Development Level

Tdark 58 | 7,003
Tchem 17 | 1,890
Tbio 15 | 10,625
Tclin 5 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

decreased body weight 2 | 174
decreased circulating choleste... 2 | 85
abnormal bone mineralization 1 | 55
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal posture 1 | 5
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal testis morphology 1 | 30
decreased B cell number 1 | 30
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased lean body mass 1 | 195
decreased mature B cell number 1 | 25
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
small epididymis 1 | 3
small testis 1 | 37

Disease

osteosarcoma 37 | 7,933
interstitial cystitis 24 | 2,299
lung cancer 24 | 4,466
ovarian cancer 24 | 8,484
psoriasis 24 | 6,685
ulcerative colitis 21 | 2,087
Cancer 20 | 2,346
medulloblastoma, large-cell 17 | 6,234
primary Sjogren syndrome 16 | 789
subependymal giant cell astrocytoma 16 | 2,287
glioblastoma 15 | 5,572
tuberculosis 15 | 1,557
pancreatic cancer 13 | 2,300
cutaneous lupus erythematosus 12 | 1,056
lung adenocarcinoma 12 | 2,713
periodontitis 12 | 269
Carcinoma 11 | 2,147
Multiple myeloma 11 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
lung carcinoma 11 | 2,844
chronic lymphosyte leukemia 10 | 232
cystic fibrosis 10 | 1,665
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
invasive ductal carcinoma 10 | 2,950
non-small cell lung cancer 10 | 2,798
Pick disease 8 | 1,893
Breast cancer 7 | 3,094
Rheumatoid Arthritis 7 | 1,160
adult high grade glioma 7 | 2,148
atypical teratoid / rhabdoid tumor 7 | 4,369
colon cancer 7 | 1,475
group 4 medulloblastoma 7 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
juvenile dermatomyositis 7 | 1,189
malignant mesothelioma 7 | 3,162
pilocytic astrocytoma 7 | 3,086
primary pancreatic ductal adenocarcinoma 7 | 1,271
Amebiasis 6 | 22
diabetes mellitus 6 | 1,663
esophageal adenocarcinoma 6 | 737
oligodendroglioma 6 | 2,849
pediatric high grade glioma 6 | 2,712
primitive neuroectodermal tumor 6 | 3,031
Agammaglobulinemia 5 | 24
Leukemia 5 | 88
Lymphoma 5 | 56
Waldenstrons macroglobulinemia 5 | 765
astrocytoma 5 | 1,493
cystic fibrosis and chronic rhinosinusitis 5 | 213
nasopharyngeal carcinoma 5 | 1,056
non-small cell lung carcinoma 5 | 413
pituitary cancer 5 | 1,972
spina bifida 5 | 1,064
Allergic hypersensitivity disease 4 | 123
Blastic phase chronic myeloid leukemia 4 | 58
Chronic Myelocytic Leukemia Accelerated Phase 4 | 59
Macroglobulinemia 4 | 17
Multiple Sclerosis 4 | 498
Severe Combined Immunodeficiency 4 | 46
astrocytic glioma 4 | 2,241
ductal carcinoma in situ 4 | 1,745
gastric carcinoma 4 | 832
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
progressive supranuclear palsy 4 | 674
sonic hedgehog group medulloblastoma 4 | 1,482
Adult T-Cell Lymphoma/Leukemia 3 | 30
Anemia 3 | 252
Barrett's esophagus 3 | 183
Cardiomegaly 3 | 66
Cherubism 3 | 14
Chronic lymphoid leukemia, disease 3 | 10
Chronic obstructive pulmonary disease 3 | 146
Chronic phase chronic myeloid leukemia 3 | 45
Diffuse large B-cell lymphoma 3 | 41
Down syndrome 3 | 548
Lupus erythematosus 3 | 80
Obesity 3 | 616
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 3 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 3 | 47
X-linked agammaglobulinemia 3 | 7
acute myeloid leukemia 3 | 780
acute quadriplegic myopathy 3 | 1,157
breast carcinoma 3 | 1,614
chronic rhinosinusitis 3 | 512
dermatomyositis 3 | 933
group 3 medulloblastoma 3 | 2,254
medulloblastoma 3 | 1,524
posterior fossa group A ependymoma 3 | 1,511
tuberculosis and treatment for 6 months 3 | 686
Alzheimer's disease 2 | 644
Hypertension 2 | 287
Prostatic Neoplasms 2 | 471
Urticaria 2 | 53
Vasculitis 2 | 64
active Crohn's disease 2 | 918
ependymoma 2 | 2,514
fibroadenoma 2 | 557
mucosa-associated lymphoid tissue lymphoma 2 | 480
pancreatic carcinoma 2 | 567
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 79 | 17,995
Female tissues 79 | 18,647
Digestive Tract 78 | 18,473
Liver and Pancreas 78 | 18,136
Respiratory system 78 | 17,484
Skin and soft tissues 78 | 18,115
Urinary Tract 77 | 18,444
Cardiovascular System 76 | 17,958
Nervous System 75 | 18,561
Endocrine System 74 | 18,512
Male tissues 73 | 17,969

Target Family

Non-IDG 74 | 11,971
Enzyme 8 | 4,146
Kinase 8 | 634
Ion Channel 5 | 341

Reactome Pathway

Antigen activates B Cell Recep... 95 | 95
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Ig lambda-7 chain C region IGLC7 Tdark Non-IDG 228.7 0
Immunoglobulin lambda variable 1-44 IGLV1-44 Tdark Non-IDG 0.00000 0
Immunoglobulin heavy variable 1-2 IGHV1-2 Tdark Non-IDG 0.00000 0
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Immunoglobulin kappa variable 3-15 IGKV3-15 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 2-28 IGKV2-28 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 2D-30 IGKV2D-30 Tdark Non-IDG 0.00000 0