Development Level

Tbio 22 | 11,445
Tchem 7 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

abnormal behavior 3 | 298
hyperactivity 3 | 148
preweaning lethality, complete... 3 | 979
decreased leukocyte cell numbe... 2 | 73
increased bone mineral content 2 | 108
increased heart weight 2 | 62
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal sleep behavior 1 | 70
abnormal tail movements 1 | 12
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased anxiety-related resp... 1 | 2
increased circulating bilirubi... 1 | 16
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
limb grasping 1 | 41
male infertility 1 | 123
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small adrenal glands 1 | 16
thrombocytopenia 1 | 56

Disease

Carcinoma 21 | 11,493
medulloblastoma, large-cell 19 | 6,241
psoriasis 19 | 6,694
ovarian cancer 18 | 8,520
osteosarcoma 17 | 7,950
atypical teratoid / rhabdoid tumor 16 | 5,112
glioblastoma 16 | 5,792
adult high grade glioma 14 | 3,801
ependymoma 14 | 4,679
group 3 medulloblastoma 14 | 4,104
Astrocytoma, Pilocytic 13 | 3,081
primitive neuroectodermal tumor 13 | 3,035
lung cancer 12 | 4,740
non-small cell lung cancer 11 | 2,890
Autosomal recessive predisposition 9 | 1,442
astrocytic glioma 9 | 2,597
Breast cancer 8 | 3,578
Liver Cirrhosis, Experimental 8 | 769
Pick disease 8 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
invasive ductal carcinoma 8 | 2,951
lung carcinoma 8 | 2,843
oligodendroglioma 8 | 2,850
subependymal giant cell astrocytoma 8 | 2,287
Cancer 7 | 2,499
Down syndrome 7 | 499
Intellectual disability 7 | 1,016
ductal carcinoma in situ 7 | 1,745
lung adenocarcinoma 7 | 2,716
Cognitive delay 6 | 608
Epilepsy 6 | 792
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Schizophrenia 6 | 1,160
Seizures 6 | 596
adrenocortical carcinoma 6 | 1,428
interstitial cystitis 6 | 2,312
malignant mesothelioma 6 | 3,232
pancreatic cancer 6 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Dull intelligence 5 | 645
Fetal Growth Retardation 5 | 189
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Multiple myeloma 5 | 1,332
Poor school performance 5 | 645
Small head 5 | 374
Atopic dermatitis 4 | 952
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Liver neoplasms 4 | 130
Microcephaly 4 | 166
Polycystic ovary syndrome 4 | 360
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
aldosterone-producing adenoma 4 | 665
astrocytoma 4 | 1,146
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
nasopharyngeal carcinoma 4 | 1,058
pituitary cancer 4 | 1,972
progressive supranuclear palsy 4 | 676
Hyperreflexia 3 | 209
Hypoplasia of corpus callosum 3 | 90
Hypoplastic mandible condyle 3 | 275
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Muscle hypotonia 3 | 571
Obesity 3 | 678
Orbital separation excessive 3 | 244
Prostatic Neoplasms 3 | 495
Serine deficiency 3 | 9
Sloping forehead 3 | 46
breast carcinoma 3 | 1,638
chronic rhinosinusitis 3 | 512
cystic fibrosis 3 | 1,696
fibroadenoma 3 | 559
gastric cancer 3 | 459
juvenile dermatomyositis 3 | 1,187
medulloblastoma 3 | 720
ulcerative colitis 3 | 1,819
Acquired scoliosis 2 | 281
Curvature of spine 2 | 282
Cutis Laxa 2 | 39
Depressive disorder 2 | 409
Failure to gain weight 2 | 365
Mental Depression 2 | 333
Pediatric failure to thrive 2 | 365
Prostate cancer 2 | 175
acute quadriplegic myopathy 2 | 1,158
hepatocellular carcinoma 2 | 547
pancreatic carcinoma 2 | 562
primary pancreatic ductal adenocarcinoma 2 | 1,109
tuberculosis and treatment for 3 months 2 | 179

Tissue

Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Nervous System 31 | 16,725
Blood and immune system 30 | 16,909
Cardiovascular System 30 | 15,192
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678

Target Family

Enzyme 27 | 4,145
Non-IDG 5 | 12,091

Reactome Pathway

Amino acid synthesis and inter... 32 | 32
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-citrylglutamate synthase B RIMKLB Tdark Enzyme -0.33579 2.63 48
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293
N-acetylated-alpha-linked acidic dipeptidase 2 NAALAD2 Tchem Enzyme -1.51589 30.6 39
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Putative N-acetylated-alpha-linked acidic dipeptidase FOLH1B Tbio Enzyme -3.08831 2219.0 0
Glutaminase liver isoform, mitochondrial GLS2 Tbio Enzyme -3.14287 1343.1 167
Serine incorporator 4 SERINC4 Tdark Non-IDG 0.00000 33
Serine incorporator 3 SERINC3 Tbio Non-IDG -2.44903 264.3 131
Glutaminase kidney isoform, mitochondrial GLS Tchem Enzyme -2.92171 795.3 268
Alanine aminotransferase 1 GPT Tbio Enzyme -2.47451 285.2 217