Development Level

Tbio 25 | 10,625
Tchem 25 | 1,890
Tclin 4 | 602
Tdark 4 | 7,003

IMPC Phenotype

abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal joint morphology 1 | 14
abnormal optic disc morphology 1 | 10
abnormal testis morphology 1 | 30
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased cervical vertebrae n... 1 | 12
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating triglyce... 1 | 83
decreased mean platelet volume 1 | 12
enlarged epididymis 1 | 27
hyperactivity 1 | 108
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased mean corpuscular hem... 1 | 93
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
small testis 1 | 37

Disease

osteosarcoma 31 | 7,933
psoriasis 29 | 6,685
ovarian cancer 26 | 8,491
lung cancer 23 | 4,473
Cancer 21 | 2,346
interstitial cystitis 21 | 2,299
lung carcinoma 21 | 2,844
non-small cell lung cancer 21 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
medulloblastoma, large-cell 18 | 6,234
pancreatic cancer 18 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
lung adenocarcinoma 16 | 2,714
glioblastoma 15 | 5,572
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
invasive ductal carcinoma 14 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
ulcerative colitis 14 | 2,087
adrenocortical carcinoma 13 | 1,427
malignant mesothelioma 13 | 3,163
cystic fibrosis 11 | 1,670
pilocytic astrocytoma 11 | 3,086
Hypertension 10 | 293
Prostatic Neoplasms 10 | 471
Asthma 9 | 349
Atherosclerosis 9 | 275
Mammary Neoplasms 9 | 410
Rheumatoid Arthritis 9 | 1,170
colon cancer 9 | 1,475
group 4 medulloblastoma 9 | 1,875
oligodendroglioma 9 | 2,849
pediatric high grade glioma 9 | 2,712
primary pancreatic ductal adenocarcinoma 9 | 1,271
tuberculosis 9 | 1,563
Cerebrovascular disease 8 | 231
Coronary artery disease 8 | 240
Peripheral Neuropathy 8 | 303
atypical teratoid / rhabdoid tumor 8 | 4,369
diabetes mellitus 8 | 1,663
ductal carcinoma in situ 8 | 1,745
Atopic dermatitis 7 | 944
Breast cancer 7 | 3,098
Osteoarthritis 7 | 96
astrocytoma 7 | 1,493
breast carcinoma 7 | 1,614
esophageal adenocarcinoma 7 | 737
posterior fossa group B ependymoma 7 | 1,530
primitive neuroectodermal tumor 7 | 3,031
subependymal giant cell astrocytoma 7 | 2,287
Amyotrophic Lateral Sclerosis 6 | 432
Liver disease 6 | 219
Lung Neoplasms 6 | 171
Obesity 6 | 616
active Crohn's disease 6 | 918
cutaneous lupus erythematosus 6 | 1,056
group 3 medulloblastoma 6 | 2,254
head and neck cancer 6 | 270
head and neck cancer and chronic obstructive pulmonary disease 6 | 237
pituitary cancer 6 | 1,972
posterior fossa group A ependymoma 6 | 1,511
Adverse reaction to drug 5 | 54
Cardiovascular Diseases 5 | 50
Colorectal Neoplasms 5 | 217
Drug-Induced Liver Injury 5 | 118
Endometriosis 5 | 535
Hypertensive disease 5 | 193
Patent ductus arteriosus 5 | 23
atypical teratoid/rhabdoid tumor 5 | 1,095
medulloblastoma 5 | 1,524
nasopharyngeal carcinoma 5 | 1,056
pancreatic carcinoma 5 | 567
primary Sjogren syndrome 5 | 788
Actinic keratosis 4 | 22
Adenoma 4 | 165
Arthritis 4 | 248
Autistic Disorder 4 | 320
Drug allergy 4 | 36
Dysmenorrhea 4 | 19
Heart failure 4 | 80
Hyperalgesia 4 | 71
Juvenile rheumatoid arthritis 4 | 105
Kidney disease 4 | 397
Liver diseases 4 | 66
Menorrhagia 4 | 8
Pain 4 | 70
Pick disease 4 | 1,893
Reperfusion Injury 4 | 84
Schizophrenia 4 | 503
Squamous cell carcinoma 4 | 96
adrenocortical adenoma 4 | 134
adult high grade glioma 4 | 2,148
aldosterone-producing adenoma 4 | 664
ependymoma 4 | 2,514
tuberculosis and treatment for 3 months 4 | 327
Down syndrome 3 | 548
Male infertility 3 | 170
Vascular disease 3 | 281
chronic rhinosinusitis 3 | 512
inflammatory breast cancer 3 | 404
mucosa-associated lymphoid tissue lymphoma 3 | 480

Tissue

Blood and immune system 58 | 17,994
Cardiovascular System 58 | 17,957
Digestive Tract 58 | 18,472
Endocrine System 58 | 18,511
Female tissues 58 | 18,646
Liver and Pancreas 58 | 18,135
Male tissues 58 | 17,968
Nervous System 58 | 18,560
Skin and soft tissues 58 | 18,114
Urinary Tract 58 | 18,443
Respiratory system 57 | 17,483

Target Family

Enzyme 43 | 4,146
Non-IDG 13 | 11,969
Kinase 1 | 634
Transporter 1 | 473

Reactome Pathway

Arachidonic acid metabolism 58 | 58
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CYP8B1 Tbio Enzyme -1.62014 38.3 100
Cytochrome P450 1A1 CYP1A1 Tchem Non-IDG -3.53853 3553.5 340
15-hydroxyprostaglandin dehydrogenase [NAD(+)] HPGD Tchem Enzyme -2.23872 176.6 308
Cytochrome P450 4A22 CYP4A22 Tbio Non-IDG -0.91578 6.79 68
Hematopoietic prostaglandin D synthase HPGDS Tchem Enzyme -3.72716 4165.3 68
Acyl-CoA wax alcohol acyltransferase 1 AWAT1 Tbio Enzyme -1.68066 33.2 60
Cytochrome P450 1A2 CYP1A2 Tchem Non-IDG -3.31421 2022.5 420
Fatty-acid amide hydrolase 2 FAAH2 Tchem Enzyme -0.75950 4.73 94
Arachidonate 12-lipoxygenase, 12R-type ALOX12B Tbio Enzyme -1.34255 22.4 63
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 Tbio Enzyme -2.80351 588.3 200