injury 6 | 195
Liver disease 6 | 237
Melanoma 6 | 711
cutaneous lupus erythematosus 6 | 1,057
head and neck cancer 6 | 271
pituitary cancer 6 | 1,972
subependymal giant cell astrocytoma 6 | 2,287
Arthritis 5 | 290
Cardiovascular Diseases 5 | 59
Drug-Related Side Effects and Adverse Reactions 5 | 62
Endometriosis 5 | 540
Heart failure 5 | 162
Lung Neoplasms 5 | 232
Patent ductus arteriosus 5 | 90
active Crohn's disease 5 | 922
medulloblastoma 5 | 720
nasopharyngeal carcinoma 5 | 1,058
pancreatic carcinoma 5 | 562
primary Sjogren syndrome 5 | 735
Adenoma 4 | 167
Arthritis, Rheumatoid 4 | 174
Autistic Disorder 4 | 364
Cholestasis 4 | 155
Colorectal Neoplasms 4 | 243
Epilepsy 4 | 792
Fever 4 | 138
Hyperalgesia 4 | 83
Kidney disease 4 | 430
Liver diseases 4 | 87
Major Depressive Disorder 4 | 301
Mental Depression 4 | 333
Pick disease 4 | 1,894
Reperfusion Injury 4 | 86
Toxic encephalopathy 4 | 141
Unipolar Depression 4 | 250
Urticaria 4 | 67
adrenocortical adenoma 4 | 131
aldosterone-producing adenoma 4 | 665
pediatric high grade glioma 4 | 1,064
periodontitis 4 | 293
posterior fossa group B ependymoma 4 | 416
tuberculosis and treatment for 3 months 4 | 179

Tissue

Digestive Tract 57 | 17,369
Female tissues 57 | 17,400
Skin and soft tissues 57 | 17,230
Male tissues 56 | 17,142
Liver and Pancreas 55 | 16,750
Endocrine System 54 | 18,159
Urinary Tract 54 | 16,678
Nervous System 52 | 16,725
Blood and immune system 51 | 16,909
Respiratory system 51 | 16,393
Cardiovascular System 41 | 15,192

Target Family

Enzyme 44 | 4,145
Non-IDG 13 | 12,091
Kinase 1 | 634

Reactome Pathway

Arachidonic acid metabolism 58 | 58
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Prostaglandin reductase 1 PTGR1 Tbio Enzyme -1.28265 22.7 156
Phylloquinone omega-hydroxylase CYP4F11 CYP4F11 Tbio Enzyme -0.71213 6.60 96
15-hydroxyprostaglandin dehydrogenase [NAD(+)] HPGD Tchem Enzyme -2.26841 191.0 354
Cytochrome P450 4A11 CYP4A11 Tbio Non-IDG -1.97180 93.7 142
Prostaglandin G/H synthase 1 PTGS1 Tclin Enzyme -3.23035 1641.3 479
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.06834 12504.5 731
Cytochrome P450 4F8 CYP4F8 Tdark Non-IDG 0.00000 34
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 Tbio Enzyme -2.88891 707.6 227
Cytochrome P450 2C8 CYP2C8 Tchem Non-IDG -2.55207 348.9 159
Leukotriene C4 synthase LTC4S Tchem Enzyme -1.98032 93.9 89