Development Level

Tbio 210 | 10,625
Tdark 63 | 7,003
Tchem 23 | 1,890
Tclin 6 | 602

IMPC Term

preweaning lethality, complete... 14 | 633
preweaning lethality, incomple... 12 | 260
abnormal behavior 11 | 226
decreased lean body mass 11 | 195
decreased bone mineral content 10 | 157
decreased grip strength 9 | 123
decreased bone mineral density 7 | 126
increased or absent threshold ... 7 | 128
decreased heart weight 6 | 44
decreased body length 5 | 108
abnormal bone structure 4 | 131
decreased circulating triglyce... 4 | 83
decreased total body fat amoun... 4 | 186
embryonic lethality prior to t... 4 | 187
hypoactivity 4 | 89
increased mean corpuscular vol... 4 | 91
male infertility 4 | 62
short tibia 4 | 82
abnormal embryo size 3 | 112
decreased body weight 3 | 174
decreased circulating alanine ... 3 | 53
decreased hemoglobin content 3 | 53
decreased startle reflex 3 | 48
embryonic lethality prior to o... 3 | 148
abnormal eye morphology 2 | 38
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
abnormal retina morphology 2 | 100
abnormal spleen morphology 2 | 36
absent startle reflex 2 | 15
anophthalmia 2 | 20
cardiovascular system phenotyp... 2 | 35
decreased circulating HDL chol... 2 | 77
decreased circulating amylase ... 2 | 24
decreased circulating aspartat... 2 | 27
decreased circulating chloride... 2 | 32
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased eosinophil cell numb... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
embryonic growth retardation 2 | 28
enlarged spleen 2 | 26
hyperactivity 2 | 108
increased NK cell number 2 | 19
increased circulating HDL chol... 2 | 63
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased effector memory CD8-... 2 | 14
increased exploration in new e... 2 | 56
increased grip strength 2 | 83
increased heart rate 2 | 17
increased heart weight 2 | 37
increased lean body mass 2 | 107
increased monocyte cell number 2 | 27
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
small liver 2 | 8
tremors 2 | 34
trunk curl 2 | 15
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal coping response 1 | 12
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased cardiac muscle contr... 1 | 5
decreased effector memory CD8-... 1 | 24
decreased heart rate 1 | 10
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
dilated heart left ventricle 1 | 10
female infertility 1 | 34
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased mean platelet volume 1 | 19
increased rib number 1 | 41
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
shortened ST segment 1 | 9
small thymus 1 | 11
straub tail 1 | 26
thrombocytopenia 1 | 46

Disease

ovarian cancer 187 | 8,484
osteosarcoma 143 | 7,933
medulloblastoma, large-cell 115 | 6,234
psoriasis 109 | 6,685
glioblastoma 100 | 5,572
atypical teratoid / rhabdoid tumor 86 | 4,369
lung cancer 75 | 4,466
Multiple myeloma 65 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,289
astrocytic glioma 50 | 2,241
Breast cancer 49 | 3,094
ependymoma 48 | 2,514
oligodendroglioma 47 | 2,849
primitive neuroectodermal tumor 47 | 3,031
adult high grade glioma 43 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,988
pilocytic astrocytoma 42 | 3,086
malignant mesothelioma 41 | 3,162
subependymal giant cell astrocytoma 40 | 2,287
Pick disease 38 | 1,893
pediatric high grade glioma 35 | 2,712
Cancer 34 | 2,346
juvenile dermatomyositis 34 | 1,189
group 4 medulloblastoma 33 | 1,875
medulloblastoma 33 | 1,524
Carcinoma 31 | 2,147
invasive ductal carcinoma 31 | 2,950
non-small cell lung cancer 31 | 2,798
pancreatic cancer 30 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,795
group 3 medulloblastoma 28 | 2,254
ulcerative colitis 28 | 2,087
dermatomyositis 27 | 933
lung carcinoma 27 | 2,844
lung adenocarcinoma 26 | 2,713
spina bifida 25 | 1,064
acute quadriplegic myopathy 24 | 1,157
Rheumatoid Arthritis 23 | 1,160
tuberculosis and treatment for 6 months 23 | 686
Waldenstrons macroglobulinemia 22 | 765
tuberculosis 21 | 1,557
non primary Sjogren syndrome sicca 20 | 840
astrocytoma 19 | 1,493
interstitial cystitis 19 | 2,299
pituitary cancer 19 | 1,972
primary pancreatic ductal adenocarcinoma 19 | 1,271
breast carcinoma 18 | 1,614
diabetes mellitus 18 | 1,663
posterior fossa group A ependymoma 18 | 1,511
sonic hedgehog group medulloblastoma 18 | 1,482
adrenocortical carcinoma 17 | 1,427
active Crohn's disease 16 | 918
posterior fossa group B ependymoma 16 | 1,530
primary Sjogren syndrome 16 | 789
HIV Infections 15 | 100
Atopic dermatitis 14 | 944
Intellectual disability 14 | 573
Parkinson's disease 14 | 364
acute myeloid leukemia 14 | 780
cutaneous lupus erythematosus 12 | 1,056
cystic fibrosis 12 | 1,665
esophageal adenocarcinoma 12 | 737
gastric carcinoma 12 | 832
hepatocellular carcinoma 12 | 532
progressive supranuclear palsy 12 | 674
Amyotrophic Lateral Sclerosis 10 | 431
Duchenne muscular dystrophy 9 | 602
IGA Glomerulonephritis 9 | 454
Neurodegenerative disease 9 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
colon cancer 9 | 1,475
ductal carcinoma in situ 9 | 1,745
Multiple Sclerosis 8 | 498
chronic rhinosinusitis 8 | 512
sarcoidosis 8 | 358
tuberculosis and treatment for 3 months 8 | 327
aldosterone-producing adenoma 7 | 664
atypical teratoid/rhabdoid tumor 7 | 1,095
gastric cancer 7 | 430
nasopharyngeal carcinoma 7 | 1,056
Alzheimer's disease 6 | 644
Gaucher disease type 1 6 | 171
inflammatory breast cancer 6 | 404
non diabetic and post-ischemic heart failure 6 | 200
Autistic Disorder 5 | 320
Endometriosis 5 | 535
Hypertension 5 | 287
Liddle syndrome 5 | 14
Mammary Neoplasms 5 | 410
Mantle cell lymphoma 5 | 18
Muscular atrophy 5 | 67
Prostatic Neoplasms 5 | 471
Stevens-Johnson syndrome 5 | 78
glioblastoma multiforme 5 | 347
hereditary spastic paraplegia 5 | 313
interstitial lung disease 5 | 291
Down syndrome 4 | 548
Obesity 4 | 616
pancreatic carcinoma 4 | 567

Tissue

Blood and immune system 301 | 17,995
Female tissues 301 | 18,647
Nervous System 301 | 18,561
Urinary Tract 301 | 18,444
Digestive Tract 300 | 18,473
Liver and Pancreas 300 | 18,136
Cardiovascular System 299 | 17,958
Endocrine System 299 | 18,512
Male tissues 299 | 17,969
Skin and soft tissues 299 | 18,115
Respiratory system 295 | 17,484

Target Family

Non-IDG 156 | 11,971
Enzyme 144 | 4,146
Transcription Factor 2 | 1,400

Reactome Pathway

Antigen processing: Ubiquitina... 302 | 302
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.08055 124.6 194
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
Cullin-5 CUL5 Tbio Non-IDG -1.93258 89.1 172
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56439 38.8 140
F-box/LRR-repeat protein 13 FBXL13 Tdark Non-IDG -0.47349 2.81 66
NEDD4-like E3 ubiquitin-protein ligase WWP1 WWP1 Tbio Enzyme -1.57709 42.8 121
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
F-box/WD repeat-containing protein 10 FBXW10 Tdark Non-IDG -0.81410 6.42 42
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
F-box only protein 27 FBXO27 Tbio Non-IDG -0.17724 1.07 68