Development Level

Tbio 591 | 10,625
Tdark 151 | 7,003
Tchem 150 | 1,890
Tclin 47 | 602

Collection

Eligible Kinase Proteins 8 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 37 | 633
decreased lean body mass 20 | 195
abnormal behavior 16 | 226
decreased bone mineral content 16 | 157
decreased total body fat amoun... 15 | 186
preweaning lethality, incomple... 15 | 260
decreased grip strength 13 | 123
embryonic lethality prior to t... 13 | 187
decreased body weight 11 | 174
decreased bone mineral density 11 | 126
increased or absent threshold ... 11 | 128
decreased body length 10 | 108
abnormal bone structure 8 | 131
abnormal embryo size 8 | 112
short tibia 8 | 82
abnormal retina morphology 7 | 100
decreased circulating choleste... 7 | 85
decreased circulating triglyce... 7 | 83
increased mean corpuscular vol... 7 | 91
decreased heart weight 6 | 44
decreased startle reflex 6 | 48
hypoactivity 6 | 89
male infertility 6 | 62
abnormal lens morphology 5 | 73
abnormal retinal pigmentation 5 | 61
decreased circulating HDL chol... 5 | 77
decreased circulating LDL chol... 5 | 37
embryonic lethality prior to o... 5 | 148
enlarged heart 5 | 111
hyperactivity 5 | 108
increased bone mineral content 5 | 92
increased circulating HDL chol... 5 | 63
increased circulating alkaline... 5 | 119
increased circulating choleste... 5 | 53
increased grip strength 5 | 83
increased mean corpuscular hem... 5 | 93
abnormal sleep behavior 4 | 63
cataract 4 | 26
decreased circulating alanine ... 4 | 53
decreased circulating amylase ... 4 | 24
decreased circulating glucose ... 4 | 121
decreased mean corpuscular vol... 4 | 50
decreased prepulse inhibition 4 | 52
increased lean body mass 4 | 107
increased leukocyte cell numbe... 4 | 37
increased total body fat amoun... 4 | 57
abnormal bone mineralization 3 | 55
abnormal cornea morphology 3 | 24
abnormal eye morphology 3 | 38
abnormal forebrain development 3 | 18
abnormal hindbrain development 3 | 24
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
abnormal seminal vesicle morph... 3 | 47
abnormal spleen morphology 3 | 36
abnormal testis morphology 3 | 30
absent startle reflex 3 | 15
decreased blood urea nitrogen ... 3 | 31
decreased circulating alkaline... 3 | 41
decreased circulating aspartat... 3 | 27
decreased circulating bilirubi... 3 | 14
decreased circulating chloride... 3 | 32
decreased circulating free fat... 3 | 39
decreased circulating fructosa... 3 | 31
decreased circulating insulin ... 3 | 75
decreased eosinophil cell numb... 3 | 41
decreased erythrocyte cell num... 3 | 43
decreased hemoglobin content 3 | 53
decreased kidney weight 3 | 7
decreased lumbar vertebrae num... 3 | 62
decreased rib number 3 | 59
decreased threshold for audito... 3 | 32
enlarged spleen 3 | 26
increased blood urea nitrogen ... 3 | 44
increased circulating LDL chol... 3 | 15
increased circulating free fat... 3 | 17
increased fasted circulating g... 3 | 68
increased hematocrit 3 | 36
increased startle reflex 3 | 38
small testis 3 | 37
tremors 3 | 34
trunk curl 3 | 15
abnormal coat appearance 2 | 25
abnormal epididymis morphology 2 | 31
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
cardiovascular system phenotyp... 2 | 35
decreased T cell number 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating iron lev... 2 | 25
decreased circulating serum al... 2 | 79
decreased total retina thickne... 2 | 20
decreased vertical activity 2 | 22
impaired glucose tolerance 2 | 52
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased heart weight 2 | 37
increased respiratory quotient 2 | 12
thrombocytopenia 2 | 46
thrombocytosis 2 | 23

Disease

ovarian cancer 451 | 8,484
osteosarcoma 431 | 7,933
psoriasis 388 | 6,685
glioblastoma 312 | 5,572
medulloblastoma, large-cell 295 | 6,234
Cancer 291 | 2,346
lung cancer 285 | 4,466
atypical teratoid / rhabdoid tumor 208 | 4,369
lung carcinoma 189 | 2,844
diabetes mellitus 184 | 1,663
invasive ductal carcinoma 170 | 2,950
pilocytic astrocytoma 166 | 3,086
interstitial cystitis 162 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 156 | 3,289
Breast cancer 155 | 3,094
non-small cell lung cancer 154 | 2,798
subependymal giant cell astrocytoma 153 | 2,287
malignant mesothelioma 149 | 3,162
ulcerative colitis 149 | 2,087
intraductal papillary-mucinous carcinoma (IPMC) 143 | 2,988
Rheumatoid Arthritis 139 | 1,160
pediatric high grade glioma 134 | 2,712
oligodendroglioma 131 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 129 | 2,956
lung adenocarcinoma 129 | 2,713
cutaneous lupus erythematosus 128 | 1,056
tuberculosis 127 | 1,557
Multiple myeloma 120 | 1,327
pancreatic cancer 117 | 2,300
adult high grade glioma 116 | 2,148
primitive neuroectodermal tumor 114 | 3,031
ependymoma 113 | 2,514
juvenile dermatomyositis 107 | 1,189
group 4 medulloblastoma 105 | 1,875
primary Sjogren syndrome 103 | 789
Carcinoma 102 | 2,147
astrocytic glioma 101 | 2,241
astrocytoma 98 | 1,493
Hypersensitivity reaction type II disease 88 | 235
breast carcinoma 87 | 1,614
Pick disease 86 | 1,893
Ankylosing spondylitis 84 | 138
Arthritis 84 | 248
group 3 medulloblastoma 81 | 2,254
posterior fossa group A ependymoma 80 | 1,511
pancreatic ductal adenocarcinoma liver metastasis 79 | 1,795
pituitary cancer 79 | 1,972
cystic fibrosis 76 | 1,665
dermatomyositis 76 | 933
Multiple Sclerosis 72 | 498
adrenocortical carcinoma 72 | 1,427
medulloblastoma 70 | 1,524
Acquired immunodeficiency syndrome 69 | 164
ductal carcinoma in situ 69 | 1,745
colon cancer 66 | 1,475
primary pancreatic ductal adenocarcinoma 66 | 1,271
Juvenile rheumatoid arthritis 65 | 104
acute quadriplegic myopathy 64 | 1,157
Uveitis 61 | 103
Behcet's disease 60 | 74
active Crohn's disease 60 | 918
Kidney disease 58 | 396
Psoriatic arthritis 57 | 83
Waldenstrons macroglobulinemia 56 | 765
IGA Glomerulonephritis 54 | 454
spina bifida 54 | 1,064
tuberculosis and treatment for 6 months 52 | 686
Atopic dermatitis 51 | 944
esophageal adenocarcinoma 51 | 737
Duchenne muscular dystrophy 46 | 602
acute myeloid leukemia 46 | 780
posterior fossa group B ependymoma 46 | 1,530
sonic hedgehog group medulloblastoma 46 | 1,482
gastric carcinoma 44 | 832
Asthma 43 | 349
Stevens-Johnson syndrome 42 | 78
Liver disease 41 | 219
nasopharyngeal carcinoma 41 | 1,056
Anemia 40 | 252
Prostatic Neoplasms 39 | 471
mucosa-associated lymphoid tissue lymphoma 39 | 480
Parkinson's disease 38 | 364
Takayasu's arteritis 38 | 52
sarcoidosis 38 | 358
Alzheimer's disease 37 | 644
Mammary Neoplasms 37 | 410
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
pancreatic carcinoma 35 | 567
Leprosy 34 | 77
non primary Sjogren syndrome sicca 34 | 840
Down syndrome 32 | 548
Endometriosis 32 | 535
Obesity 32 | 616
atypical teratoid/rhabdoid tumor 32 | 1,095
head and neck cancer and chronic obstructive pulmonary disease 32 | 237
Intellectual disability 31 | 573
Vascular disease 31 | 281
periodontitis 31 | 269
progressive supranuclear palsy 31 | 674

Tissue

Blood and immune system 839 | 17,995
Female tissues 838 | 18,647
Digestive Tract 836 | 18,473
Nervous System 835 | 18,561
Urinary Tract 834 | 18,444
Liver and Pancreas 833 | 18,136
Endocrine System 831 | 18,512
Cardiovascular System 829 | 17,958
Male tissues 825 | 17,969
Respiratory system 822 | 17,484
Skin and soft tissues 820 | 18,115

Target Family

Non-IDG 646 | 11,971
Enzyme 213 | 4,146
Kinase 63 | 634
Transcription Factor 10 | 1,400
Ion Channel 6 | 341
Nuclear Receptor 1 | 48

Reactome Pathway

Adaptive Immune System 939 | 939
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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