Development Level

Tbio 5 | 11,445

IMPC Phenotype

abnormal heart morphology 1 | 162
decreased mean corpuscular vol... 1 | 79
enlarged heart 1 | 210

Disease

Adrenoleukodystrophy 3 | 29
Atopic dermatitis 3 | 952
Peroxisomal disease 3 | 22
ovarian cancer 3 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
psoriasis 3 | 6,694
Carcinoma 2 | 11,493
Infantile Refsum disease 2 | 23
Refsum disease 2 | 20
Rhizomelic chondrodysplasia punctata 2 | 11
Zellweger syndrome 2 | 37
astrocytic glioma 2 | 2,597
ductal carcinoma in situ 2 | 1,745
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
oligodendroglioma 2 | 2,850
osteosarcoma 2 | 7,950
ulcerative colitis 2 | 1,819
Abnormal skeletal development 1 | 60
Abnormality of epiphysis morphology 1 | 39
Abnormality of metabolism/homeostasis 1 | 134
Abnormality of retinal pigmentation 1 | 111
Anosmia 1 | 22
Astrocytoma, Pilocytic 1 | 3,081
Beriberi 1 | 12
Blepharoptosis 1 | 231
Breast cancer 1 | 3,578
Cardiac Arrhythmia 1 | 103
Cardiac conduction abnormalities 1 | 78
Cardiomegaly 1 | 116
Cardiomyopathies 1 | 110
Cerebrospinal fluid protein increased above normal 1 | 14
Chemical and Drug Induced Liver Injury 1 | 195
Cholestasis 1 | 155
Chondrodysplasia punctata 1 | 41
Conduction disorder of the heart 1 | 79
Congenital pes cavus 1 | 88
Congestive heart failure 1 | 113
Decreased tendon reflex 1 | 122
Developmental regression 1 | 95
Difficulties with night vision 1 | 87
Dry skin 1 | 75
EKG abnormalities 1 | 78
Electrocardiogram abnormal 1 | 81
Electrocardiogram change 1 | 78
Elevated levels of phytanic acid 1 | 15
Fibrosis 1 | 44
Hammer Toe 1 | 23
Heart failure 1 | 162
Hemangiopericytoma 1 | 5
Hemiplegia and hemiparesis 1 | 38
Hirschsprung's disease 1 | 46
Hypesthesia 1 | 7
Ichthyoses 1 | 41
Leber congenital amaurosis 1 | 69
Loss of developmental milestones 1 | 95
Low Vision 1 | 174
Lymphoma 1 | 81
Mental deterioration in childhood 1 | 95
Miosis disorder 1 | 6
Multiple epiphyseal dysplasia 1 | 18
Muscle weakness of limb 1 | 21
Nail dysplasia 1 | 52
Neurodevelopmental regression 1 | 95
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Neuropathy 1 | 261
Night Blindness 1 | 101
Osteochondrodysplasias 1 | 72
Peripheral Neuropathy 1 | 134
Peripheral sensorimotor neuropathy 1 | 16
Psychomotor regression 1 | 95
Psychomotor regression beginning in infancy 1 | 95
Psychomotor regression in infants 1 | 95
Psychomotor regression, progressive 1 | 95
Pyramidal sign 1 | 29
Retinal Degeneration 1 | 106
Retinal Diseases 1 | 55
Retinal pigment epithelial abnormality 1 | 111
Sensorineural Hearing Loss (disorder) 1 | 284
Severe mental retardation (I.Q. 20-34) 1 | 99
Short metacarpal 1 | 43
Skeletal muscle atrophy 1 | 139
Visual Impairment 1 | 174
Xerosis 1 | 75
alpha-methylacyl-CoA racemase deficiency 1 | 9
interstitial cystitis 1 | 2,312
invasive ductal carcinoma 1 | 2,951
lung adenocarcinoma 1 | 2,716
muscle degeneration 1 | 139
nasopharyngeal carcinoma 1 | 1,058
nephrosclerosis 1 | 333
non-small cell lung cancer 1 | 2,890
pediatric high grade glioma 1 | 1,064
pituitary cancer 1 | 1,972
posterior fossa group B ependymoma 1 | 416
spina bifida 1 | 1,074
substance-related disorder 1 | 162
tuberculosis 1 | 2,010

Tissue

Blood and immune system 5 | 16,909
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678
Cardiovascular System 4 | 15,192

Target Family

Enzyme 3 | 4,145
Transporter 2 | 473

Reactome Pathway

Alpha-oxidation of phytanate 5 | 5
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisomal membrane protein PMP34 SLC25A17 Tbio Transporter -2.14978 108.6 79
Very long-chain acyl-CoA synthetase SLC27A2 Tbio Transporter -1.73251 54.7 121
Peroxisomal trans-2-enoyl-CoA reductase PECR Tbio Enzyme -1.66224 43.2 104
2-hydroxyacyl-CoA lyase 1 HACL1 Tbio Enzyme -1.82472 63.8 159
Phytanoyl-CoA dioxygenase, peroxisomal PHYH Tbio Enzyme -2.34936 221.5 300