Development Level

Tbio 118 | 11,445
Tchem 39 | 1,598
Tclin 8 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 15 | 979
abnormal retina morphology 3 | 71
decreased vertical activity 3 | 208
hyperactivity 3 | 148
increased mean corpuscular hem... 3 | 96
preweaning lethality, incomple... 3 | 499
abnormal bone mineralization 2 | 38
abnormal vitreous body morphol... 2 | 10
decreased body weight 2 | 161
decreased circulating choleste... 2 | 93
decreased mean corpuscular vol... 2 | 79
edema 2 | 59
embryonic lethality prior to t... 2 | 278
increased bone mineral density 2 | 72
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 36
increased total body fat amoun... 2 | 134
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small superior vagus ganglion 2 | 74
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
absent testes 1 | 6
decreased bone mineral content 1 | 151
decreased cardiac muscle contr... 1 | 11
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased lymphocyte cell numb... 1 | 83
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased eosinophil cell numb... 1 | 11
increased granulocyte number 1 | 1
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
male infertility 1 | 123
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small testis 1 | 58
thrombocytosis 1 | 27

Disease

ovarian cancer 111 | 8,520
Carcinoma 97 | 11,493
psoriasis 86 | 6,694
osteosarcoma 83 | 7,950
lung cancer 81 | 4,740
Cancer 74 | 2,499
glioblastoma 67 | 5,792
medulloblastoma, large-cell 59 | 6,241
atypical teratoid / rhabdoid tumor 54 | 5,112
Breast cancer 53 | 3,578
ependymoma 51 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,291
Multiple myeloma 42 | 1,332
malignant mesothelioma 42 | 3,232
adult high grade glioma 40 | 3,801
Astrocytoma, Pilocytic 35 | 3,081
lung adenocarcinoma 35 | 2,716
non-small cell lung cancer 35 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
oligodendroglioma 32 | 2,850
pancreatic cancer 32 | 2,398
diabetes mellitus 31 | 1,728
group 3 medulloblastoma 30 | 4,104
Kidney cancer 28 | 2,613
dermatomyositis 28 | 966
invasive ductal carcinoma 28 | 2,951
subependymal giant cell astrocytoma 28 | 2,287
lung carcinoma 27 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,962
group 4 medulloblastoma 25 | 1,855
interstitial cystitis 25 | 2,312
primitive neuroectodermal tumor 25 | 3,035
Schizophrenia 23 | 1,160
astrocytic glioma 23 | 2,597
Waldenstrons macroglobulinemia 22 | 765
tuberculosis 21 | 2,010
ulcerative colitis 21 | 1,819
Alzheimer's disease 19 | 658
Breast Neoplasms 19 | 445
Pick disease 19 | 1,894
hepatocellular carcinoma 19 | 547
juvenile dermatomyositis 19 | 1,187
pituitary cancer 19 | 1,972
HIV Infections 18 | 102
Mammary Neoplasms 18 | 425
astrocytoma 18 | 1,146
breast carcinoma 17 | 1,638
primary pancreatic ductal adenocarcinoma 17 | 1,109
Liver Cirrhosis, Experimental 16 | 769
Prostatic Neoplasms 16 | 495
Rheumatoid arthritis 16 | 1,191
acute quadriplegic myopathy 16 | 1,158
Vascular disease 15 | 319
acute myeloid leukemia 15 | 783
adrenocortical carcinoma 15 | 1,428
cystic fibrosis 15 | 1,696
ductal carcinoma in situ 15 | 1,745
Bipolar Disorder 14 | 666
Carcinoma, Hepatocellular 14 | 228
Liver carcinoma 14 | 240
Autosomal recessive predisposition 13 | 1,442
Lung Neoplasms 13 | 232
Melanoma 13 | 711
Obesity 13 | 678
Parkinson's disease 13 | 392
colon cancer 13 | 1,478
cutaneous lupus erythematosus 13 | 1,057
esophageal adenocarcinoma 13 | 737
spina bifida 13 | 1,074
Colorectal Neoplasms 12 | 243
Hypersensitivity reaction type II disease 12 | 253
Kidney disease 12 | 430
Multiple Sclerosis 12 | 540
Neoplasm Metastasis 12 | 168
Splenomegaly 12 | 190
Stomach Neoplasms 12 | 300
gastric carcinoma 12 | 807
Duchenne muscular dystrophy 11 | 601
Intellectual disability 11 | 1,016
Lymphoid leukemia 11 | 160
medulloblastoma 11 | 720
non primary Sjogren syndrome sicca 11 | 891
primary Sjogren syndrome 11 | 735
Cell Transformation, Neoplastic 10 | 97
Inflammatory bowel disease 10 | 151
Liver disease 10 | 237
Neoplastic Cell Transformation 10 | 89
Osteoporosis 10 | 363
Skin cancer 10 | 469
Squamous cell carcinoma 10 | 129
aldosterone-producing adenoma 10 | 665
Arthritis 9 | 290
Diabetes Mellitus, Non-Insulin-Dependent 9 | 145
Epilepsy 9 | 792
Failure to gain weight 9 | 365
Immune system cancer 9 | 140
Pediatric failure to thrive 9 | 365
Polycystic ovary syndrome 9 | 360
Seizures 9 | 596

Tissue

Endocrine System 166 | 18,159
Blood and immune system 165 | 16,909
Digestive Tract 165 | 17,369
Female tissues 165 | 17,400
Male tissues 165 | 17,142
Nervous System 165 | 16,725
Urinary Tract 165 | 16,678
Respiratory system 164 | 16,393
Skin and soft tissues 164 | 17,230
Liver and Pancreas 163 | 16,750
Cardiovascular System 158 | 15,192

Target Family

Non-IDG 90 | 12,091
Enzyme 53 | 4,145
Kinase 16 | 634
Transcription Factor 10 | 1,400

Reactome Pathway

Apoptosis 169 | 169
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Melanoma-associated antigen D1 MAGED1 Tbio Non-IDG -1.55131 46.3 245
Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 Tbio Non-IDG -2.70122 462.2 347
TIR domain-containing adapter molecule 2 TICAM2 Tbio Non-IDG -1.18212 14.6 258
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Serine/threonine-protein kinase 24 STK24 Tchem Kinase -2.24110 132.9 243
Apoptosis-stimulating of p53 protein 2 TP53BP2 Tbio Non-IDG -1.85307 72.5 189
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Death-associated protein kinase 2 DAPK2 Tchem Kinase -1.39206 28.7 440