Development Level

Tbio 46 | 11,651
Tdark 4 | 6,593
Tchem 3 | 1,388
Tclin 1 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

abnormal bone structure 4 | 187
increased heart weight 4 | 62
increased startle reflex 4 | 112
increased circulating total pr... 3 | 28
preweaning lethality, incomple... 3 | 499
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal kidney morphology 1 | 65
decreased circulating chloride... 1 | 30
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating serum al... 1 | 22
increased lymphocyte cell numb... 1 | 32
increased total retina thickne... 1 | 4
persistence of hyaloid vascula... 1 | 33
small kidney 1 | 16
small superior vagus ganglion 1 | 74

Disease

Carcinoma 30 | 11,493
ovarian cancer 25 | 8,520
osteosarcoma 22 | 7,950
medulloblastoma, large-cell 21 | 6,241
glioblastoma 20 | 5,792
psoriasis 20 | 6,694
ependymoma 18 | 4,679
atypical teratoid / rhabdoid tumor 16 | 5,112
pancreatic cancer 16 | 2,398
non-small cell lung cancer 15 | 2,890
lung cancer 14 | 4,740
primitive neuroectodermal tumor 14 | 3,035
Astrocytoma, Pilocytic 13 | 3,081
adult high grade glioma 13 | 3,801
group 3 medulloblastoma 13 | 4,104
lung carcinoma 13 | 2,843
Breast cancer 12 | 3,578
invasive ductal carcinoma 12 | 2,951
astrocytic glioma 11 | 2,597
interstitial cystitis 11 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
pituitary cancer 11 | 1,972
Carney complex 10 | 25
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
lung adenocarcinoma 10 | 2,716
oligodendroglioma 10 | 2,850
Cancer 9 | 2,499
Depressive disorder 9 | 409
Kidney cancer 9 | 2,613
Kidney disease 9 | 430
Obesity 9 | 678
Pick disease 9 | 1,894
subependymal giant cell astrocytoma 9 | 2,287
Primary pigmented nodular adrenocortical disease 8 | 13
diabetes mellitus 8 | 1,728
group 4 medulloblastoma 8 | 1,855
malignant mesothelioma 8 | 3,232
ulcerative colitis 8 | 1,819
Cushing's syndrome 7 | 48
Hypertensive disease 7 | 292
active Crohn's disease 7 | 922
breast carcinoma 7 | 1,638
ductal carcinoma in situ 7 | 1,745
Duchenne muscular dystrophy 6 | 601
Hypertension 6 | 396
Intellectual disability 6 | 1,016
Liver cancer 6 | 604
Meniere's disease 6 | 24
Nephrogenic Diabetes Insipidus 6 | 16
Pituitary adenoma 6 | 38
Schizophrenia 6 | 1,160
Substance Withdrawal Syndrome 6 | 55
primary pancreatic ductal adenocarcinoma 6 | 1,109
Acrodysostosis 5 | 12
Acromegaly 5 | 51
Adenoma 5 | 167
Autosomal recessive predisposition 5 | 1,442
Bipolar Disorder 5 | 666
Brachydactyly 5 | 156
Brain Edema 5 | 50
Cardiomyopathies 5 | 110
Epilepsy 5 | 792
Hyperthyroidism 5 | 53
Hypothyroidism 5 | 122
McCune Albright syndrome 5 | 19
Mental Depression 5 | 333
Mood Disorders 5 | 184
Multiple Endocrine Neoplasia Type 1 5 | 29
Pseudohypoparathyroidism 5 | 18
Short stature 5 | 531
acute quadriplegic myopathy 5 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
gastric carcinoma 5 | 807
pancreatic carcinoma 5 | 562
Acquired metabolic disease 4 | 336
Adrenal gland cancer 4 | 12
Congestive heart failure 4 | 113
Diarrhea 4 | 253
Fibrous dysplasia 4 | 15
Generalized osteopenia 4 | 99
Heart failure 4 | 162
Hyperphosphatemia 4 | 32
Hypoparathyroidism 4 | 41
Major Depressive Disorder 4 | 301
Osteopenia 4 | 99
Osteoporosis 4 | 363
Plummer's disease 4 | 11
Polycystic ovary syndrome 4 | 360
Polyhydramnios 4 | 108
Seizures 4 | 596
Thyroid cancer 4 | 36
Unipolar Depression 4 | 250
aldosterone-producing adenoma 4 | 665
cystic fibrosis 4 | 1,696
juvenile dermatomyositis 4 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
sarcoidosis 4 | 370
substance-related disorder 4 | 162
tuberculosis 4 | 2,010

Tissue

Endocrine System 50 | 18,159
Digestive Tract 49 | 17,369
Male tissues 48 | 17,142
Blood and immune system 47 | 16,909
Liver and Pancreas 47 | 16,750
Skin and soft tissues 46 | 17,230
Urinary Tract 46 | 16,678
Female tissues 45 | 17,400
Nervous System 45 | 16,725
Cardiovascular System 43 | 15,192
Respiratory system 43 | 16,393

Target Family

Non-IDG 37 | 12,091
Enzyme 13 | 4,145
Kinase 3 | 634
GPCR 1 | 408

Reactome Pathway

Aquaporin-mediated transport 54 | 54
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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