Development Level

Tbio 56 | 11,445
Tchem 9 | 1,598
Tdark 6 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal gait 2 | 69
decreased bone mineral content 2 | 151
decreased circulating chloride... 2 | 30
decreased red blood cell distr... 2 | 41
embryonic lethality prior to o... 2 | 239
increased lymphocyte cell numb... 2 | 32
abnormal bone structure 1 | 187
abnormal heart morphology 1 | 162
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased circulating alkaline... 1 | 122
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
prenatal lethality 1 | 28

Disease

Carcinoma 54 | 11,493
ovarian cancer 49 | 8,520
lung cancer 40 | 4,740
osteosarcoma 35 | 7,950
medulloblastoma, large-cell 33 | 6,241
glioblastoma 30 | 5,792
group 3 medulloblastoma 28 | 4,104
psoriasis 28 | 6,694
atypical teratoid / rhabdoid tumor 26 | 5,112
dermatomyositis 23 | 966
Cancer 20 | 2,499
ependymoma 19 | 4,679
Kidney cancer 17 | 2,613
Multiple myeloma 17 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Breast cancer 16 | 3,578
adult high grade glioma 16 | 3,801
Astrocytoma, Pilocytic 14 | 3,081
astrocytic glioma 14 | 2,597
malignant mesothelioma 13 | 3,232
oligodendroglioma 13 | 2,850
primitive neuroectodermal tumor 13 | 3,035
subependymal giant cell astrocytoma 13 | 2,287
Influenza 12 | 142
non-small cell lung cancer 12 | 2,890
pancreatic cancer 12 | 2,398
invasive ductal carcinoma 11 | 2,951
juvenile dermatomyositis 11 | 1,187
tuberculosis 11 | 2,010
Pick disease 10 | 1,894
Waldenstrons macroglobulinemia 10 | 765
cutaneous lupus erythematosus 10 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
lung carcinoma 10 | 2,843
Amyotrophic lateral sclerosis 9 | 451
Influenza, Human 9 | 51
Multiple Sclerosis 8 | 540
group 4 medulloblastoma 8 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
lung adenocarcinoma 8 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Atopic dermatitis 7 | 952
Microphthalmia with limb anomalies 7 | 40
Rheumatoid arthritis 7 | 1,191
Systemic lupus erythematosus 7 | 194
acute myeloid leukemia 7 | 783
astrocytoma 7 | 1,146
breast carcinoma 7 | 1,638
cystic fibrosis 7 | 1,696
pediatric high grade glioma 7 | 1,064
Autosomal recessive predisposition 6 | 1,442
acute quadriplegic myopathy 6 | 1,158
diabetes mellitus 6 | 1,728
interstitial cystitis 6 | 2,312
primary Sjogren syndrome 6 | 735
ulcerative colitis 6 | 1,819
Hepatitis C 5 | 94
nasopharyngeal carcinoma 5 | 1,058
primary pancreatic ductal adenocarcinoma 5 | 1,109
progressive supranuclear palsy 5 | 676
Alzheimer's disease 4 | 658
Anemia 4 | 365
Schizophrenia 4 | 1,160
colon cancer 4 | 1,478
ductal carcinoma in situ 4 | 1,745
hereditary spastic paraplegia 4 | 318
pancreatic carcinoma 4 | 562
spina bifida 4 | 1,074
Asthma 3 | 385
Cleft Palate 3 | 271
Encephalitis 3 | 64
HIV Infections 3 | 102
Hepatitis 3 | 67
Leukemia, Myelocytic, Acute 3 | 120
Liver cancer 3 | 604
Lung disease 3 | 142
Melanoma 3 | 711
Myocardial Ischemia 3 | 169
Neoplasm Metastasis 3 | 168
Obesity 3 | 678
Short stature 3 | 531
Uranostaphyloschisis 3 | 167
Vascular disease 3 | 319
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
adrenocortical carcinoma 3 | 1,428
aldosterone-producing adenoma 3 | 665
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 807
hepatocellular carcinoma 3 | 547
pituitary cancer 3 | 1,972
sonic hedgehog group medulloblastoma 3 | 467
Arthritis 2 | 290
Bipolar Disorder 2 | 666
Endometriosis 2 | 540
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Hypersensitivity reaction type II disease 2 | 253
Leukemia 2 | 104
Seizures 2 | 596

Tissue

Digestive Tract 71 | 17,369
Respiratory system 71 | 16,393
Blood and immune system 70 | 16,909
Endocrine System 70 | 18,159
Female tissues 70 | 17,400
Liver and Pancreas 70 | 16,750
Nervous System 70 | 16,725
Cardiovascular System 69 | 15,192
Male tissues 69 | 17,142
Skin and soft tissues 69 | 17,230
Urinary Tract 69 | 16,678

Target Family

Non-IDG 55 | 12,091
Enzyme 12 | 4,145
Kinase 3 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

Antiviral mechanism by IFN-sti... 72 | 72
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
E3 ISG15--protein ligase HERC5 HERC5 Tbio Enzyme -1.63055 44.5 57
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Nuclear pore complex protein Nup85 NUP85 Tbio Non-IDG -1.23703 17.9 139
Interferon-induced GTP-binding protein Mx2 MX2 Tbio Non-IDG -2.62530 417.4 66
Nuclear envelope pore membrane protein POM 121C POM121C Tdark Non-IDG 0.27 0.57 0
Nuclear pore complex protein Nup205 NUP205 Tbio Non-IDG -0.62172 3.73 27
Nuclear pore complex protein Nup153 NUP153 Tbio Non-IDG -2.14396 129.9 100