Development Level

Tbio 8 | 11,445
Tclin 5 | 613
Tchem 4 | 1,598

IMPC Phenotype

abnormal sleep behavior 1 | 70
decreased bone mineral density 1 | 126
decreased exploration in new e... 1 | 11
decreased prepulse inhibition 1 | 82
decreased urine creatinine lev... 1 | 3
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased circulating sodium l... 1 | 71
prolonged QRS complex duration 1 | 8

Disease

Carcinoma 11 | 11,493
psoriasis 10 | 6,694
Bipolar Disorder 9 | 666
Hypothyroidism 9 | 122
Autosomal recessive predisposition 7 | 1,442
Constipation 6 | 181
Congenital hypothyroidism 5 | 26
Depressive disorder 5 | 409
Dyschezia 5 | 135
Goiter 5 | 38
Hypertension 5 | 396
Hyperthyroidism 5 | 53
Major Depressive Disorder 5 | 301
Mental Depression 5 | 333
Schizophrenia 5 | 1,160
Unipolar Depression 5 | 250
lung cancer 5 | 4,740
lung carcinoma 5 | 2,843
Abdomen distended 4 | 43
Attention deficit hyperactivity disorder 4 | 278
Coarse facial features 4 | 108
Cognitive delay 4 | 608
Fatigue 4 | 182
Global developmental delay 4 | 608
Icterus 4 | 82
Intellectual disability 4 | 1,016
Large bregma sutures 4 | 46
Large fontanelle 4 | 46
Large, late-closing fontanelle 4 | 46
Macroglossia 4 | 65
Mental and motor retardation 4 | 608
Mood Disorders 4 | 184
Muscle hypotonia 4 | 571
Thickened facial skin with coarse facial features 4 | 108
Thyroid Dyshormonogenesis 1 4 | 6
Umbilical hernia 4 | 93
Wide bregma sutures 4 | 46
adrenocortical carcinoma 4 | 1,428
aldosterone-producing adenoma 4 | 665
lung adenocarcinoma 4 | 2,716
osteosarcoma 4 | 7,950
Alcoholic Intoxication, Chronic 3 | 289
Blepharoptosis 3 | 231
Dull intelligence 3 | 645
Hypersomnia 3 | 8
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Parkinson's disease 3 | 392
Pheochromocytoma 3 | 24
Poor school performance 3 | 645
Short stature 3 | 531
Sudden infant death syndrome 3 | 32
Thyrotoxicosis 3 | 38
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
medulloblastoma, large-cell 3 | 6,241
Abnormality of metabolism/homeostasis 2 | 134
Alcohol dependence 2 | 107
Atherosclerosis 2 | 291
Autism Spectrum Disorders 2 | 75
Autism spectrum disorder 2 | 101
Autistic Disorder 2 | 364
Axial hypotonia 2 | 46
Breast Neoplasms 2 | 445
Carcinoma, Hepatocellular 2 | 228
Diarrhea 2 | 253
Dystonia 2 | 164
Endometriosis 2 | 540
Infantile onset 2 | 238
Kidney Neoplasms 2 | 37
Kidney disease 2 | 430
Liver carcinoma 2 | 240
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Multiple system atrophy 2 | 29
Nerve Degeneration 2 | 121
Neuroblastoma 2 | 80
Parkinsonian Disorders 2 | 56
Pendred Syndrome 2 | 22
Psychotic Disorders 2 | 151
Ptosis 2 | 48
Sleep disturbances 2 | 37
Thyroid cancer 2 | 36
adrenocortical adenoma 2 | 131
adult high grade glioma 2 | 3,801
colon cancer 2 | 1,478
esophageal adenocarcinoma 2 | 737
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
ulcerative colitis 2 | 1,819
uncontrolled asthma 2 | 56

Tissue

Endocrine System 17 | 18,159
Nervous System 17 | 16,725
Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Skin and soft tissues 16 | 17,230
Male tissues 15 | 17,142
Respiratory system 15 | 16,393
Urinary Tract 15 | 16,678
Cardiovascular System 11 | 15,192

Target Family

Enzyme 14 | 4,145
Non-IDG 2 | 12,091
Transporter 1 | 473

Reactome Pathway

Amine-derived hormones 17 | 17
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycoprotein hormones alpha chain CGA Tbio Non-IDG -2.62079 405.6 915
Type I iodothyronine deiodinase DIO1 Tclin Enzyme -2.19858 153.3 82
Phenylethanolamine N-methyltransferase PNMT Tchem Enzyme -2.90323 857.6 277
Aromatic-L-amino-acid decarboxylase DDC Tclin Enzyme -2.78263 593.3 412
Thyroxine 5-deiodinase DIO3 Tbio Enzyme -2.21985 98.0 199
Acetylserotonin O-methyltransferase ASMT Tbio Enzyme -2.40166 255.0 111
Type II iodothyronine deiodinase DIO2 Tbio Enzyme -2.60036 368.6 134
Thyroid peroxidase TPO Tclin Enzyme -2.83776 580.4 368
Dual oxidase 1 DUOX1 Tbio Enzyme -2.50131 279.5 85
Dual oxidase 2 DUOX2 Tchem Enzyme -2.45061 251.8 126