Development Level

Tbio 25 | 10,625
Tchem 25 | 1,890
Tclin 4 | 602
Tdark 4 | 7,003

IMPC Term

abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal joint morphology 1 | 14
abnormal optic disc morphology 1 | 10
abnormal testis morphology 1 | 30
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased cervical vertebrae n... 1 | 12
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating triglyce... 1 | 83
decreased mean platelet volume 1 | 12
enlarged epididymis 1 | 27
hyperactivity 1 | 108
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased mean corpuscular hem... 1 | 93
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
small testis 1 | 37

Disease

osteosarcoma 31 | 7,933
psoriasis 29 | 6,685
ovarian cancer 26 | 8,484
lung cancer 23 | 4,466
Cancer 21 | 2,346
interstitial cystitis 21 | 2,299
lung carcinoma 21 | 2,844
non-small cell lung cancer 21 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
medulloblastoma, large-cell 18 | 6,234
pancreatic cancer 18 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
lung adenocarcinoma 16 | 2,713
glioblastoma 15 | 5,572
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
invasive ductal carcinoma 14 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
ulcerative colitis 14 | 2,087
adrenocortical carcinoma 13 | 1,427
malignant mesothelioma 13 | 3,162
cystic fibrosis 11 | 1,665
pilocytic astrocytoma 11 | 3,086
Prostatic Neoplasms 10 | 471
Asthma 9 | 349
Atherosclerosis 9 | 275
Hypertension 9 | 287
Mammary Neoplasms 9 | 410
Rheumatoid Arthritis 9 | 1,160
colon cancer 9 | 1,475
group 4 medulloblastoma 9 | 1,875
oligodendroglioma 9 | 2,849
pediatric high grade glioma 9 | 2,712
primary pancreatic ductal adenocarcinoma 9 | 1,271
tuberculosis 9 | 1,557
Cerebrovascular disease 8 | 231
Coronary artery disease 8 | 240
Peripheral Neuropathy 8 | 303
atypical teratoid / rhabdoid tumor 8 | 4,369
diabetes mellitus 8 | 1,663
ductal carcinoma in situ 8 | 1,745
Atopic dermatitis 7 | 944
Breast cancer 7 | 3,094
Osteoarthritis 7 | 96
astrocytoma 7 | 1,493
breast carcinoma 7 | 1,614
esophageal adenocarcinoma 7 | 737
posterior fossa group B ependymoma 7 | 1,530
primitive neuroectodermal tumor 7 | 3,031
subependymal giant cell astrocytoma 7 | 2,287
Amyotrophic Lateral Sclerosis 6 | 431
Liver disease 6 | 219
Lung Neoplasms 6 | 171
Obesity 6 | 616
active Crohn's disease 6 | 918
cutaneous lupus erythematosus 6 | 1,056
group 3 medulloblastoma 6 | 2,254
head and neck cancer 6 | 270
head and neck cancer and chronic obstructive pulmonary disease 6 | 237
pituitary cancer 6 | 1,972
posterior fossa group A ependymoma 6 | 1,511
Adverse reaction to drug 5 | 54
Cardiovascular Diseases 5 | 50
Colorectal Neoplasms 5 | 217
Drug-Induced Liver Injury 5 | 118
Endometriosis 5 | 535
Hypertensive disease 5 | 193
Patent ductus arteriosus 5 | 23
atypical teratoid/rhabdoid tumor 5 | 1,095
medulloblastoma 5 | 1,524
nasopharyngeal carcinoma 5 | 1,056
pancreatic carcinoma 5 | 567
primary Sjogren syndrome 5 | 789
Actinic keratosis 4 | 22
Adenoma 4 | 165
Arthritis 4 | 248
Autistic Disorder 4 | 320
Drug allergy 4 | 36
Dysmenorrhea 4 | 19
Heart failure 4 | 80
Hyperalgesia 4 | 71
Juvenile rheumatoid arthritis 4 | 104
Kidney disease 4 | 396
Liver diseases 4 | 66
Menorrhagia 4 | 8
Pain 4 | 70
Pick disease 4 | 1,893
Reperfusion Injury 4 | 84
Schizophrenia 4 | 501
Squamous cell carcinoma 4 | 94
adrenocortical adenoma 4 | 134
adult high grade glioma 4 | 2,148
aldosterone-producing adenoma 4 | 664
ependymoma 4 | 2,514
tuberculosis and treatment for 3 months 4 | 327
Down syndrome 3 | 548
Male infertility 3 | 170
Vascular disease 3 | 281
chronic rhinosinusitis 3 | 512
inflammatory breast cancer 3 | 404
mucosa-associated lymphoid tissue lymphoma 3 | 480

Tissue

Blood and immune system 58 | 17,995
Cardiovascular System 58 | 17,958
Digestive Tract 58 | 18,473
Endocrine System 58 | 18,512
Female tissues 58 | 18,647
Liver and Pancreas 58 | 18,136
Male tissues 58 | 17,969
Nervous System 58 | 18,561
Skin and soft tissues 58 | 18,115
Urinary Tract 58 | 18,444
Respiratory system 57 | 17,484

Target Family

Enzyme 43 | 4,146
Non-IDG 13 | 11,971
Kinase 1 | 634
Transporter 1 | 473

Reactome Pathway

Arachidonic acid metabolism 58 | 58
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Prostaglandin G/H synthase 1 PTGS1 Tclin Enzyme -3.20847 1594.9 391
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.03668 12041.6 648
Arachidonate 15-lipoxygenase B ALOX15B Tchem Enzyme -1.69492 53.8 147
Cytochrome P450 4F22 CYP4F22 Tbio Non-IDG -1.98060 100.6 25
Thromboxane-A synthase TBXAS1 Tchem Enzyme -3.06668 1228.9 241
Cytochrome P450 4B1 CYP4B1 Tbio Non-IDG -1.77340 65.4 88
Gamma-glutamyltransferase 5 GGT5 Tbio Enzyme -1.87019 73.9 68
Prostaglandin reductase 1 PTGR1 Tbio Enzyme -1.20481 21.1 134
Cytochrome P450 2J2 CYP2J2 Tchem Non-IDG -2.03738 133.3 162
Cytochrome P450 4F8 CYP4F8 Tdark Non-IDG 0.00000 28