Development Level

Tdark 57 | 6,569
Tbio 17 | 11,178
Tchem 15 | 1,885
Tclin 6 | 612

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal embryo size 2 | 220
decreased body weight 2 | 161
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal maxilla morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydrometra 1 | 53
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased erythrocyte cell num... 1 | 39
increased heart left ventricle... 1 | 4
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
small epididymis 1 | 3
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

osteosarcoma 36 | 7,766
Carcinoma 26 | 11,192
lung cancer 25 | 4,607
interstitial cystitis 24 | 2,237
psoriasis 24 | 6,514
ovarian cancer 23 | 8,297
Cancer 20 | 2,388
ulcerative colitis 18 | 1,765
tuberculosis 17 | 1,963
medulloblastoma, large-cell 16 | 6,086
primary Sjogren syndrome 16 | 710
subependymal giant cell astrocytoma 15 | 2,230
glioblastoma 14 | 5,635
pancreatic cancer 13 | 2,322
cutaneous lupus erythematosus 12 | 1,016
periodontitis 12 | 280
Kidney cancer 11 | 2,548
Multiple myeloma 11 | 1,296
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,204
lung adenocarcinoma 11 | 2,627
lung carcinoma 11 | 2,755
non-small cell lung cancer 11 | 2,799
Autosomal recessive predisposition 10 | 1,407
cystic fibrosis 10 | 1,629
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,902
invasive ductal carcinoma 10 | 2,867
Breast cancer 9 | 3,469
Immunologic Deficiency Syndromes 9 | 110
Agammaglobulinemia 8 | 34
Increased susceptibility to bacterial infections 8 | 40
Pick disease 8 | 1,856
Prone to bacterial infection 8 | 40
Recurrent bacterial infection 8 | 40
adult high grade glioma 8 | 3,701
chronic lymphosyte leukemia 8 | 199
group 3 medulloblastoma 8 | 4,002
Arthritis 7 | 276
Astrocytoma, Pilocytic 7 | 3,006
Chronic otitis media 7 | 52
Conjunctivitis 7 | 51
Conjunctivitis, recurrent 7 | 35
Diarrhea 7 | 245
Rheumatoid arthritis 7 | 1,156
colon cancer 7 | 1,428
ear infection chronic 7 | 52
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,872
juvenile dermatomyositis 7 | 1,147
malignant mesothelioma 7 | 3,135
primary pancreatic ductal adenocarcinoma 7 | 1,071
Exanthema 6 | 42
Failure to gain weight 6 | 359
Fatigue 6 | 176
Fever 6 | 136
Paranasal Sinus Diseases 6 | 34
Pediatric failure to thrive 6 | 359
Sinusitis 6 | 63
atypical teratoid / rhabdoid tumor 6 | 4,971
diabetes mellitus 6 | 1,683
esophageal adenocarcinoma 6 | 696
oligodendroglioma 6 | 2,768
AGAMMAGLOBULINEMIA 1, AUTOSOMAL RECESSIVE 5 | 8
Agammaglobulinemia, non-Bruton type 5 | 8
Bronchiectasis 5 | 63
Coughing 5 | 23
Infantile onset 5 | 236
Infection of bone 5 | 19
Infectious disease of lung 5 | 29
Macroglobulinemia 5 | 17
Multiple pulmonary infections 5 | 29
Osteomyelitis 5 | 42
Recurrent otitis media 5 | 41
Recurrent pneumonia 5 | 29
Recurrent pulmonary infections 5 | 29
Recurrent respiratory infections 5 | 138
Recurrent skin infections 5 | 21
Waldenstrons macroglobulinemia 5 | 742
astrocytic glioma 5 | 2,530
cystic fibrosis and chronic rhinosinusitis 5 | 211
nasopharyngeal carcinoma 5 | 1,024
non-small cell lung carcinoma 5 | 302
pediatric high grade glioma 5 | 1,035
pituitary cancer 5 | 1,915
primitive neuroectodermal tumor 5 | 2,957
spina bifida 5 | 1,053
Allergic hypersensitivity disease 4 | 124
Amebiasis 4 | 21
Anemia 4 | 353
Chronic obstructive pulmonary disease 4 | 175
Hypertension 4 | 372
Lymphoma 4 | 75
Melanoma 4 | 689
Multiple Sclerosis 4 | 527
Neutrophil count decreased 4 | 46
Schizophrenia 4 | 1,136
Severe combined immunodeficiency 4 | 49
astrocytoma 4 | 1,113
ductal carcinoma in situ 4 | 1,686
gastric carcinoma 4 | 781
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,911
progressive supranuclear palsy 4 | 656

Tissue

Blood and immune system 33 | 16,909
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Cardiovascular System 32 | 15,192

Target Family

Non-IDG 75 | 12,091
Kinase 8 | 634
Enzyme 7 | 4,145
Ion Channel 5 | 344

Reactome Pathway

Antigen activates B Cell Recep... 95 | 95
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3D-20 IGKV3D-20 Tdark Non-IDG 0.00000 0
Inositol 1,4,5-trisphosphate receptor type 1 ITPR1 Tchem Ion Channel -2.75840 565.6 230
Immunoglobulin lambda variable 3-21 IGLV3-21 Tdark Non-IDG 0.00000 0
Inositol 1,4,5-trisphosphate receptor type 2 ITPR2 Tchem Ion Channel -1.91547 77.7 97
Inositol 1,4,5-trisphosphate receptor type 3 ITPR3 Tchem Ion Channel -2.51894 316.1 127
Immunoglobulin lambda variable 7-43 IGLV7-43 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 1-16 IGKV1-16 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 1D-39 IGKV1D-39 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733