Development Level

Tclin 29 | 602
Tchem 7 | 1,890
Tbio 5 | 10,625
Tdark 2 | 7,003

Collection

GPCR: IDG Consortium (Targets) 7 | 128
GPCR: IDG Consortium (Complete/Control) 1 | 24

IMPC Phenotype

abnormal behavioral response t... 2 | 52
cardiovascular system phenotyp... 1 | 35
decreased anxiety-related resp... 1 | 12
decreased fasted circulating g... 1 | 49
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
improved glucose tolerance 1 | 56
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
short tail 1 | 4

Disease

Schizophrenia 24 | 503
Parkinson's disease 21 | 364
psoriasis 20 | 6,685
Migraine 15 | 79
Attention deficit hyperactivity disorder 14 | 156
Nasal congestion 14 | 24
Nasal discharge 13 | 26
Asthma 11 | 349
Major Depressive Disorder 11 | 106
medulloblastoma, large-cell 11 | 6,234
osteosarcoma 11 | 7,933
Alcohol dependence 10 | 107
Allergic rhinitis 10 | 92
Bipolar Disorder 10 | 266
ovarian cancer 10 | 8,491
Autistic Disorder 9 | 320
Bronchitis 9 | 44
Common cold 9 | 63
Hypertensive disorder 9 | 58
Open-angle glaucoma 9 | 26
Orthostatic hypotension 9 | 9
Pulmonary emphysema 9 | 34
Substance abuse 9 | 55
diabetes mellitus 9 | 1,663
glioblastoma 9 | 5,572
Acute exacerbation of asthma 8 | 14
Allergic conjunctivitis 8 | 25
Asthma management 8 | 20
Bronchiectasis 8 | 29
General anesthesia 8 | 53
Low blood pressure 8 | 9
Obesity 8 | 616
Sneezing 8 | 11
Vasomotor rhinitis 8 | 15
oligodendroglioma 8 | 2,849
pilocytic astrocytoma 8 | 3,086
primitive neuroectodermal tumor 8 | 3,031
Administration of Local Anesthetic Nerve Block 7 | 14
Allergic Reactions 7 | 7
Alzheimer's disease 7 | 644
Cocaine-Related Disorders 7 | 88
Dyspnea 7 | 8
Epilepsy 7 | 346
Exacerbation of asthma 7 | 11
Gilles de la Tourette syndrome 7 | 47
Hypotension 7 | 53
Local anesthesia, by infiltration 7 | 14
Red eye 7 | 7
Seizures 7 | 95
Wheezing 7 | 7
anaphylaxis 7 | 11
ependymoma 7 | 2,514
malignant mesothelioma 7 | 3,163
pediatric high grade glioma 7 | 2,712
Amphetamine-Related Disorders 6 | 74
Cerebral ischemia 6 | 12
Cerebrovascular disease 6 | 231
Chronic obstructive lung disease 6 | 6
Cough 6 | 21
Dermal Necrosis 6 | 6
Diagnostic Test for Pheochromocytoma 6 | 6
Dilated pupil 6 | 6
Fever 6 | 34
Gastric ulcer 6 | 34
Hypertension Secondary to Pheochromocytoma 6 | 6
Hypertensive Emergencies 6 | 10
Influenza-like symptoms 6 | 17
Memory Disorders 6 | 36
Ocular hypertension 6 | 27
Parkinsonism 6 | 19
Paroxysmal hypertension 6 | 6
Peptic ulcer 6 | 22
Peripheral vascular disease 6 | 90
Pheochromocytoma 6 | 22
Prevention of Hypertension in Pheochromocytoma 6 | 6
Seasonal allergic rhinitis 6 | 10
Sinus headache 6 | 17
atypical teratoid / rhabdoid tumor 6 | 4,369
invasive ductal carcinoma 6 | 2,950
obsessive-compulsive disorder 6 | 34
Acromegaly 5 | 40
Amnestic disorder 5 | 37
Cluster headache syndrome 5 | 8
Depressive disorder 5 | 48
Gastrointestinal Radiography Adjunct 5 | 11
Headache disorder 5 | 20
Hyperactive behavior 5 | 31
Hyperprolactinemia 5 | 22
Hypertension 5 | 293
Hypertensive disease 5 | 193
Irritable bowel syndrome 5 | 59
Itching of skin 5 | 19
Migraine Prevention 5 | 22
Personality disorder 5 | 25
Rhinitis 5 | 46
Spasticity 5 | 26
Substance Withdrawal Syndrome 5 | 55
astrocytoma 5 | 1,493
lung cancer 5 | 4,473
medulloblastoma 5 | 1,524

Tissue

Nervous System 41 | 18,560
Female tissues 40 | 18,646
Urinary Tract 39 | 18,443
Digestive Tract 38 | 18,472
Endocrine System 37 | 18,511
Skin and soft tissues 36 | 18,114
Cardiovascular System 35 | 17,957
Liver and Pancreas 35 | 18,135
Male tissues 35 | 17,968
Respiratory system 33 | 17,483
Blood and immune system 32 | 17,994

Target Family

GPCR 43 | 408

Reactome Pathway

Amine ligand-binding receptors 43 | 43
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histamine H2 receptor HRH2 Tclin GPCR -3.21045 1579.7 225
D(2) dopamine receptor DRD2 Tclin GPCR -3.26127 1775.2 248
Alpha-1D adrenergic receptor ADRA1D Tclin GPCR -2.25094 175.2 111
Muscarinic acetylcholine receptor M2 CHRM2 Tclin GPCR -2.69239 489.7 349
Muscarinic acetylcholine receptor M4 CHRM4 Tclin GPCR -1.88768 75.0 128
Histamine H4 receptor HRH4 Tchem GPCR -2.38448 254.0 165
D(3) dopamine receptor DRD3 Tclin GPCR -2.49894 303.4 169
Alpha-1B adrenergic receptor ADRA1B Tclin GPCR -2.30332 198.4 327
Histamine H1 receptor HRH1 Tclin GPCR -3.01939 1011.4 345
Alpha-1A adrenergic receptor ADRA1A Tclin GPCR -2.17940 150.4 223