Development Level

Tbio 606 | 11,651
Tdark 156 | 6,593
Tchem 93 | 1,388
Tclin 37 | 612

Collection

Kinase: IDG Consortium (Target... 5 | 125

IMPC Phenotype

preweaning lethality, complete... 52 | 979
preweaning lethality, incomple... 29 | 499
abnormal behavior 18 | 298
embryonic lethality prior to t... 17 | 278
short tibia 13 | 97
decreased bone mineral content 12 | 151
decreased total body fat amoun... 12 | 207
decreased body weight 11 | 161
increased lean body mass 11 | 172
abnormal bone structure 10 | 187
abnormal embryo size 10 | 220
decreased lean body mass 10 | 135
decreased bone mineral density 9 | 126
decreased vertical activity 9 | 208
embryonic lethality prior to o... 9 | 239
increased total body fat amoun... 9 | 134
male infertility 9 | 123
decreased lymphocyte cell numb... 8 | 83
hypoactivity 8 | 132
increased mean corpuscular vol... 8 | 92
decreased circulating choleste... 7 | 93
decreased hemoglobin content 7 | 68
decreased startle reflex 7 | 75
enlarged heart 7 | 210
increased neutrophil cell numb... 7 | 46
increased or absent threshold ... 7 | 101
abnormal heart morphology 6 | 162
abnormal skin morphology 6 | 50
decreased blood urea nitrogen ... 6 | 51
decreased circulating triglyce... 6 | 79
decreased heart left ventricle... 6 | 28
increased monocyte cell number 6 | 63
abnormal lens morphology 5 | 81
abnormal retina morphology 5 | 71
abnormal seminal vesicle morph... 5 | 114
cataract 5 | 92
decreased circulating amylase ... 5 | 28
decreased circulating creatini... 5 | 39
decreased circulating glucose ... 5 | 126
decreased hematocrit 5 | 46
decreased mean corpuscular vol... 5 | 79
decreased neutrophil cell numb... 5 | 42
decreased prepulse inhibition 5 | 82
embryonic growth retardation 5 | 106
hyperactivity 5 | 148
impaired glucose tolerance 5 | 75
increased blood urea nitrogen ... 5 | 48
increased bone mineral content 5 | 108
increased circulating alkaline... 5 | 122
increased hematocrit 5 | 46
increased mean corpuscular hem... 5 | 96
increased mean platelet volume 5 | 45
prenatal lethality prior to he... 5 | 87
prolonged QT interval 5 | 38
small superior vagus ganglion 5 | 74
abnormal gait 4 | 69
anophthalmia 4 | 33
decreased body length 4 | 101
decreased caudal vertebrae num... 4 | 53
decreased circulating LDL chol... 4 | 38
decreased circulating alanine ... 4 | 47
decreased erythrocyte cell num... 4 | 62
decreased grip strength 4 | 116
enlarged spleen 4 | 41
female infertility 4 | 60
increased circulating choleste... 4 | 66
increased circulating creatini... 4 | 38
increased leukocyte cell numbe... 4 | 47
increased lymphocyte cell numb... 4 | 32
increased spleen weight 4 | 10
prolonged ST segment 4 | 36
abnormal bone mineralization 3 | 38
abnormal sleep behavior 3 | 70
abnormal vibrissa morphology 3 | 25
cardiovascular system phenotyp... 3 | 36
decreased circulating HDL chol... 3 | 68
decreased circulating alkaline... 3 | 46
decreased circulating aspartat... 3 | 34
decreased circulating chloride... 3 | 30
decreased circulating free fat... 3 | 31
decreased circulating insulin ... 3 | 76
decreased circulating iron lev... 3 | 32
decreased circulating total pr... 3 | 49
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular hem... 3 | 31
decreased red blood cell distr... 3 | 41
dilated heart left ventricle 3 | 11
enlarged lymph nodes 3 | 37
hydrometra 3 | 53
increased circulating HDL chol... 3 | 80
increased circulating chloride... 3 | 41
increased circulating free fat... 3 | 20
increased fasted circulating g... 3 | 76
increased grip strength 3 | 41
increased mean corpuscular hem... 3 | 36
increased startle reflex 3 | 112
prenatal lethality 3 | 28
thrombocytopenia 3 | 56
tremors 3 | 39
trunk curl 3 | 16

Disease

Carcinoma 492 | 11,493
ovarian cancer 425 | 8,520
osteosarcoma 395 | 7,950
psoriasis 356 | 6,694
glioblastoma 294 | 5,792
lung cancer 267 | 4,740
medulloblastoma, large-cell 260 | 6,241
Cancer 257 | 2,499
atypical teratoid / rhabdoid tumor 205 | 5,112
adult high grade glioma 192 | 3,801
lung carcinoma 177 | 2,843
ependymoma 174 | 4,679
diabetes mellitus 167 | 1,728
tuberculosis 161 | 2,010
Astrocytoma, Pilocytic 152 | 3,081
invasive ductal carcinoma 149 | 2,951
Breast cancer 148 | 3,578
interstitial cystitis 148 | 2,312
Rheumatoid arthritis 144 | 1,191
non-small cell lung cancer 141 | 2,890
subependymal giant cell astrocytoma 139 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 135 | 3,291
malignant mesothelioma 133 | 3,232
group 3 medulloblastoma 129 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 129 | 2,989
Multiple myeloma 120 | 1,332
cutaneous lupus erythematosus 119 | 1,057
astrocytic glioma 115 | 2,597
oligodendroglioma 115 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 112 | 2,955
lung adenocarcinoma 112 | 2,716
Kidney cancer 110 | 2,613
ulcerative colitis 110 | 1,819
dermatomyositis 107 | 966
primitive neuroectodermal tumor 106 | 3,035
pancreatic cancer 103 | 2,398
juvenile dermatomyositis 102 | 1,187
Hypersensitivity reaction type II disease 92 | 253
primary Sjogren syndrome 92 | 735
Arthritis 90 | 290
group 4 medulloblastoma 89 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 85 | 1,962
Ankylosing spondylitis 83 | 140
Autosomal recessive predisposition 77 | 1,442
Pick disease 77 | 1,894
Behcet's disease 75 | 89
breast carcinoma 75 | 1,638
astrocytoma 72 | 1,146
Human immunodeficiency virus infectious disease 69 | 138
Multiple Sclerosis 69 | 540
cystic fibrosis 67 | 1,696
Juvenile rheumatoid arthritis 66 | 111
Acquired immunodeficiency syndrome 65 | 197
Uveitis 63 | 103
adrenocortical carcinoma 61 | 1,428
pituitary cancer 61 | 1,972
Herpes zoster 58 | 68
Waldenstrons macroglobulinemia 58 | 765
acute quadriplegic myopathy 58 | 1,158
Psoriatic arthritis 57 | 86
active Crohn's disease 57 | 922
Stevens-Johnson syndrome 55 | 92
colon cancer 55 | 1,478
ductal carcinoma in situ 54 | 1,745
Atopic dermatitis 51 | 952
Dermatitis 50 | 157
Kidney disease 50 | 430
Liver Cirrhosis, Experimental 49 | 769
Schizophrenia 48 | 1,160
primary pancreatic ductal adenocarcinoma 48 | 1,109
Anemia 46 | 365
Duchenne muscular dystrophy 45 | 601
esophageal adenocarcinoma 45 | 737
sarcoidosis 45 | 370
spina bifida 45 | 1,074
acute myeloid leukemia 43 | 783
active ulcerative colitis 41 | 764
Intellectual disability 40 | 1,016
Liver disease 40 | 237
gastric carcinoma 39 | 807
non primary Sjogren syndrome sicca 39 | 891
Synovitis 38 | 78
Takayasu's arteritis 38 | 53
Behcet's syndrome 37 | 50
pediatric high grade glioma 37 | 1,064
Asthma 36 | 385
Congenital adrenal hyperplasia 35 | 73
Nephritis 35 | 51
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
drug-induced hepatitis 35 | 44
nasopharyngeal carcinoma 35 | 1,058
Epilepsy 34 | 792
Hepatitis B 34 | 108
Immunologic Deficiency Syndromes 34 | 113
mucosa-associated lymphoid tissue lymphoma 34 | 484
periodontitis 33 | 293
tuberculosis and treatment for 6 months 33 | 409
Leprosy 32 | 73
Parkinson's disease 32 | 392

Tissue

Endocrine System 710 | 18,159
Digestive Tract 702 | 17,369
Blood and immune system 701 | 16,909
Female tissues 699 | 17,400
Skin and soft tissues 699 | 17,230
Respiratory system 697 | 16,393
Urinary Tract 697 | 16,678
Male tissues 696 | 17,142
Liver and Pancreas 695 | 16,750
Nervous System 679 | 16,725
Cardiovascular System 676 | 15,192

Target Family

Non-IDG 633 | 12,091
Enzyme 206 | 4,145
Kinase 39 | 634
Transcription Factor 8 | 1,400
Ion Channel 6 | 344

Reactome Pathway

Adaptive Immune System 892 | 892
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
CMRF35-like molecule 9 CD300LG Tdark Non-IDG -0.92828 10.3 49
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
Butyrophilin-like protein 9 BTNL9 Tdark Non-IDG -0.69979 4.69 67
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Trem-like transcript 4 protein TREML4 Tbio Non-IDG -0.49474 3.87 36
F-actin-capping protein subunit alpha-3 CAPZA3 Tdark Non-IDG -0.56455 3.20 78