Development Level

Tbio 57 | 10,625
Tchem 9 | 1,890
Tdark 6 | 7,003
Tclin 1 | 602

IMPC Phenotype

preweaning lethality, complete... 6 | 633
decreased lean body mass 3 | 195
decreased bone mineral content 2 | 157
increased lean body mass 2 | 107
abnormal coping response 1 | 12
abnormal gait 1 | 51
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased grip strength 1 | 123
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
increased circulating alkaline... 1 | 119

Disease

ovarian cancer 49 | 8,491
lung cancer 41 | 4,473
osteosarcoma 36 | 7,933
medulloblastoma, large-cell 34 | 6,234
glioblastoma 30 | 5,572
psoriasis 28 | 6,685
dermatomyositis 23 | 966
atypical teratoid / rhabdoid tumor 22 | 4,369
Cancer 20 | 2,346
group 3 medulloblastoma 20 | 2,254
pediatric high grade glioma 18 | 2,712
Multiple myeloma 17 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
Carcinoma 16 | 2,147
Breast cancer 14 | 3,098
ependymoma 14 | 2,514
pilocytic astrocytoma 14 | 3,086
malignant mesothelioma 13 | 3,163
oligodendroglioma 13 | 2,849
primitive neuroectodermal tumor 13 | 3,031
subependymal giant cell astrocytoma 13 | 2,287
Influenza 12 | 142
astrocytic glioma 12 | 2,241
non-small cell lung cancer 12 | 2,798
pancreatic cancer 12 | 2,300
invasive ductal carcinoma 11 | 2,950
juvenile dermatomyositis 11 | 1,189
Pick disease 10 | 1,893
Waldenstrons macroglobulinemia 10 | 764
cutaneous lupus erythematosus 10 | 1,056
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
lung carcinoma 10 | 2,844
astrocytoma 9 | 1,493
tuberculosis 9 | 1,563
Amyotrophic Lateral Sclerosis 8 | 432
group 4 medulloblastoma 8 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
lung adenocarcinoma 8 | 2,714
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
sonic hedgehog group medulloblastoma 8 | 1,482
ulcerative colitis 8 | 2,087
Atopic dermatitis 7 | 944
Multiple Sclerosis 7 | 498
Rheumatoid Arthritis 7 | 1,170
acute myeloid leukemia 7 | 785
breast carcinoma 7 | 1,614
cystic fibrosis 7 | 1,670
primary Sjogren syndrome 7 | 788
systemic lupus erythematosus 7 | 172
acute quadriplegic myopathy 6 | 1,157
diabetes mellitus 6 | 1,663
interstitial cystitis 6 | 2,299
Hepatitis C 5 | 90
adult high grade glioma 5 | 2,148
atypical teratoid/rhabdoid tumor 5 | 1,095
nasopharyngeal carcinoma 5 | 1,056
posterior fossa group A ependymoma 5 | 1,511
primary pancreatic ductal adenocarcinoma 5 | 1,271
progressive supranuclear palsy 5 | 674
Alzheimer's disease 4 | 644
colon cancer 4 | 1,475
ductal carcinoma in situ 4 | 1,745
hereditary spastic paraplegia 4 | 313
medulloblastoma 4 | 1,524
pancreatic carcinoma 4 | 567
spina bifida 4 | 1,064
Encephalitis 3 | 54
HIV Infections 3 | 99
Leukemia, Myelocytic, Acute 3 | 113
Lung disease 3 | 136
Myocardial Ischemia 3 | 169
Prostatic Neoplasms 3 | 471
Severe acute respiratory syndrome 3 | 26
Vascular disease 3 | 281
active Crohn's disease 3 | 918
adrenocortical carcinoma 3 | 1,427
aldosterone-producing adenoma 3 | 664
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 832
hepatocellular carcinoma 3 | 550
inflammatory breast cancer 3 | 404
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
Arthritis 2 | 248
Disease Progression 2 | 125
Down syndrome 2 | 548
Endometriosis 2 | 535
Gaucher disease type 1 2 | 171
Hypersensitivity reaction type II disease 2 | 235
Hypertension 2 | 293
IGA Glomerulonephritis 2 | 454
Leukemia 2 | 88
Melanoma 2 | 261
Muscle Weakness 2 | 92
Neoplasm Metastasis 2 | 138
Parkinson's disease 2 | 364
Stomach Neoplasms 2 | 282
non-small cell lung carcinoma 2 | 413
tuberculosis and treatment for 3 months 2 | 327
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 73 | 17,994
Cardiovascular System 73 | 17,957
Endocrine System 73 | 18,511
Female tissues 73 | 18,646
Liver and Pancreas 73 | 18,135
Male tissues 73 | 17,968
Nervous System 73 | 18,560
Digestive Tract 72 | 18,472
Respiratory system 72 | 17,483
Skin and soft tissues 72 | 18,114
Urinary Tract 72 | 18,443

Target Family

Non-IDG 56 | 11,969
Enzyme 12 | 4,146
Kinase 3 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

Antiviral mechanism by IFN-sti... 73 | 73
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.63849 5.23 31
Eukaryotic translation initiation factor 4 gamma 3 EIF4G3 Tbio Non-IDG -1.29237 17.0 113
Nuclear pore complex protein Nup85 NUP85 Tbio Non-IDG -1.18826 15.9 128
Ubl carboxyl-terminal hydrolase 18 USP18 Tbio Enzyme -1.77723 68.2 69
Eukaryotic translation initiation factor 4E type 3 EIF4E3 Tbio Non-IDG -0.94340 7.46 56
Ubiquitin-like protein ISG15 ISG15 Tbio Non-IDG -2.43466 301.8 323
Signal transducer and activator of transcription 1-alpha/beta STAT1 Tchem Transcription Factor -3.29893 1889.3 1357
Aladin AAAS Tbio Non-IDG -3.23885 1684.2 137
Importin subunit alpha-8 KPNA7 Tdark Non-IDG -0.71401 6.13 33
Nucleoporin Nup43 NUP43 Tdark Non-IDG 0.12 1.06 119