Development Level

Tbio 100 | 10,625
Tchem 57 | 1,890
Tclin 8 | 602
Tdark 2 | 7,003

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 11 | 633
abnormal retina morphology 3 | 100
abnormal bone mineralization 2 | 55
decreased body length 2 | 108
decreased body weight 2 | 174
embryonic lethality prior to t... 2 | 187
hydrops fetalis 2 | 22
increased bone mineral density 2 | 52
increased circulating alkaline... 2 | 119
persistence of hyaloid vascula... 2 | 22
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat- hair morphology 1 | 18
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal vitreous body morphol... 1 | 7
decreased Ly6C high monocyte n... 1 | 18
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased lean body mass 1 | 195
decreased neutrophil cell numb... 1 | 37
decreased total retina thickne... 1 | 20
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
increased Ly6C low monocyte nu... 1 | 8
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased circulating LDL chol... 1 | 15
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased granulocyte number 1 | 8
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
male infertility 1 | 62
oligodactyly 1 | 14
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytosis 1 | 23

Disease

ovarian cancer 110 | 8,491
psoriasis 85 | 6,685
osteosarcoma 82 | 7,933
lung cancer 78 | 4,473
Cancer 75 | 2,346
glioblastoma 65 | 5,572
medulloblastoma, large-cell 59 | 6,234
atypical teratoid / rhabdoid tumor 47 | 4,369
Breast cancer 46 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
Multiple myeloma 40 | 1,327
malignant mesothelioma 40 | 3,163
lung adenocarcinoma 35 | 2,714
non-small cell lung cancer 35 | 2,798
pilocytic astrocytoma 35 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,988
oligodendroglioma 32 | 2,849
diabetes mellitus 31 | 1,663
pancreatic cancer 31 | 2,300
invasive ductal carcinoma 29 | 2,950
pediatric high grade glioma 29 | 2,712
ependymoma 28 | 2,514
lung carcinoma 28 | 2,844
subependymal giant cell astrocytoma 28 | 2,287
dermatomyositis 27 | 966
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,956
interstitial cystitis 25 | 2,299
primitive neuroectodermal tumor 25 | 3,031
group 4 medulloblastoma 24 | 1,875
Carcinoma 23 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795
ulcerative colitis 22 | 2,087
Waldenstrons macroglobulinemia 21 | 764
astrocytic glioma 21 | 2,241
juvenile dermatomyositis 20 | 1,189
Pick disease 19 | 1,893
adult high grade glioma 19 | 2,148
hepatocellular carcinoma 19 | 550
pituitary cancer 19 | 1,972
primary pancreatic ductal adenocarcinoma 19 | 1,271
astrocytoma 18 | 1,493
tuberculosis 18 | 1,563
Alzheimer's disease 17 | 644
HIV Infections 17 | 99
medulloblastoma 17 | 1,524
posterior fossa group A ependymoma 17 | 1,511
acute quadriplegic myopathy 16 | 1,157
ductal carcinoma in situ 16 | 1,745
Mammary Neoplasms 15 | 410
Prostatic Neoplasms 15 | 471
acute myeloid leukemia 15 | 785
adrenocortical carcinoma 15 | 1,427
cystic fibrosis 15 | 1,670
group 3 medulloblastoma 15 | 2,254
breast carcinoma 14 | 1,614
colon cancer 14 | 1,475
cutaneous lupus erythematosus 14 | 1,056
Liver carcinoma 13 | 217
esophageal adenocarcinoma 13 | 737
spina bifida 13 | 1,064
Colorectal Neoplasms 12 | 217
Parkinson's disease 12 | 364
Rheumatoid Arthritis 12 | 1,170
Vascular disease 12 | 281
gastric carcinoma 12 | 832
Duchenne muscular dystrophy 11 | 602
Kidney disease 11 | 397
aldosterone-producing adenoma 11 | 664
atypical teratoid/rhabdoid tumor 11 | 1,095
non primary Sjogren syndrome sicca 11 | 840
posterior fossa group B ependymoma 11 | 1,530
sonic hedgehog group medulloblastoma 11 | 1,482
Hypersensitivity reaction type II disease 10 | 235
Lung Neoplasms 10 | 171
Neoplasm Metastasis 10 | 138
Obesity 10 | 616
primary Sjogren syndrome 10 | 788
Amyotrophic Lateral Sclerosis 9 | 432
Liver disease 9 | 219
Lung disease 9 | 136
Multiple Sclerosis 9 | 498
Toxic encephalopathy 9 | 131
chronic lymphocytic leukemia 9 | 244
gastric cancer 9 | 436
tuberculosis and treatment for 6 months 9 | 686
Adenocarcinoma 8 | 115
Arthritis 8 | 248
Colonic Neoplasms 8 | 126
Diabetes Mellitus, Experimental 8 | 106
Esophageal Neoplasms 8 | 67
IGA Glomerulonephritis 8 | 454
Melanoma 8 | 261
Neoplastic Cell Transformation 8 | 81
Pancreatic Neoplasm 8 | 79
Peripheral Neuropathy 8 | 303
Schizophrenia 8 | 503
Stomach Neoplasms 8 | 282
mucosa-associated lymphoid tissue lymphoma 8 | 480
non-small cell lung carcinoma 8 | 413
Endometriosis 7 | 535

Tissue

Blood and immune system 167 | 17,994
Digestive Tract 167 | 18,472
Female tissues 167 | 18,646
Liver and Pancreas 167 | 18,135
Male tissues 167 | 17,968
Nervous System 167 | 18,560
Urinary Tract 167 | 18,443
Endocrine System 166 | 18,511
Respiratory system 166 | 17,483
Cardiovascular System 165 | 17,957
Skin and soft tissues 165 | 18,114

Target Family

Non-IDG 90 | 11,969
Enzyme 52 | 4,146
Kinase 16 | 634
Transcription Factor 9 | 1,400

Reactome Pathway

Apoptosis 167 | 167
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bcl-2-like protein 11 BCL2L11 Tbio Non-IDG -3.14287 1340.6 903
Lymphocyte antigen 96 LY96 Tbio Non-IDG -2.73333 490.7 314
DNA-binding protein SATB1 SATB1 Tbio Transcription Factor -2.24334 197.9 293
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.55872 362.3 648
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.73539 525.6 142
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
Plakophilin-1 PKP1 Tbio Non-IDG -1.85135 73.8 91
Spectrin alpha chain, non-erythrocytic 1 SPTAN1 Tbio Non-IDG -2.41058 258.0 266
Calcineurin subunit B type 1 PPP3R1 Tbio Non-IDG -2.56314 362.9 113
Death-associated protein kinase 3 DAPK3 Tchem Kinase -1.64328 50.9 237