Development Level

Tbio 46 | 11,651
Tchem 5 | 1,388
Tdark 1 | 6,593

IMPC Phenotype

increased body length 2 | 32
preweaning lethality, incomple... 2 | 499
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal kidney morphology 1 | 65
abnormal optic disc morphology 1 | 10
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal urinary bladder morph... 1 | 11
abnormal vitreous body morphol... 1 | 10
cystolithiasis 1 | 3
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased exploration in new e... 1 | 11
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
decreased urine creatinine lev... 1 | 3
enlarged epididymis 1 | 31
enlarged kidney 1 | 14
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
improved glucose tolerance 1 | 79
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased lean body mass 1 | 172
polycystic kidney 1 | 15
preweaning lethality, complete... 1 | 979
prolonged QRS complex duration 1 | 8
small kidney 1 | 16

Disease

Carcinoma 41 | 11,493
osteosarcoma 24 | 7,950
atypical teratoid / rhabdoid tumor 21 | 5,112
medulloblastoma, large-cell 20 | 6,241
ovarian cancer 20 | 8,520
ependymoma 18 | 4,679
glioblastoma 18 | 5,792
psoriasis 18 | 6,694
lung carcinoma 15 | 2,843
Astrocytoma, Pilocytic 14 | 3,081
group 3 medulloblastoma 14 | 4,104
lung cancer 14 | 4,740
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
oligodendroglioma 13 | 2,850
Schizophrenia 12 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
invasive ductal carcinoma 12 | 2,951
malignant mesothelioma 12 | 3,232
pancreatic cancer 12 | 2,398
adult high grade glioma 11 | 3,801
primitive neuroectodermal tumor 11 | 3,035
Breast cancer 10 | 3,578
Epilepsy 10 | 792
cystic fibrosis 10 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 10 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
pituitary cancer 10 | 1,972
tuberculosis 10 | 2,010
Cancer 9 | 2,499
Lysinuric protein intolerance 9 | 15
interstitial cystitis 9 | 2,312
subependymal giant cell astrocytoma 9 | 2,287
Cystinuria 8 | 18
active ulcerative colitis 8 | 764
colon cancer 8 | 1,478
ductal carcinoma in situ 8 | 1,745
Bipolar Disorder 7 | 666
Pick disease 7 | 1,894
active Crohn's disease 7 | 922
astrocytic glioma 7 | 2,597
ulcerative colitis 7 | 1,819
Autosomal recessive predisposition 6 | 1,442
Hartnup disease 6 | 13
group 4 medulloblastoma 6 | 1,855
lung adenocarcinoma 6 | 2,716
pediatric high grade glioma 6 | 1,064
Amyotrophic lateral sclerosis 5 | 451
Atopic dermatitis 5 | 952
Kidney cancer 5 | 2,613
Muscle hypotonia 5 | 571
Rheumatoid arthritis 5 | 1,191
Seizures 5 | 596
atypical teratoid/rhabdoid tumor 5 | 357
breast carcinoma 5 | 1,638
cutaneous lupus erythematosus 5 | 1,057
primary pancreatic ductal adenocarcinoma 5 | 1,109
Cognitive delay 4 | 608
Dicarboxylic aminoaciduria 4 | 4
Dull intelligence 4 | 645
Global developmental delay 4 | 608
Iminoglycinuria 4 | 4
Intellectual disability 4 | 1,016
Liver Cirrhosis, Experimental 4 | 769
Low intelligence 4 | 645
Melanoma 4 | 711
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Parkinson's disease 4 | 392
Poor school performance 4 | 645
astrocytoma 4 | 1,146
gastric carcinoma 4 | 807
nephrosclerosis 4 | 333
non primary Sjogren syndrome sicca 4 | 891
posterior fossa group B ependymoma 4 | 416
Alzheimer's disease 3 | 658
Barrett's esophagus 3 | 182
Duchenne muscular dystrophy 3 | 601
Endometriosis 3 | 540
Failure to gain weight 3 | 365
Growth delay 3 | 114
Growth failure 3 | 114
Growth retardation 3 | 115
Major Depressive Disorder 3 | 301
Multiple myeloma 3 | 1,332
Pediatric failure to thrive 3 | 365
Polycystic ovary syndrome 3 | 360
Poor growth 3 | 114
Systemic lupus erythematosus 3 | 194
Toxic encephalopathy 3 | 141
Unipolar Depression 3 | 250
Very poor growth 3 | 114
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
diabetes mellitus 3 | 1,728
facioscapulohumeral dystrophy 3 | 288
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
spina bifida 3 | 1,074

Tissue

Endocrine System 51 | 18,159
Nervous System 50 | 16,725
Urinary Tract 50 | 16,678
Digestive Tract 49 | 17,369
Blood and immune system 48 | 16,909
Female tissues 48 | 17,400
Male tissues 48 | 17,142
Liver and Pancreas 47 | 16,750
Skin and soft tissues 47 | 17,230
Respiratory system 46 | 16,393
Cardiovascular System 39 | 15,192

Target Family

Transporter 52 | 473

Reactome Pathway

Amino acid and oligopeptide SL... 52 | 52
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sialin SLC17A5 Tbio Transporter -2.93541 845.6 63
Proton-coupled amino acid transporter 4 SLC36A4 Tbio Transporter -1.46987 30.6 45
High affinity cationic amino acid transporter 1 SLC7A1 Tbio Transporter -2.71485 501.4 143
Vesicular glutamate transporter 3 SLC17A8 Tbio Transporter -2.00898 110.3 57
Y+L amino acid transporter 1 SLC7A7 Tbio Transporter -1.73334 56.0 46
Large neutral amino acids transporter small subunit 2 SLC7A8 Tbio Transporter -1.20076 18.8 126
Vesicular inhibitory amino acid transporter SLC32A1 Tbio Transporter -2.58494 352.6 151
4F2 cell-surface antigen heavy chain SLC3A2 Tbio Transporter -2.82471 653.6 604
Sodium-dependent neutral amino acid transporter B(0)AT2 SLC6A15 Tbio Transporter -1.77493 56.8 98
Sodium/iodide cotransporter SLC5A5 Tbio Transporter -3.03414 1016.4 360