Development Level

Tbio 100 | 10,625
Tchem 58 | 1,890
Tclin 8 | 602
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 11 | 633
abnormal retina morphology 3 | 100
abnormal bone mineralization 2 | 55
decreased body length 2 | 108
decreased body weight 2 | 174
embryonic lethality prior to t... 2 | 187
hydrops fetalis 2 | 22
increased bone mineral density 2 | 52
increased circulating alkaline... 2 | 119
persistence of hyaloid vascula... 2 | 22
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat/ hair morphology 1 | 18
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal vitreous body morphol... 1 | 7
decreased Ly6C high monocyte n... 1 | 18
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased lean body mass 1 | 195
decreased neutrophil cell numb... 1 | 37
decreased total retina thickne... 1 | 20
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
increased Ly6C low monocyte nu... 1 | 8
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased circulating LDL chol... 1 | 15
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased granulocyte number 1 | 8
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
male infertility 1 | 62
oligodactyly 1 | 14
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytosis 1 | 23

Disease

ovarian cancer 111 | 8,484
psoriasis 85 | 6,685
osteosarcoma 82 | 7,933
lung cancer 77 | 4,466
Cancer 75 | 2,346
glioblastoma 65 | 5,572
medulloblastoma, large-cell 59 | 6,234
Breast cancer 47 | 3,094
atypical teratoid / rhabdoid tumor 47 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
Multiple myeloma 41 | 1,327
malignant mesothelioma 40 | 3,162
lung adenocarcinoma 35 | 2,713
non-small cell lung cancer 35 | 2,798
pilocytic astrocytoma 35 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,988
oligodendroglioma 32 | 2,849
diabetes mellitus 31 | 1,663
pancreatic cancer 31 | 2,300
invasive ductal carcinoma 29 | 2,950
pediatric high grade glioma 29 | 2,712
dermatomyositis 28 | 933
ependymoma 28 | 2,514
lung carcinoma 28 | 2,844
subependymal giant cell astrocytoma 28 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,956
interstitial cystitis 25 | 2,299
primitive neuroectodermal tumor 25 | 3,031
group 4 medulloblastoma 24 | 1,875
Carcinoma 23 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795
Waldenstrons macroglobulinemia 22 | 765
ulcerative colitis 22 | 2,087
astrocytic glioma 21 | 2,241
juvenile dermatomyositis 20 | 1,189
Pick disease 19 | 1,893
adult high grade glioma 19 | 2,148
pituitary cancer 19 | 1,972
primary pancreatic ductal adenocarcinoma 19 | 1,271
HIV Infections 18 | 100
astrocytoma 18 | 1,493
tuberculosis 18 | 1,557
Alzheimer's disease 17 | 644
medulloblastoma 17 | 1,524
posterior fossa group A ependymoma 17 | 1,511
acute quadriplegic myopathy 16 | 1,157
ductal carcinoma in situ 16 | 1,745
Mammary Neoplasms 15 | 410
Prostatic Neoplasms 15 | 471
acute myeloid leukemia 15 | 780
adrenocortical carcinoma 15 | 1,427
cystic fibrosis 15 | 1,665
group 3 medulloblastoma 15 | 2,254
hepatocellular carcinoma 15 | 532
breast carcinoma 14 | 1,614
colon cancer 14 | 1,475
cutaneous lupus erythematosus 14 | 1,056
Liver carcinoma 13 | 217
Rheumatoid Arthritis 13 | 1,160
esophageal adenocarcinoma 13 | 737
spina bifida 13 | 1,064
Colorectal Neoplasms 12 | 217
Parkinson's disease 12 | 364
Vascular disease 12 | 281
gastric carcinoma 12 | 832
Duchenne muscular dystrophy 11 | 602
Kidney disease 11 | 396
aldosterone-producing adenoma 11 | 664
atypical teratoid/rhabdoid tumor 11 | 1,095
non primary Sjogren syndrome sicca 11 | 840
posterior fossa group B ependymoma 11 | 1,530
primary Sjogren syndrome 11 | 789
sonic hedgehog group medulloblastoma 11 | 1,482
Hypersensitivity reaction type II disease 10 | 235
Lung Neoplasms 10 | 171
Neoplasm Metastasis 10 | 138
Obesity 10 | 616
Amyotrophic Lateral Sclerosis 9 | 431
Chronic Lymphocytic Leukemia 9 | 242
Liver disease 9 | 219
Lung disease 9 | 132
Multiple Sclerosis 9 | 498
Toxic encephalopathy 9 | 131
tuberculosis and treatment for 6 months 9 | 686
Adenocarcinoma 8 | 115
Arthritis 8 | 248
Colonic Neoplasms 8 | 126
Diabetes Mellitus, Experimental 8 | 106
Esophageal Neoplasms 8 | 67
IGA Glomerulonephritis 8 | 454
Melanoma 8 | 261
Neoplastic Cell Transformation 8 | 81
Pancreatic Neoplasm 8 | 79
Peripheral Neuropathy 8 | 303
Polycystic Ovary Syndrome 8 | 332
Schizophrenia 8 | 501
Stomach Neoplasms 8 | 282
gastric cancer 8 | 430
mucosa-associated lymphoid tissue lymphoma 8 | 480
non-small cell lung carcinoma 8 | 413

Tissue

Blood and immune system 168 | 17,995
Digestive Tract 168 | 18,473
Female tissues 168 | 18,647
Liver and Pancreas 168 | 18,136
Male tissues 168 | 17,969
Nervous System 168 | 18,561
Urinary Tract 168 | 18,444
Endocrine System 167 | 18,512
Respiratory system 167 | 17,484
Cardiovascular System 166 | 17,958
Skin and soft tissues 166 | 18,115

Target Family

Non-IDG 90 | 11,971
Enzyme 53 | 4,146
Kinase 16 | 634
Transcription Factor 9 | 1,400

Reactome Pathway

Apoptosis 168 | 168
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.65303 525.6 142
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.27492 2052.7 1794
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Netrin receptor UNC5B UNC5B Tbio Non-IDG -1.68718 46.2 106
Cytochrome c CYCS Tbio Non-IDG -3.73952 4771.4 630
Toll-like receptor 3 TLR3 Tchem Non-IDG -3.00214 1147.2 751