Development Level

Tbio 23 | 11,651
Tchem 12 | 1,388
Tclin 2 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal retina morphology 2 | 71
increased bone mineral density 2 | 72
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal head morphology 1 | 10
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vitreous body morphol... 1 | 10
decreased body weight 1 | 161
decreased cardiac muscle contr... 1 | 11
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hyperactivity 1 | 148
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased granulocyte number 1 | 1
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
polycystic kidney 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58

Disease

Carcinoma 32 | 11,493
ovarian cancer 26 | 8,520
osteosarcoma 22 | 7,950
Cancer 20 | 2,499
psoriasis 20 | 6,694
ependymoma 19 | 4,679
lung cancer 19 | 4,740
Breast cancer 17 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
glioblastoma 15 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
medulloblastoma, large-cell 15 | 6,241
Kidney cancer 14 | 2,613
non-small cell lung cancer 14 | 2,890
atypical teratoid / rhabdoid tumor 13 | 5,112
interstitial cystitis 13 | 2,312
pancreatic cancer 13 | 2,398
Astrocytoma, Pilocytic 11 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
lung carcinoma 11 | 2,843
oligodendroglioma 11 | 2,850
subependymal giant cell astrocytoma 11 | 2,287
adult high grade glioma 10 | 3,801
group 3 medulloblastoma 10 | 4,104
lung adenocarcinoma 10 | 2,716
malignant mesothelioma 10 | 3,232
invasive ductal carcinoma 9 | 2,951
primitive neuroectodermal tumor 9 | 3,035
Mammary Neoplasms 8 | 425
diabetes mellitus 8 | 1,728
Autosomal recessive predisposition 7 | 1,442
Breast Neoplasms 7 | 445
Failure to gain weight 7 | 365
Pediatric failure to thrive 7 | 365
astrocytic glioma 7 | 2,597
breast carcinoma 7 | 1,638
ductal carcinoma in situ 7 | 1,745
esophageal adenocarcinoma 7 | 737
spina bifida 7 | 1,074
Alzheimer's disease 6 | 658
Carcinoma, Hepatocellular 6 | 228
Liver carcinoma 6 | 240
Melanoma 6 | 711
Multiple myeloma 6 | 1,332
Rheumatoid arthritis 6 | 1,191
cystic fibrosis 6 | 1,696
pituitary cancer 6 | 1,972
primary pancreatic ductal adenocarcinoma 6 | 1,109
Cell Transformation, Neoplastic 5 | 97
Cerebrovascular disease 5 | 238
Down syndrome 5 | 499
Hypertension 5 | 396
Inflammatory bowel disease 5 | 151
Kidney disease 5 | 430
Liver Cirrhosis, Experimental 5 | 769
Liver cancer 5 | 604
Neoplastic Cell Transformation 5 | 89
Parkinson's disease 5 | 392
Pick disease 5 | 1,894
Skin cancer 5 | 469
Splenomegaly 5 | 190
Stomach Neoplasms 5 | 300
Waldenstrons macroglobulinemia 5 | 765
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
ulcerative colitis 5 | 1,819
Alopecia 4 | 115
Amyotrophic lateral sclerosis 4 | 451
Bullous pemphigoid 4 | 18
Colorectal Neoplasms 4 | 243
Disease Models, Animal 4 | 155
Immune system cancer 4 | 140
Intellectual disability 4 | 1,016
Lung Neoplasms 4 | 232
Lymphoid leukemia 4 | 160
Nail Diseases 4 | 24
Nail abnormality 4 | 22
Neoplasm Invasiveness 4 | 161
Neurodegenerative disease 4 | 414
Obesity 4 | 678
Osteoporosis 4 | 363
Palmoplantar keratosis 4 | 74
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Stomach cancer 4 | 30
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
gastric carcinoma 4 | 807
group 4 medulloblastoma 4 | 1,855
juvenile dermatomyositis 4 | 1,187
mucosa-associated lymphoid tissue lymphoma 4 | 484
tuberculosis 4 | 2,010
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Reperfusion Injury 3 | 86
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
colon cancer 3 | 1,478
fibroadenoma 3 | 559
hepatocellular carcinoma 3 | 547
urothelial carcinoma 3 | 318

Tissue

Blood and immune system 36 | 16,909
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Respiratory system 35 | 16,393
Cardiovascular System 34 | 15,192

Target Family

Non-IDG 23 | 12,091
Kinase 7 | 634
Enzyme 6 | 4,145
Transcription Factor 1 | 1,400

Reactome Pathway

Apoptotic cleavage of cellular... 37 | 37
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
Desmoglein-1 DSG1 Tbio Non-IDG -2.72159 516.2 406
Drebrin-like protein DBNL Tbio Non-IDG -1.16567 21.1 172
DNA-binding protein SATB1 SATB1 Tbio Transcription Factor -2.28849 219.7 322
Caspase-3 CASP3 Tchem Enzyme -4.32112 18132.3 1689
Baculoviral IAP repeat-containing protein 2 BIRC2 Tchem Non-IDG -2.53423 308.7 351
Adenomatous polyposis coli protein APC Tbio Non-IDG -1.90646 66.5 508
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Prelamin-A/C LMNA Tbio Non-IDG -3.03952 1089.9 1005
Catenin beta-1 CTNNB1 Tchem Non-IDG -3.99948 9786.0 3058