Development Level

Tbio 24 | 11,445
Tchem 8 | 1,598

IMPC Phenotype

abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal kidney morphology 1 | 65
abnormal optic disc morphology 1 | 10
abnormal spleen morphology 1 | 55
abnormal urinary bladder morph... 1 | 11
abnormal vitreous body morphol... 1 | 10
cystolithiasis 1 | 3
decreased caudal vertebrae num... 1 | 53
decreased total body fat amoun... 1 | 207
enlarged epididymis 1 | 31
enlarged kidney 1 | 14
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased circulating glucose ... 1 | 24
increased lean body mass 1 | 172
polycystic kidney 1 | 15
preweaning lethality, incomple... 1 | 499
small kidney 1 | 16

Disease

Carcinoma 24 | 11,493
osteosarcoma 18 | 7,950
ovarian cancer 12 | 8,520
atypical teratoid / rhabdoid tumor 11 | 5,112
lung cancer 11 | 4,740
medulloblastoma, large-cell 11 | 6,241
psoriasis 10 | 6,694
Breast cancer 9 | 3,578
Lysinuric protein intolerance 9 | 15
ependymoma 9 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
malignant mesothelioma 9 | 3,232
pancreatic cancer 9 | 2,398
Cystinuria 8 | 18
colon cancer 8 | 1,478
cystic fibrosis 8 | 1,696
glioblastoma 8 | 5,792
invasive ductal carcinoma 8 | 2,951
lung carcinoma 8 | 2,843
non-small cell lung cancer 8 | 2,890
active Crohn's disease 7 | 922
active ulcerative colitis 7 | 764
group 3 medulloblastoma 7 | 4,104
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
tuberculosis 7 | 2,010
ulcerative colitis 7 | 1,819
Cancer 6 | 2,499
Hartnup disease 6 | 13
ductal carcinoma in situ 6 | 1,745
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
Astrocytoma, Pilocytic 5 | 3,081
Schizophrenia 5 | 1,160
group 4 medulloblastoma 5 | 1,855
lung adenocarcinoma 5 | 2,716
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
Autosomal recessive predisposition 4 | 1,442
Iminoglycinuria 4 | 4
atypical teratoid/rhabdoid tumor 4 | 357
breast carcinoma 4 | 1,638
pediatric high grade glioma 4 | 1,064
Atopic dermatitis 3 | 952
Barrett's esophagus 3 | 182
Duchenne muscular dystrophy 3 | 601
Epilepsy 3 | 792
HYPERGLYCINURIA (disorder) 3 | 12
Hyperglycinuria 3 | 3
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
Pick disease 3 | 1,894
Polycystic ovary syndrome 3 | 360
Rheumatoid arthritis 3 | 1,191
acute quadriplegic myopathy 3 | 1,158
adult high grade glioma 3 | 3,801
diabetes mellitus 3 | 1,728
nephrosclerosis 3 | 333
Amyotrophic lateral sclerosis 2 | 451
COPD 2 | 118
Cognitive delay 2 | 608
Crohn's disease 2 | 321
Dull intelligence 2 | 645
Endometriosis 2 | 540
Failure to gain weight 2 | 365
Highly variable severity 2 | 157
Kidney Failure 2 | 111
Kidney cancer 2 | 2,613
Liver Cirrhosis, Experimental 2 | 769
Lung Neoplasms 2 | 232
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Nephrolithiasis 2 | 56
Orotic aciduria 2 | 18
Pediatric failure to thrive 2 | 365
Pellagra 2 | 26
Placental insufficiency 2 | 18
Poor school performance 2 | 645
Recurrent urinary tract infection 2 | 24
Renal Insufficiency 2 | 90
Renal failure in adulthood 2 | 76
Variable expressivity 2 | 157
X-linked cerebral adrenoleukodystrophy 2 | 116
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
astrocytic glioma 2 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
facioscapulohumeral dystrophy 2 | 288
gastric carcinoma 2 | 807
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
juvenile dermatomyositis 2 | 1,187
nasopharyngeal carcinoma 2 | 1,058
non diabetic and post-ischemic heart failure 2 | 200
posterior fossa group B ependymoma 2 | 416
primary Sjogren syndrome 2 | 735
primary pancreatic ductal adenocarcinoma 2 | 1,109
spina bifida 2 | 1,074
uncontrolled asthma 2 | 56

Tissue

Urinary Tract 32 | 16,678
Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Skin and soft tissues 31 | 17,230
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Respiratory system 29 | 16,393
Cardiovascular System 25 | 15,192

Target Family

Transporter 32 | 473

Reactome Pathway

Amino acid transport across th... 32 | 32
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cationic amino acid transporter 3 SLC7A3 Tbio Transporter -2.20835 146.6 38
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter -1.90516 156.1 254
Proton-coupled amino acid transporter 2 SLC36A2 Tchem Transporter -1.78507 61.5 88
Sodium-coupled neutral amino acid transporter 5 SLC38A5 Tbio Transporter -3.03889 1061.8 77
Sodium-coupled neutral amino acid transporter 3 SLC38A3 Tbio Transporter 0.00000 59
Cationic amino acid transporter 2 SLC7A2 Tbio Transporter -1.55868 37.6 57
Sodium-coupled neutral amino acid transporter 2 SLC38A2 Tbio Transporter -1.98482 96.5 91
Sodium-dependent neutral amino acid transporter B(0)AT1 SLC6A19 Tchem Transporter -1.89653 74.4 32
Sodium- and chloride-dependent betaine transporter SLC6A12 Tchem Transporter -2.34582 212.0 104
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 Tchem Transporter -1.42715 25.8 76