Development Level

Tclin 28 | 612
Tchem 7 | 1,388
Tbio 5 | 11,651
Tdark 1 | 6,593

Collection

GPCR: IDG Consortium (Targets) 6 | 126
RFA-RM-18-021 4 | 328
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

abnormal behavior 2 | 298
abnormal behavioral response t... 2 | 66
decreased total body fat amoun... 2 | 207
hyperactivity 2 | 148
increased circulating sodium l... 2 | 71
abnormal tail length 1 | 3
cardiovascular system phenotyp... 1 | 36
decreased anxiety-related resp... 1 | 12
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased circulating chloride... 1 | 41
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 30 | 11,493
Schizophrenia 29 | 1,160
Parkinson's disease 20 | 392
psoriasis 19 | 6,694
Bipolar Disorder 18 | 666
Depressive disorder 18 | 409
Mood Disorders 18 | 184
Major Depressive Disorder 15 | 301
Migraine 15 | 83
Attention deficit hyperactivity disorder 13 | 278
Mental Depression 13 | 333
Nasal congestion 12 | 23
Alcoholic Intoxication, Chronic 11 | 289
Nasal discharge 11 | 25
glioblastoma 11 | 5,792
osteosarcoma 11 | 7,950
Alcohol dependence 10 | 107
Asthma 10 | 385
Autistic Disorder 10 | 364
ependymoma 10 | 4,679
medulloblastoma, large-cell 10 | 6,241
Allergic rhinitis 9 | 95
Hypertension 9 | 396
Substance abuse 9 | 59
Unipolar Depression 9 | 250
diabetes mellitus 9 | 1,728
ovarian cancer 9 | 8,520
Astrocytoma, Pilocytic 8 | 3,081
Bronchitis 8 | 43
General anesthesia 8 | 53
Hypertensive disorder 8 | 57
Obesity 8 | 678
Open-angle glaucoma 8 | 27
Orthostatic hypotension 8 | 9
Pulmonary emphysema 8 | 48
adult high grade glioma 8 | 3,801
oligodendroglioma 8 | 2,850
primitive neuroectodermal tumor 8 | 3,035
Acute exacerbation of asthma 7 | 14
Alzheimer's disease 7 | 658
Asthma management 7 | 19
Bronchiectasis 7 | 64
Cocaine-Related Disorders 7 | 92
Common cold 7 | 69
Epilepsy 7 | 792
Gilles de la Tourette syndrome 7 | 47
Hypotension 7 | 82
Low blood pressure 7 | 9
Seizures 7 | 596
atypical teratoid / rhabdoid tumor 7 | 5,112
malignant mesothelioma 7 | 3,232
obsessive-compulsive disorder 7 | 61
Administration of Local Anesthetic Nerve Block 6 | 14
Allergic Reactions 6 | 7
Allergic conjunctivitis 6 | 22
Amphetamine-Related Disorders 6 | 74
Chronic obstructive lung disease 6 | 6
Dyspnea 6 | 76
Exacerbation of asthma 6 | 11
Gastric ulcer 6 | 33
Hyperprolactinemia 6 | 27
Local anesthesia, by infiltration 6 | 14
Memory Disorders 6 | 40
Migraine Prevention 6 | 23
Ocular hypertension 6 | 42
Peptic Ulcer 6 | 27
Red eye 6 | 7
Sneezing 6 | 12
Vasomotor rhinitis 6 | 13
Wheezing 6 | 7
anaphylaxis 6 | 11
astrocytic glioma 6 | 2,597
group 3 medulloblastoma 6 | 4,104
invasive ductal carcinoma 6 | 2,951
Acromegaly 5 | 51
Alcohol abuse 5 | 50
Amnestic disorder 5 | 35
Cerebral Ischemia 5 | 37
Cerebrovascular disease 5 | 238
Chronic schizophrenia 5 | 16
Cluster headache syndrome 5 | 8
Cough 5 | 25
Dilated pupil 5 | 6
Fever 5 | 138
Gastrointestinal Radiography Adjunct 5 | 11
Hyperactive behavior 5 | 91
Hyperkinesis 5 | 32
Hypertensive Emergencies 5 | 10
Irritable bowel syndrome 5 | 60
Parkinsonism 5 | 18
Paroxysmal hypertension 5 | 6
Peripheral vascular disease 5 | 87
Personality disorder 5 | 25
Pheochromocytoma 5 | 24
Prevention of Hypertension in Pheochromocytoma 5 | 6
Spasticity 5 | 26
Substance Withdrawal Syndrome 5 | 55
Tremor 5 | 113
Urinary Incontinence 5 | 50
lung cancer 5 | 4,740

Tissue

Endocrine System 36 | 18,159
Nervous System 34 | 16,725
Digestive Tract 32 | 17,369
Female tissues 32 | 17,400
Skin and soft tissues 31 | 17,230
Male tissues 30 | 17,142
Respiratory system 30 | 16,393
Liver and Pancreas 29 | 16,750
Blood and immune system 28 | 16,909
Urinary Tract 28 | 16,678
Cardiovascular System 21 | 15,192

Target Family

GPCR 41 | 408

Reactome Pathway

Amine ligand-binding receptors 41 | 41
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.56886 35.9 110
5-hydroxytryptamine receptor 2C HTR2C Tclin GPCR -3.08158 1199.3 336
D(2) dopamine receptor DRD2 Tclin GPCR -3.28700 1882.2 264
Muscarinic acetylcholine receptor M2 CHRM2 Tclin GPCR -2.70017 498.2 391
Muscarinic acetylcholine receptor M4 CHRM4 Tclin GPCR -1.90995 79.8 130
Muscarinic acetylcholine receptor M1 CHRM1 Tclin GPCR -2.16159 140.8 222
Alpha-1B adrenergic receptor ADRA1B Tclin GPCR -2.30594 201.5 364
Histamine H1 receptor HRH1 Tclin GPCR -3.02485 1031.1 393
Beta-3 adrenergic receptor ADRB3 Tclin GPCR -2.73090 568.4 254
Beta-1 adrenergic receptor ADRB1 Tclin GPCR -2.88263 725.8 196