Development Level

Tbio 76 | 11,445
Tchem 10 | 1,598
Tdark 6 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 4 | 278
decreased circulating choleste... 3 | 93
increased fasted circulating g... 3 | 76
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal tail morphology 2 | 25
cataract 2 | 92
decreased heart left ventricle... 2 | 28
embryonic growth retardation 2 | 106
increased circulating HDL chol... 2 | 80
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal motor learning 1 | 3
abnormal placenta morphology 1 | 5
abnormal placenta size 1 | 20
abnormal placenta vasculature 1 | 2
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal testis morphology 1 | 43
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
long tibia 1 | 25
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small testis 1 | 58
syndactyly 1 | 23

Disease

Carcinoma 61 | 11,493
medulloblastoma, large-cell 59 | 6,241
ovarian cancer 59 | 8,520
glioblastoma 54 | 5,792
group 3 medulloblastoma 54 | 4,104
atypical teratoid / rhabdoid tumor 52 | 5,112
lung cancer 50 | 4,740
psoriasis 45 | 6,694
primitive neuroectodermal tumor 43 | 3,035
Breast cancer 42 | 3,578
osteosarcoma 42 | 7,950
non-small cell lung cancer 38 | 2,890
adrenocortical carcinoma 36 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
adult high grade glioma 35 | 3,801
ependymoma 32 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
malignant mesothelioma 31 | 3,232
invasive ductal carcinoma 30 | 2,951
lung adenocarcinoma 26 | 2,716
breast carcinoma 22 | 1,638
ductal carcinoma in situ 22 | 1,745
colon cancer 21 | 1,478
Endometriosis 20 | 540
pancreatic cancer 20 | 2,398
Atopic dermatitis 18 | 952
Kidney cancer 18 | 2,613
nasopharyngeal carcinoma 18 | 1,058
oligodendroglioma 17 | 2,850
Cancer 16 | 2,499
Multiple myeloma 13 | 1,332
Waldenstrons macroglobulinemia 12 | 765
astrocytic glioma 12 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Pick disease 11 | 1,894
dermatomyositis 11 | 966
Astrocytoma, Pilocytic 10 | 3,081
Intellectual disability 10 | 1,016
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
pediatric high grade glioma 10 | 1,064
subependymal giant cell astrocytoma 10 | 2,287
ulcerative colitis 9 | 1,819
Cognitive delay 8 | 608
Dull intelligence 8 | 645
Global developmental delay 8 | 608
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Poor school performance 8 | 645
Small head 8 | 374
acute quadriplegic myopathy 8 | 1,158
tuberculosis 8 | 2,010
Epilepsy 7 | 792
Microcephaly 7 | 166
Seizures 7 | 596
active Crohn's disease 7 | 922
interstitial cystitis 7 | 2,312
pituitary cancer 7 | 1,972
primary Sjogren syndrome 7 | 735
Lissencephaly 6 | 69
Rheumatoid arthritis 6 | 1,191
acute myeloid leukemia 6 | 783
gastric carcinoma 6 | 807
hereditary spastic paraplegia 6 | 318
juvenile dermatomyositis 6 | 1,187
Autosomal recessive predisposition 5 | 1,442
Cerebellar Hypoplasia 5 | 61
Dilated ventricles (finding) 5 | 121
Downward slant of palpebral fissure 5 | 158
Hypoplastic mandible condyle 5 | 275
Lymphoid leukemia 5 | 160
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Orbital separation excessive 5 | 244
Schizophrenia 5 | 1,160
Short stature 5 | 531
astrocytoma 5 | 1,146
posterior fossa group A ependymoma 5 | 468
tuberculosis and treatment for 6 months 5 | 409
Congenital Epicanthus 4 | 177
Glaucoma 4 | 239
Hydrocephalus 4 | 152
Pachygyria 4 | 41
Polyhydramnios 4 | 108
Stomach Neoplasms 4 | 300
cystic fibrosis and chronic rhinosinusitis 4 | 214
group 4 medulloblastoma 4 | 1,855
inflammatory breast cancer 4 | 286
lung carcinoma 4 | 2,843
Abnormally small eyeball 3 | 97
Anteverted nostril 3 | 191
Bipolar Disorder 3 | 666
Decreased size of eyeball 3 | 97
Endometrial cancer 3 | 311
Lens Opacities 3 | 231
Leukemia 3 | 104
aldosterone-producing adenoma 3 | 665
hepatocellular carcinoma 3 | 547
medulloblastoma 3 | 720

Tissue

Endocrine System 92 | 18,159
Blood and immune system 91 | 16,909
Digestive Tract 91 | 17,369
Female tissues 91 | 17,400
Liver and Pancreas 91 | 16,750
Male tissues 91 | 17,142
Nervous System 91 | 16,725
Respiratory system 91 | 16,393
Skin and soft tissues 91 | 17,230
Urinary Tract 91 | 16,678
Cardiovascular System 88 | 15,192

Target Family

Non-IDG 73 | 12,091
Enzyme 14 | 4,145
Kinase 5 | 634

Reactome Pathway

Amplification of signal from ... 92 | 92
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
Centromere protein K CENPK Tbio Non-IDG -1.21832 16.6 130
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Kinesin-like protein KIF2C KIF2C Tbio Non-IDG -2.12404 136.3 256
Spindle and kinetochore-associated protein 2 SKA2 Tbio Non-IDG -1.23206 10.2 108
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169
Centromere protein F CENPF Tbio Non-IDG -2.02939 109.1 186
Nuclear pore complex protein Nup85 NUP85 Tbio Non-IDG -1.23703 17.9 139
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221