Development Level

Tbio 6 | 11,651

IMPC Phenotype

abnormal skin morphology 1 | 50
abnormal tooth morphology 1 | 24

Disease

Carcinoma 6 | 11,493
Kidney cancer 6 | 2,613
malignant mesothelioma 5 | 3,232
Abnormal blistering of the skin 4 | 54
Anemia 4 | 365
Aplasia Cutis Congenita 4 | 14
Atrophic scar 4 | 18
Autosomal recessive predisposition 4 | 1,442
Blister of skin 4 | 54
Breast cancer 4 | 3,578
Congenital localized absence of skin 4 | 6
Congenital scar 4 | 13
Defective enamel matrix 4 | 35
Dental Enamel Hypoplasia 4 | 43
Dental caries 4 | 164
Dysplasia of tooth enamel 4 | 35
Dystrophia unguium 4 | 53
Epidermolysis bullosa 4 | 21
Esophageal Stenosis 4 | 15
Hemoglobin low 4 | 124
Milium Cyst 4 | 16
Nail dysplasia 4 | 52
Oral mucosal blistering 4 | 10
Prenatal onset 4 | 139
Rotting teeth 4 | 73
Scarring alopecia of scalp 4 | 13
Skin Erosion 4 | 12
Skin bulla 4 | 54
Thin dental enamel 4 | 35
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung carcinoma 4 | 2,843
ANONYCHIA 3 | 20
Abnormal pigmentation 3 | 25
Adult junctional epidermolysis bullosa (disorder) 3 | 5
Death in early childhood 3 | 82
Death in infancy 3 | 82
Dehydration 3 | 40
Dyspnea 3 | 76
Epidermolysis Bullosa, Junctional 3 | 4
Epidermolysis Bullosa, Junctional, Non-Herlitz Type 3 | 5
Failure to gain weight 3 | 365
Feeding difficulties 3 | 127
Flexion contracture of proximal interphalangeal joint 3 | 75
Fragile nails 3 | 16
Herlitz Disease 3 | 3
Hoarseness 3 | 31
Hypodontia 3 | 81
Junctional epidermolysis bullosa 3 | 7
Junctional split 3 | 6
Laryngismus 3 | 3
Laryngostenosis 3 | 10
Melanoma 3 | 711
Palmar hyperhidrosis 3 | 5
Paronychia Inflammation 3 | 9
Pediatric failure to thrive 3 | 365
Plantar hyperkeratosis 3 | 7
Pyloric Stenosis 3 | 47
Sparse body hair 3 | 32
Wounds and Injuries 3 | 18
breast carcinoma 3 | 1,638
esophageal adenocarcinoma 3 | 737
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung cancer 3 | 4,740
non-small cell lung cancer 3 | 2,890
ovarian cancer 3 | 8,520
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Adult junctional epidermolysis bullosa 2 | 3
Age related macular degeneration 1 2 | 4
Amelogenesis imperfecta 2 | 29
Barrett's esophagus 2 | 182
Cataract 2 | 297
Generalized junctional epidermolysis bullosa, non-Herlitz type 2 | 3
Skin cancer 2 | 469
active ulcerative colitis 2 | 764
invasive ductal carcinoma 2 | 2,951
junctional epidermolysis bullosa Herlitz type 2 | 2
lung adenocarcinoma 2 | 2,716
medulloblastoma, large-cell 2 | 6,241
non-small cell lung carcinoma 2 | 317
psoriasis 2 | 6,694
Abnormality of the fingernails 1 | 51
Amelogenesis imperfecta local hypoplastic form 1 | 1
Atrial heart septal defect 1 | 18
Autosomal recessive non-syndromic intellectual disability 1 | 7
Conjunctivitis 1 | 53
Deglutition Disorders 1 | 132
Delayed Puberty 1 | 97
Dilated cardiomyopathy 1D 1 | 3
Ellis-Van Creveld syndrome 1 | 19
Epidermolysis bullosa inversa dystrophica 1 | 1
Fragile skin 1 | 18
Generalized microdontia 1 | 1
Malignant Squamous Cell Neoplasm 1 | 17
Neurotic excoriation 1 | 2
Skin Ulcer 1 | 48
chronic kidney disease 1 | 90
hypopigmented skin patch 1 | 59

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678
Respiratory system 5 | 16,393

Target Family

Non-IDG 6 | 12,091

Reactome Pathway

Anchoring fibril formation 6 | 6
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Laminin subunit gamma-2 LAMC2 Tbio Non-IDG -2.09168 112.5 175
Laminin subunit beta-3 LAMB3 Tbio Non-IDG -2.07156 116.4 170
Tolloid-like protein 2 TLL2 Tbio Non-IDG -1.00652 6.10 35
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.44490 24.3 83
Collagen alpha-1(VII) chain COL7A1 Tbio Non-IDG -2.58130 371.7 95
Laminin subunit alpha-3 LAMA3 Tbio Non-IDG -2.53686 344.3 110