Development Level

Tbio 236 | 11,651
Tdark 58 | 6,593
Tchem 6 | 1,388
Tclin 6 | 612

IMPC Phenotype

preweaning lethality, complete... 21 | 979
preweaning lethality, incomple... 15 | 499
abnormal behavior 13 | 298
decreased bone mineral content 9 | 151
embryonic lethality prior to t... 8 | 278
decreased bone mineral density 7 | 126
male infertility 7 | 123
decreased body weight 6 | 161
decreased lean body mass 6 | 135
abnormal bone structure 5 | 187
abnormal embryo size 5 | 220
decreased startle reflex 5 | 75
hypoactivity 5 | 132
increased mean corpuscular vol... 5 | 92
short tibia 5 | 97
abnormal heart morphology 4 | 162
decreased body length 4 | 101
decreased circulating glucose ... 4 | 126
decreased hemoglobin content 4 | 68
decreased prepulse inhibition 4 | 82
decreased vertical activity 4 | 208
embryonic lethality prior to o... 4 | 239
enlarged heart 4 | 210
female infertility 4 | 60
increased mean platelet volume 4 | 45
increased or absent threshold ... 4 | 101
increased total body fat amoun... 4 | 134
abnormal gait 3 | 69
decreased blood urea nitrogen ... 3 | 51
decreased circulating alanine ... 3 | 47
decreased circulating chloride... 3 | 30
decreased circulating creatini... 3 | 39
decreased circulating total pr... 3 | 49
decreased circulating triglyce... 3 | 79
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased heart left ventricle... 3 | 28
decreased lymphocyte cell numb... 3 | 83
decreased neutrophil cell numb... 3 | 42
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
enlarged spleen 3 | 41
hyperactivity 3 | 148
increased circulating chloride... 3 | 41
increased circulating creatini... 3 | 38
increased lymphocyte cell numb... 3 | 32
abnormal behavioral response t... 2 | 66
abnormal kidney morphology 2 | 65
abnormal skin morphology 2 | 50
abnormal spleen morphology 2 | 55
abnormal vocalization 2 | 21
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
decreased caudal vertebrae num... 2 | 53
decreased circulating aspartat... 2 | 34
decreased circulating fructosa... 2 | 30
decreased circulating iron lev... 2 | 32
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased red blood cell distr... 2 | 41
dilated heart left ventricle 2 | 11
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased body length 2 | 32
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased fasted circulating g... 2 | 76
increased heart rate 2 | 23
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased prepulse inhibition 2 | 32
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
prenatal lethality 2 | 28
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small liver 2 | 8
thin ventricular wall 2 | 24
thrombocytopenia 2 | 56
tremors 2 | 39
trunk curl 2 | 16
abnormal heart left ventricle ... 1 | 16
abnormal retina morphology 1 | 71
absent spleen 1 | 3
decreased circulating amylase ... 1 | 28
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased total retina thickne... 1 | 17
increased anti-nuclear antigen... 1 | 19
increased bone mineral density 1 | 72
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42

Disease

Carcinoma 190 | 11,493
ovarian cancer 190 | 8,520
osteosarcoma 145 | 7,950
medulloblastoma, large-cell 115 | 6,241
psoriasis 108 | 6,694
glioblastoma 102 | 5,792
atypical teratoid / rhabdoid tumor 92 | 5,112
lung cancer 82 | 4,740
ependymoma 71 | 4,679
Multiple myeloma 67 | 1,332
adult high grade glioma 67 | 3,801
Breast cancer 57 | 3,578
astrocytic glioma 55 | 2,597
group 3 medulloblastoma 55 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,291
oligodendroglioma 48 | 2,850
primitive neuroectodermal tumor 47 | 3,035
Kidney cancer 45 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,955
Astrocytoma, Pilocytic 42 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,989
malignant mesothelioma 42 | 3,232
subependymal giant cell astrocytoma 41 | 2,287
Cancer 38 | 2,499
Pick disease 38 | 1,894
juvenile dermatomyositis 34 | 1,187
non-small cell lung cancer 34 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,962
group 4 medulloblastoma 33 | 1,855
invasive ductal carcinoma 32 | 2,951
pancreatic cancer 32 | 2,398
tuberculosis 32 | 2,010
dermatomyositis 28 | 966
lung carcinoma 27 | 2,843
lung adenocarcinoma 25 | 2,716
spina bifida 25 | 1,074
acute quadriplegic myopathy 24 | 1,158
Waldenstrons macroglobulinemia 23 | 765
Rheumatoid arthritis 22 | 1,191
non primary Sjogren syndrome sicca 21 | 891
ulcerative colitis 21 | 1,819
diabetes mellitus 20 | 1,728
interstitial cystitis 19 | 2,312
pituitary cancer 19 | 1,972
breast carcinoma 18 | 1,638
Intellectual disability 17 | 1,016
adrenocortical carcinoma 17 | 1,428
astrocytoma 17 | 1,146
tuberculosis and treatment for 6 months 17 | 409
active Crohn's disease 16 | 922
primary Sjogren syndrome 16 | 735
Autosomal recessive predisposition 15 | 1,442
HIV Infections 15 | 102
Parkinson's disease 15 | 392
acute myeloid leukemia 15 | 783
medulloblastoma 15 | 720
primary pancreatic ductal adenocarcinoma 15 | 1,109
Atopic dermatitis 14 | 952
cutaneous lupus erythematosus 12 | 1,057
cystic fibrosis 12 | 1,696
esophageal adenocarcinoma 12 | 737
gastric carcinoma 12 | 807
hepatocellular carcinoma 12 | 547
Amyotrophic lateral sclerosis 11 | 451
pediatric high grade glioma 11 | 1,064
progressive supranuclear palsy 11 | 676
sonic hedgehog group medulloblastoma 11 | 467
Duchenne muscular dystrophy 9 | 601
Dull intelligence 9 | 645
Liver cancer 9 | 604
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Multiple Sclerosis 9 | 540
Poor school performance 9 | 645
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
colon cancer 9 | 1,478
ductal carcinoma in situ 9 | 1,745
Neurodegenerative disease 8 | 414
active ulcerative colitis 8 | 764
chronic rhinosinusitis 8 | 512
sarcoidosis 8 | 370
Liver Cirrhosis, Experimental 7 | 769
aldosterone-producing adenoma 7 | 665
gastric cancer 7 | 459
nasopharyngeal carcinoma 7 | 1,058
posterior fossa group A ependymoma 7 | 468
Alzheimer's disease 6 | 658
Attention deficit hyperactivity disorder 6 | 278
Bipolar Disorder 6 | 666
Endometrial cancer 6 | 311
Epilepsy 6 | 792
Gaucher disease type 1 6 | 180
Hypertension 6 | 396
Short stature 6 | 531
non diabetic and post-ischemic heart failure 6 | 200
Endometriosis 5 | 540
Kidney disease 5 | 430
Prostatic Neoplasms 5 | 495
Schizophrenia 5 | 1,160

Tissue

Endocrine System 304 | 18,159
Female tissues 298 | 17,400
Skin and soft tissues 298 | 17,230
Digestive Tract 297 | 17,369
Male tissues 297 | 17,142
Urinary Tract 297 | 16,678
Nervous System 296 | 16,725
Respiratory system 295 | 16,393
Blood and immune system 294 | 16,909
Cardiovascular System 293 | 15,192
Liver and Pancreas 293 | 16,750

Target Family

Non-IDG 162 | 12,091
Enzyme 142 | 4,145
Transcription Factor 2 | 1,400

Reactome Pathway

Antigen processing: Ubiquitina... 306 | 306
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Tripeptidyl-peptidase 2 TPP2 Tbio Enzyme -1.97332 108.2 72
E3 ubiquitin-protein ligase RNF182 RNF182 Tdark Enzyme 0.06 0.73 104
Probable E3 ubiquitin-protein ligase HERC1 HERC1 Tbio Enzyme -1.02371 5.75 39
Ankyrin repeat and SOCS box protein 10 ASB10 Tbio Non-IDG -0.85286 7.76 117
E3 ubiquitin-protein ligase DZIP3 DZIP3 Tbio Enzyme -0.24304 1.68 116
F-box/LRR-repeat protein 7 FBXL7 Tbio Non-IDG -0.80631 6.84 53
Ankyrin repeat and SOCS box protein 13 ASB13 Tdark Non-IDG 0.78 0.14 85
Ankyrin repeat and SOCS box protein 6 ASB6 Tdark Non-IDG -0.23045 2.25 53